Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2

Osteoarthritis (OA), a degenerative disorder, is considered to be one of the most common forms of arthritis. Limonin (Lim) is extracted from lemons and other citrus fruits. Limonin has been reported to have anti-inflammatory effects, while inflammation is a major cause of OA; thus, we propose that l...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.7292512-7292512
Hauptverfasser:	Jin, Jie, Lv, Xinhuang, Wang, Ben, Ren, Chenghao, Jiang, Jingtao, Chen, Hongyu, Chen, Ximiao, Gu, Mingbao, Pan, Zongyou, Tian, Naifeng, Wu, Aimin, Sun, Liaojun, Gao, Weiyang, Wang, Xiangyang, Zhang, Xiaolei, Wu, Yaosen, Zhou, Yifei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - etiology Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Cartilage Chondrocytes - drug effects Chondrocytes - metabolism Chondrocytes - pathology Collagen Gene Expression Regulation Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism Inflammation Inflammation - drug therapy Inflammation - etiology Inflammation - metabolism Inflammation - pathology Interleukin-1beta - toxicity Knee Limonins - pharmacology Male Membranes Menisci, Tibial - surgery Mice Mice, Inbred C57BL NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NF-kappa B - genetics NF-kappa B - metabolism Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - etiology Osteoarthritis - metabolism Osteoarthritis - pathology Pathogenesis Proteins
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