Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence

In an aging population, intense interest has shifted toward prolonging health span. Mounting evidence suggests that cellular reactive species are propagators of cell damage, inflammation, and cellular senescence. Thus, such species have emerged as putative provocateurs and targets for senolysis, and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-10, Vol.118 (42), p.1-11
Hauptverfasser:	Li, Yao, Kračun, Damir, Dustin, Christopher M., Massry, Mohamed El, Yuan, Shuai, Goossen, Christian J., DeVallance, Evan R., Sahoo, Sanghamitra, Hilaire, Cynthia St, Gurkar, Aditi U., Finkel, Toren, Straub, Adam C., Cifuentes-Pagano, Eugenia, Pagano, Patrick J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - physiology Angiogenesis Animals Biological Sciences Blood flow Damage Diabetes mellitus DNA Damage Down-regulation Endothelial cells Gene Knockdown Techniques Humans Hyperglycemia Hyperglycemia - metabolism Inflammation Interleukin 6 Interleukin-6 - metabolism Mice NAD(P)H oxidase NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - genetics NADPH Oxidases - metabolism Neovascularization, Physiologic - physiology Operant conditioning Peroxisome proliferator-activated receptors Phenotypes Senescence Senescence-Associated Secretory Phenotype Signaling System effectiveness Transcription Vasodilation
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