Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma: A Systematic Review and Retrospective Cohort Study
Background Our aim is to show whether the sentinel node procedure (SNP) is recommendable for pediatric patients with extremity rhabdomyosarcoma (RMS). Lymph node metastases are an important prognostic factor in pediatric patients with extremity RMS. Accurate nodal staging is necessary to treat the p...
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| Veröffentlicht in: | Annals of surgical oncology 2021-12, Vol.28 (13), p.9048-9059 |
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| container_title | Annals of surgical oncology |
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| creator | Jeremiasse, Bernadette van der Steeg, Alida F. W. Fiocco, Marta Hobbelink, Monique G. G. Merks, Johannes H. M. Godzinski, Jan Shulkin, Barry L. Wijnen, Marc H. W. A. Terwisscha van Scheltinga, Cecilia E. J. |
| description | Background
Our aim is to show whether the sentinel node procedure (SNP) is recommendable for pediatric patients with extremity rhabdomyosarcoma (RMS). Lymph node metastases are an important prognostic factor in pediatric patients with extremity RMS. Accurate nodal staging is necessary to treat the patient accordingly. An alternative to the current recommended lymph node sampling is the sentinel node procedure (SNP).
Methods
A systematic review was performed summarizing all published cases of SNP in addition to 13 cases from our hospital and 8 cases from two other hospitals that have not been published before.
Results
For all patients (
n
= 55), at least one SLN was identified, but the SNP technique used was not uniform. The SNP changed the nodal classification of eight patients (17.0%) and had a false-negative rate of 10.5%.
Conclusions
The SNP is recommendable for pediatric patients with extremity RMS. It can change lymph node status and can be used to sample patients in a more targeted way than nodal sampling alone. Therefore, we recommend use of the SNP in addition to clinical and radiological nodal assessment for pediatric patients with extremity RMS. |
| doi_str_mv | 10.1245/s10434-021-10035-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8591006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2597364087</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-98cc8d23f992668e21bb6c691c0c90f838ed5e7820d31be08ddb4452d45e5be73</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhSMEog_4AyyQJTZsAnb8iM0CqRq1gFRB1QG2lmPfdFwl8WA7A9nx03GZUh4LVr7y_Xx8zz1V9YTgF6Rh_GUimFFW44bUBGPKa3WvOiS8XDEhyf1SYyFr1Qh-UB2ldI0xaSnmD6sDyjBvuWgPq--fzTADCj3KG0BrmLKfYEDvgwN0EYMFN0dAfkIX4LzJ0Vt0-i1HGH1e0OXGdC6MS0gm2jCaV-gErZeUYTS5gJew8_AVmcmVMseQtmCz3wFahU2IGa3z7JZH1YPeDAke357H1aez04-rt_X5hzfvVifntWUty7WS1krX0F4VP0JCQ7pOWKGIxVbhXlIJjkMrG-wo6QBL5zrGeOMYB95BS4-r13vd7dyN4GxxGs2gt9GPJi46GK__7kx-o6_CTkuuynZFEXh-KxDDlxlS1qNPFobBTBDmpBtOOcFSKFnQZ_-g12GOU7FXKNVSwbC8majZU7asJkXo74YhWN8ErPcB6xKw_hmwVuXR0z9t3D35lWgB6B5IpTVdQfz9939kfwAxj7NJ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2597364087</pqid></control><display><type>article</type><title>Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma: A Systematic Review and Retrospective Cohort Study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Jeremiasse, Bernadette ; van der Steeg, Alida F. W. ; Fiocco, Marta ; Hobbelink, Monique G. G. ; Merks, Johannes H. M. ; Godzinski, Jan ; Shulkin, Barry L. ; Wijnen, Marc H. W. A. ; Terwisscha van Scheltinga, Cecilia E. J.</creator><creatorcontrib>Jeremiasse, Bernadette ; van der Steeg, Alida F. W. ; Fiocco, Marta ; Hobbelink, Monique G. G. ; Merks, Johannes H. M. ; Godzinski, Jan ; Shulkin, Barry L. ; Wijnen, Marc H. W. A. ; Terwisscha van Scheltinga, Cecilia E. J.</creatorcontrib><description>Background
Our aim is to show whether the sentinel node procedure (SNP) is recommendable for pediatric patients with extremity rhabdomyosarcoma (RMS). Lymph node metastases are an important prognostic factor in pediatric patients with extremity RMS. Accurate nodal staging is necessary to treat the patient accordingly. An alternative to the current recommended lymph node sampling is the sentinel node procedure (SNP).
Methods
A systematic review was performed summarizing all published cases of SNP in addition to 13 cases from our hospital and 8 cases from two other hospitals that have not been published before.
