Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta‐analysis
This paper is a proposal for an update on the characterization of cognitive impairments associated with sporadic cerebral small vessel disease (SVD). We pose a series of questions about the nature of SVD‐related cognitive impairments and provide answers based on a comprehensive review and meta‐analy...
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| Veröffentlicht in: | Alzheimer's & dementia 2021-04, Vol.17 (4), p.665-685 |
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| creator | Hamilton, Olivia K. L. Backhouse, Ellen V. Janssen, Esther Jochems, Angela C. C. Maher, Caragh Ritakari, Tuula E. Stevenson, Anna J. Xia, Lihua Deary, Ian J. Wardlaw, Joanna M. |
| description | This paper is a proposal for an update on the characterization of cognitive impairments associated with sporadic cerebral small vessel disease (SVD). We pose a series of questions about the nature of SVD‐related cognitive impairments and provide answers based on a comprehensive review and meta‐analysis of published data from 69 studies. Although SVD is thought primarily to affect executive function and processing speed, we hypothesize that SVD affects all major domains of cognitive ability. We also identify low levels of education as a potentially modifiable risk factor for SVD‐related cognitive impairment. Therefore, we propose the use of comprehensive cognitive assessments and the measurement of educational level both in clinics and research settings, and suggest several recommendations for future research. |
| doi_str_mv | 10.1002/alz.12221 |
| format | Article |
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L. ; Backhouse, Ellen V. ; Janssen, Esther ; Jochems, Angela C. C. ; Maher, Caragh ; Ritakari, Tuula E. ; Stevenson, Anna J. ; Xia, Lihua ; Deary, Ian J. ; Wardlaw, Joanna M.</creator><creatorcontrib>Hamilton, Olivia K. L. ; Backhouse, Ellen V. ; Janssen, Esther ; Jochems, Angela C. C. ; Maher, Caragh ; Ritakari, Tuula E. ; Stevenson, Anna J. ; Xia, Lihua ; Deary, Ian J. ; Wardlaw, Joanna M.</creatorcontrib><description>This paper is a proposal for an update on the characterization of cognitive impairments associated with sporadic cerebral small vessel disease (SVD). We pose a series of questions about the nature of SVD‐related cognitive impairments and provide answers based on a comprehensive review and meta‐analysis of published data from 69 studies. Although SVD is thought primarily to affect executive function and processing speed, we hypothesize that SVD affects all major domains of cognitive ability. We also identify low levels of education as a potentially modifiable risk factor for SVD‐related cognitive impairment. 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Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4151-56f6eb1206d68682839f1ae507c94e40d5acc0c8a1b55465b539c080d74e5c673</citedby><cites>FETCH-LOGICAL-c4151-56f6eb1206d68682839f1ae507c94e40d5acc0c8a1b55465b539c080d74e5c673</cites><orcidid>0000-0001-7392-3066 ; 0000-0002-5874-0058 ; 0000-0002-2655-5499 ; 0000-0002-9812-6642 ; 0000-0001-5083-9945 ; 0000-0002-1733-263X ; 0000-0002-2409-2929 ; 0000-0002-0435-3562</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falz.12221$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falz.12221$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33185327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamilton, Olivia K. L.</creatorcontrib><creatorcontrib>Backhouse, Ellen V.</creatorcontrib><creatorcontrib>Janssen, Esther</creatorcontrib><creatorcontrib>Jochems, Angela C. C.</creatorcontrib><creatorcontrib>Maher, Caragh</creatorcontrib><creatorcontrib>Ritakari, Tuula E.</creatorcontrib><creatorcontrib>Stevenson, Anna J.</creatorcontrib><creatorcontrib>Xia, Lihua</creatorcontrib><creatorcontrib>Deary, Ian J.</creatorcontrib><creatorcontrib>Wardlaw, Joanna M.</creatorcontrib><title>Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta‐analysis</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>This paper is a proposal for an update on the characterization of cognitive impairments associated with sporadic cerebral small vessel disease (SVD). 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Therefore, we propose the use of comprehensive cognitive assessments and the measurement of educational level both in clinics and research settings, and suggest several recommendations for future research.</description><subject>Aging - physiology</subject><subject>cerebral small vessel disease</subject><subject>Cerebral Small Vessel Diseases - complications</subject><subject>Cognition</subject><subject>cognitive ability</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Educational Status</subject><subject>Executive Function</subject><subject>Humans</subject><subject>lacunar stroke</subject><subject>Magnetic Resonance Imaging</subject><subject>meta‐analysis</subject><subject>Neuropsychological Tests</subject><subject>Stroke - complications</subject><subject>systematic review</subject><subject>vascular cognitive impairment</subject><subject>vascular dementia</subject><issn>1552-5260</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kcFuEzEQhi1ERUvgwAtUPsIhre21vd4ekKKIQqVIXMqFizXrnQQj727q2aQKJx6hz9gnYSFtVA49eSR_-uYf_Yy9k-JMCqHOIf06k0op-YKdSGPU1KiyenmYrThmr4l-CqGFk-YVOy4K6UyhyhO2mverLg5xizy2a4i5xW7gseO07jM0MfCAGesMiVMLKfEtEmHiTSQEwgs-47SjAVsYRjbjNuIth67hLQ5w__sOOkg7ivSGHS0hEb59eCfs2-Wn6_mX6eLr56v5bDENWho5NXZpsZZK2MY665QrqqUENKIMlUYtGgMhiOBA1sZoa2pTVEE40ZQaTbBlMWEf9971pm6xCeM1Y3a_zrGFvPM9RP__Txd_-FW_9c5UhdZmFLx_EOT-ZoM0-DZSwJSgw35DXmkrSuuKMdqEfdijIfdEGZeHNVL4v8X4sRj_r5iRPX2a60A-NjEC53vgNibcPW_ys8X3vfIPiCyaiw</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Hamilton, Olivia K. 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L. ; Backhouse, Ellen V. ; Janssen, Esther ; Jochems, Angela C. 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We pose a series of questions about the nature of SVD‐related cognitive impairments and provide answers based on a comprehensive review and meta‐analysis of published data from 69 studies. Although SVD is thought primarily to affect executive function and processing speed, we hypothesize that SVD affects all major domains of cognitive ability. We also identify low levels of education as a potentially modifiable risk factor for SVD‐related cognitive impairment. 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| ispartof | Alzheimer's & dementia, 2021-04, Vol.17 (4), p.665-685 |
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| subjects | Aging - physiology cerebral small vessel disease Cerebral Small Vessel Diseases - complications Cognition cognitive ability Cognitive Dysfunction - etiology Educational Status Executive Function Humans lacunar stroke Magnetic Resonance Imaging meta‐analysis Neuropsychological Tests Stroke - complications systematic review vascular cognitive impairment vascular dementia |
| title | Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta‐analysis |
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