Characterization of a pulsatile rotary total artificial heart
This article describes the properties and performance of a rotary total artificial heart (TAH) that produces inherently pulsatile flow. The hydraulic performance of the TAH was characterized using a mock circulatory loop to simulate four physiologically relevant conditions: baseline flow, increased...
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| Veröffentlicht in: | Artificial organs 2021-02, Vol.45 (2), p.135-142 |
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| container_end_page | 142 |
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| container_title | Artificial organs |
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| creator | Jurney, Patrick L. Glynn, Jeremy J. Dykan, Igor V. Hagen, Matthew W. Kaul, Sanjiv Wampler, Richard K. Hinds, Monica T. Giraud, George D. |
| description | This article describes the properties and performance of a rotary total artificial heart (TAH) that produces inherently pulsatile flow. The hydraulic performance of the TAH was characterized using a mock circulatory loop to simulate four physiologically relevant conditions: baseline flow, increased flow, systemic hypertension, and pulmonary hypertension. The pump has a variable shuttle rate (beats per minute), percentage dwell time, and angular velocity on either side (revolutions per minute), which allows for full control of the flow rate and pulsatility over a range of healthy and pathologic pressures and flow rates. The end‐to‐end length and displacement volume of the TAH are 9.8 cm and 130 mL, respectively, allowing it to fit in smaller chest cavities including those of smaller adults and juvenile humans. |
| doi_str_mv | 10.1111/aor.13810 |
| format | Article |
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The hydraulic performance of the TAH was characterized using a mock circulatory loop to simulate four physiologically relevant conditions: baseline flow, increased flow, systemic hypertension, and pulmonary hypertension. The pump has a variable shuttle rate (beats per minute), percentage dwell time, and angular velocity on either side (revolutions per minute), which allows for full control of the flow rate and pulsatility over a range of healthy and pathologic pressures and flow rates. The end‐to‐end length and displacement volume of the TAH are 9.8 cm and 130 mL, respectively, allowing it to fit in smaller chest cavities including those of smaller adults and juvenile humans.</description><subject>Angular velocity</subject><subject>Artificial organs</subject><subject>cardiovascular devices</subject><subject>Dwell time</subject><subject>Flow velocity</subject><subject>heart failure</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - surgery</subject><subject>Heart Ventricles - physiopathology</subject><subject>Heart, Artificial</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Models, Cardiovascular</subject><subject>Prosthesis Design</subject><subject>Pulsatile Flow - physiology</subject><subject>total artificial heart</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLAzEUhYMoWh8L_4AMuNHFtHnPzEKhFF9QKIiCu5BJMzZlOqnJjKK_3qutooLZ3FzycTg5B6FDgvsEzkD70CcsJ3gD9YigIiWi4Juoh4nEqZD8YQftxjjHGGccy220w2gusrwQPXQ2mumgTWuDe9Ot803iq0Qny66OsNY2Cb7V4TVpYdSJDq2rnHFwnVlY9tFWpetoD9ZzD91fXtyNrtPx5OpmNBynhnOG04LlBZe5KEWFsebSliUvJNGYME2onWa0YmUmKkMKIaaETSmzWWkkLQtuKirZHjpf6S67cmGnxjZt0LVaBrcAc8prp36_NG6mHv2zyiEILDMQOFkLBP_U2diqhYvG1rVurO-iopzlsqAUc0CP_6Bz34UGvgcUIBlkR4A6XVEm-BiDrb7NEKw-SlFQivosBdijn-6_ya8WABisgBdI_PV_JTWc3K4k3wFIm5YA</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Jurney, Patrick L.</creator><creator>Glynn, Jeremy J.</creator><creator>Dykan, Igor V.</creator><creator>Hagen, Matthew W.</creator><creator>Kaul, Sanjiv</creator><creator>Wampler, Richard K.</creator><creator>Hinds, Monica T.</creator><creator>Giraud, George D.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4099-2927</orcidid></search><sort><creationdate>202102</creationdate><title>Characterization of a pulsatile rotary total artificial heart</title><author>Jurney, Patrick L. ; Glynn, Jeremy J. ; Dykan, Igor V. ; Hagen, Matthew W. ; Kaul, Sanjiv ; Wampler, Richard K. ; Hinds, Monica T. ; Giraud, George D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4430-93894685b5f00a46ebb4961a013a12ed72f3b75fc1955d13d23e7bc62b94cf263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Angular velocity</topic><topic>Artificial organs</topic><topic>cardiovascular devices</topic><topic>Dwell time</topic><topic>Flow velocity</topic><topic>heart failure</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - surgery</topic><topic>Heart Ventricles - physiopathology</topic><topic>Heart, Artificial</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Models, Cardiovascular</topic><topic>Prosthesis Design</topic><topic>Pulsatile Flow - physiology</topic><topic>total artificial heart</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jurney, Patrick L.</creatorcontrib><creatorcontrib>Glynn, Jeremy J.</creatorcontrib><creatorcontrib>Dykan, Igor V.</creatorcontrib><creatorcontrib>Hagen, Matthew W.</creatorcontrib><creatorcontrib>Kaul, Sanjiv</creatorcontrib><creatorcontrib>Wampler, Richard K.</creatorcontrib><creatorcontrib>Hinds, Monica T.</creatorcontrib><creatorcontrib>Giraud, George D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jurney, Patrick L.</au><au>Glynn, Jeremy J.</au><au>Dykan, Igor V.</au><au>Hagen, Matthew W.</au><au>Kaul, Sanjiv</au><au>Wampler, Richard K.</au><au>Hinds, Monica T.</au><au>Giraud, George D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of a pulsatile rotary total artificial heart</atitle><jtitle>Artificial organs</jtitle><addtitle>Artif Organs</addtitle><date>2021-02</date><risdate>2021</risdate><volume>45</volume><issue>2</issue><spage>135</spage><epage>142</epage><pages>135-142</pages><issn>0160-564X</issn><eissn>1525-1594</eissn><abstract>This article describes the properties and performance of a rotary total artificial heart (TAH) that produces inherently pulsatile flow. 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| source | MEDLINE; Wiley Online Library |
| subjects | Angular velocity Artificial organs cardiovascular devices Dwell time Flow velocity heart failure Heart Failure - physiopathology Heart Failure - surgery Heart Ventricles - physiopathology Heart, Artificial Humans Hypertension Hypertension - physiopathology Hypertension, Pulmonary - physiopathology Models, Cardiovascular Prosthesis Design Pulsatile Flow - physiology total artificial heart |
| title | Characterization of a pulsatile rotary total artificial heart |
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