Results
For all patients (
n
= 55), at least one SLN was identified, but the SNP technique used was not uniform. The SNP changed the nodal classification of eight patients (17.0%) and had a false-negative rate of 10.5%.
Conclusions
The SNP is recommendable for pediatric patients with extremity RMS. It can change lymph node status and can be used to sample patients in a more targeted way than nodal sampling alone. Therefore, we recommend use of the SNP in addition to clinical and radiological nodal assessment for pediatric patients with extremity RMS.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-021-10035-9</identifier><identifier>PMID: 34057567</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Child ; Cohort analysis ; Extremities - pathology ; Extremities - surgery ; Humans ; Lymph Node Excision ; Lymph nodes ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic system ; Medicine ; Medicine & Public Health ; Metastases ; Neoplasm Staging ; Oncology ; Patients ; Pediatric Oncology ; Pediatrics ; Retrospective Studies ; Rhabdomyosarcoma ; Rhabdomyosarcoma - pathology ; Rhabdomyosarcoma - surgery ; Sampling ; Sentinel Lymph Node - pathology ; Sentinel Lymph Node - surgery ; Sentinel Lymph Node Biopsy ; Surgery ; Surgical Oncology ; Systematic review</subject><ispartof>Annals of surgical oncology, 2021-12, Vol.28 (13), p.9048-9059</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-98cc8d23f992668e21bb6c691c0c90f838ed5e7820d31be08ddb4452d45e5be73</citedby><cites>FETCH-LOGICAL-c474t-98cc8d23f992668e21bb6c691c0c90f838ed5e7820d31be08ddb4452d45e5be73</cites><orcidid>0000-0001-7993-0208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-021-10035-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-021-10035-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34057567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeremiasse, Bernadette</creatorcontrib><creatorcontrib>van der Steeg, Alida F. W.</creatorcontrib><creatorcontrib>Fiocco, Marta</creatorcontrib><creatorcontrib>Hobbelink, Monique G. G.</creatorcontrib><creatorcontrib>Merks, Johannes H. M.</creatorcontrib><creatorcontrib>Godzinski, Jan</creatorcontrib><creatorcontrib>Shulkin, Barry L.</creatorcontrib><creatorcontrib>Wijnen, Marc H. W. A.</creatorcontrib><creatorcontrib>Terwisscha van Scheltinga, Cecilia E. J.</creatorcontrib><title>Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma: A Systematic Review and Retrospective Cohort Study</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Our aim is to show whether the sentinel node procedure (SNP) is recommendable for pediatric patients with extremity rhabdomyosarcoma (RMS). Lymph node metastases are an important prognostic factor in pediatric patients with extremity RMS. Accurate nodal staging is necessary to treat the patient accordingly. An alternative to the current recommended lymph node sampling is the sentinel node procedure (SNP).
Methods
A systematic review was performed summarizing all published cases of SNP in addition to 13 cases from our hospital and 8 cases from two other hospitals that have not been published before.
Results
For all patients (
n
= 55), at least one SLN was identified, but the SNP technique used was not uniform. The SNP changed the nodal classification of eight patients (17.0%) and had a false-negative rate of 10.5%.
Conclusions
The SNP is recommendable for pediatric patients with extremity RMS. It can change lymph node status and can be used to sample patients in a more targeted way than nodal sampling alone. Therefore, we recommend use of the SNP in addition to clinical and radiological nodal assessment for pediatric patients with extremity RMS.</description><subject>Child</subject><subject>Cohort analysis</subject><subject>Extremities - pathology</subject><subject>Extremities - surgery</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic system</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pediatric Oncology</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Rhabdomyosarcoma</subject><subject>Rhabdomyosarcoma - pathology</subject><subject>Rhabdomyosarcoma - surgery</subject><subject>Sampling</subject><subject>Sentinel Lymph Node - pathology</subject><subject>Sentinel Lymph Node - surgery</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Systematic review</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtv1DAUhSMEog_4AyyQJTZsAnb8iM0CqRq1gFRB1QG2lmPfdFwl8WA7A9nx03GZUh4LVr7y_Xx8zz1V9YTgF6Rh_GUimFFW44bUBGPKa3WvOiS8XDEhyf1SYyFr1Qh-UB2ldI0xaSnmD6sDyjBvuWgPq--fzTADCj3KG0BrmLKfYEDvgwN0EYMFN0dAfkIX4LzJ0Vt0-i1HGH1e0OXGdC6MS0gm2jCaV-gErZeUYTS5gJew8_AVmcmVMseQtmCz3wFahU2IGa3z7JZH1YPeDAke357H1aez04-rt_X5hzfvVifntWUty7WS1krX0F4VP0JCQ7pOWKGIxVbhXlIJjkMrG-wo6QBL5zrGeOMYB95BS4-r13vd7dyN4GxxGs2gt9GPJi46GK__7kx-o6_CTkuuynZFEXh-KxDDlxlS1qNPFobBTBDmpBtOOcFSKFnQZ_-g12GOU7FXKNVSwbC8majZU7asJkXo74YhWN8ErPcB6xKw_hmwVuXR0z9t3D35lWgB6B5IpTVdQfz9939kfwAxj7NJ</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Jeremiasse, Bernadette</creator><creator>van der Steeg, Alida F. W.