Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors

The PI3K/AKT/mTOR and PIM kinase pathways contribute to the development of several hallmarks of cancer. Cotargeting of these pathways has exhibited promising synergistic therapeutic effects in liquid and solid tumor types. To identify molecules with combined activities, we cross-screened our collect...

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Veröffentlicht in:	ACS medicinal chemistry letters 2021-11, Vol.12 (11), p.1794-1801
Hauptverfasser:	Martínez-González, Sonia, Alvarez, Rosa M, Martín, José I, García, Ana Belén, Riesco-Fagundo, Concepción, Varela, Carmen, Rodríguez Hergueta, Antonio, González Cantalapiedra, Esther, Albarrán, M. I, Gómez-Casero, Elena, Cebriá, Antonio, Aguirre, Enara, Ajenjo, Nuria, Cebrián, David, Di Geronimo, Bruno, Cunningham, Darren, O’Neill, Michael, Dave, Harish P. G, Blanco-Aparicio, Carmen, Pastor, Joaquín
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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