Buyang Huanwu Decoction protects against STZ-induced diabetic nephropathy by inhibiting TGF-β/Smad3 signaling-mediated renal fibrosis and inflammation

Background Buyang Huanwu Decoction (BHD) is a classical Chinese Medicine formula empirically used for diabetic nephropathy (DN). However, its therapeutic efficacies and the underlying mechanisms remain obscure. In our study, we aim to evaluate the renoprotective effect of BHD on a streptozotocin (ST...

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Veröffentlicht in:	Chinese medicine 2021-11, Vol.16 (1), p.1-118, Article 118
Hauptverfasser:	Wu, Weifeng, Wang, Yifan, Li, Haidi, Chen, Haiyong, Shen, Jiangang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antibodies Buyang Huanwu Decoction Calycosin-7-Glucoside Chinese medicine Chromatography Citric acid Creatinine Diabetes Diabetes mellitus Diabetic nephropathy Extracellular matrix Fibrosis Glucose High-performance liquid chromatography Inflammation Ingredients Ischemia Laboratory animals Mesangial cells Molecular modelling Nephropathy NF-κB protein Quality control Renal function Smad3 protein Smad7 protein Streptozocin TGF-β1 Transforming growth factor-b1 Urine
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