</creator><creator>Fiocco, Marta</creator><creator>Hobbelink, Monique G. G.</creator><creator>Merks, Johannes H. M.</creator><creator>Godzinski, Jan</creator><creator>Shulkin, Barry L.</creator><creator>Wijnen, Marc H. W. A.</creator><creator>Terwisscha van Scheltinga, Cecilia E. J.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7993-0208</orcidid></search><sort><creationdate>20211201</creationdate><title>Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma: A Systematic Review and Retrospective Cohort Study</title><author>Jeremiasse, Bernadette ; van der Steeg, Alida F. W. ; Fiocco, Marta ; Hobbelink, Monique G. G. ; Merks, Johannes H. M. ; Godzinski, Jan ; Shulkin, Barry L. ; Wijnen, Marc H. W. A. ; Terwisscha van Scheltinga, Cecilia E. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-98cc8d23f992668e21bb6c691c0c90f838ed5e7820d31be08ddb4452d45e5be73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Child</topic><topic>Cohort analysis</topic><topic>Extremities - pathology</topic><topic>Extremities - surgery</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic system</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Patients</topic><topic>Pediatric Oncology</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Rhabdomyosarcoma</topic><topic>Rhabdomyosarcoma - pathology</topic><topic>Rhabdomyosarcoma - surgery</topic><topic>Sampling</topic><topic>Sentinel Lymph Node - pathology</topic><topic>Sentinel Lymph Node - surgery</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeremiasse, Bernadette</creatorcontrib><creatorcontrib>van der Steeg, Alida F. 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J.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeremiasse, Bernadette</au><au>van der Steeg, Alida F. W.</au><au>Fiocco, Marta</au><au>Hobbelink, Monique G. G.</au><au>Merks, Johannes H. M.</au><au>Godzinski, Jan</au><au>Shulkin, Barry L.</au><au>Wijnen, Marc H. W. A.</au><au>Terwisscha van Scheltinga, Cecilia E. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma: A Systematic Review and Retrospective Cohort Study</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>28</volume><issue>13</issue><spage>9048</spage><epage>9059</epage><pages>9048-9059</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Our aim is to show whether the sentinel node procedure (SNP) is recommendable for pediatric patients with extremity rhabdomyosarcoma (RMS). Lymph node metastases are an important prognostic factor in pediatric patients with extremity RMS. Accurate nodal staging is necessary to treat the patient accordingly. An alternative to the current recommended lymph node sampling is the sentinel node procedure (SNP).
Methods
A systematic review was performed summarizing all published cases of SNP in addition to 13 cases from our hospital and 8 cases from two other hospitals that have not been published before.
Results
For all patients (
n
= 55), at least one SLN was identified, but the SNP technique used was not uniform. The SNP changed the nodal classification of eight patients (17.0%) and had a false-negative rate of 10.5%.
Conclusions
The SNP is recommendable for pediatric patients with extremity RMS. It can change lymph node status and can be used to sample patients in a more targeted way than nodal sampling alone. Therefore, we recommend use of the SNP in addition to clinical and radiological nodal assessment for pediatric patients with extremity RMS.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>34057567</pmid><doi>10.1245/s10434-021-10035-9</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7993-0208</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2021-12, Vol.28 (13), p.9048-9059 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Child Cohort analysis Extremities - pathology Extremities - surgery Humans Lymph Node Excision Lymph nodes Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic system Medicine Medicine & Public Health Metastases Neoplasm Staging Oncology Patients Pediatric Oncology Pediatrics Retrospective Studies Rhabdomyosarcoma Rhabdomyosarcoma - pathology Rhabdomyosarcoma - surgery Sampling Sentinel Lymph Node - pathology Sentinel Lymph Node - surgery Sentinel Lymph Node Biopsy Surgery Surgical Oncology Systematic review |
| title | Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma: A Systematic Review and Retrospective Cohort Study |
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