Epidemiology and Costs of Postsepsis Morbidity, Nursing Care Dependency, and Mortality in Germany, 2013 to 2017
Sepsis survivorship is associated with postsepsis morbidity, but epidemiological data from population-based cohorts are lacking. To quantify the frequency and co-occurrence of new diagnoses consistent with postsepsis morbidity and mortality as well as new nursing care dependency and total health car...
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| creator | Fleischmann-Struzek, Carolin Rose, Norman Freytag, Antje Spoden, Melissa Prescott, Hallie C Schettler, Anna Wedekind, Lisa Ditscheid, Bianka Storch, Josephine Born, Sebastian Schlattmann, Peter Günster, Christian Reinhart, Konrad Hartog, Christiane S |
| description | Sepsis survivorship is associated with postsepsis morbidity, but epidemiological data from population-based cohorts are lacking.
To quantify the frequency and co-occurrence of new diagnoses consistent with postsepsis morbidity and mortality as well as new nursing care dependency and total health care costs after sepsis.
This retrospective cohort study based on nationwide health claims data included a population-based cohort of 23.0 million beneficiaries of a large German health insurance provider. Patients aged 15 years and older with incident hospital-treated sepsis in 2013 to 2014 were included. Data were analyzed from January 2009 to December 2017.
Sepsis, identified by International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) hospital discharge codes.
New medical, psychological, and cognitive diagnoses; long-term mortality; dependency on nursing care; and overall health care costs in survivors at 1 to 12, 13 to 24, and 25 to 36 months after hospital discharge.
Among 23.0 million eligible individuals, we identified 159 684 patients hospitalized with sepsis in 2013 to 2014. The mean (SD) age was 73.8 (12.8) years, and 75 809 (47.5%; 95% CI, 47.2%-47.7%) were female patients. In-hospital mortality was 27.0% (43 177 patients; 95% CI, 26.8%-27.3%). Among 116 507 hospital survivors, 86 578 (74.3%; 95% CI, 74.1%-74.6%) had a new diagnosis in the first year post sepsis; 28 405 (24.4%; 95% CI, 24.1%-24.6%) had diagnoses co-occurring in medical, psychological, or cognitive domains; and 23 572 of 74 878 survivors (31.5%; 95% CI, 31.1%-31.8%) without prior nursing care dependency were newly dependent on nursing care. In total, 35 765 survivors (30.7%; 95% CI, 30.4%-31.0%) died within the first year. In the second and third year, 53 089 (65.8%; 95% CI, 65.4%-66.1%) and 40 959 (59.4%; 95% CI, 59.0%-59.8%) had new diagnoses, respectively. Health care costs for sepsis hospital survivors for 3 years post sepsis totaled a mean of €29 088/patient ($32 868/patient) (SD, €44 195 [$49 938]). New postsepsis morbidity (>1 new diagnosis) was more common in survivors of severe sepsis (75.6% [95% CI, 75.1%-76.0%]) than nonsevere sepsis (73.7% [95% CI, 73.4%-74.0%]; P |
| doi_str_mv | 10.1001/jamanetworkopen.2021.34290 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8590172</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2597487785</sourcerecordid><originalsourceid>FETCH-LOGICAL-a473t-86044482b61094f1e65c93a7fedcd6094f2600ee3a692473ea3a358bf8e9b5ed3</originalsourceid><addsrcrecordid>eNpdUU1P3DAQtVArQMBfQBa99MAu_nbSQyW0BYpEPw7t2XKSyeJtYgc7Kdp_j1M-RDnNyO-9mTd-CJ1QsqSE0LON7a2H8T7EP2EAv2SE0SUXrCQ7aJ9JLRa8IPLdq34PHaW0IYQwQnmp5C7a40IrTZjcR-FicA30LnRhvcXWN3gV0phwaPHPuYEhuYS_hVi5xo3bU_x9isn5NV7ZCPgLZAsN-DoDszbzRttlHnYeX0HMVjMy78VjmKs-RO9b2yU4eqoH6Pflxa_V18XNj6vr1fnNwgrNx0WhiBCiYJWipBQtBSXrklvdQlM3an5iihAAblXJsgIst1wWVVtAWUlo-AH6_Dh3mKo-i8CP0XZmiK63cWuCdeZ_xLtbsw5_TSHLbJPlAR-fBsRwN0EaTe9SDV2Xfz9MyTBZalFoXchM_fCGuglT9Pk8w5TSWlMmVWZ9emTVMaQUoX0xQ4mZozVvojVztOZftFl8_PqcF-lzkPwBnuCkTA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2667771256</pqid></control><display><type>article</type><title>Epidemiology and Costs of Postsepsis Morbidity, Nursing Care Dependency, and Mortality in Germany, 2013 to 2017</title><source>MEDLINE</source><source>Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Fleischmann-Struzek, Carolin ; Rose, Norman ; Freytag, Antje ; Spoden, Melissa ; Prescott, Hallie C ; Schettler, Anna ; Wedekind, Lisa ; Ditscheid, Bianka ; Storch, Josephine ; Born, Sebastian ; Schlattmann, Peter ; Günster, Christian ; Reinhart, Konrad ; Hartog, Christiane S</creator><creatorcontrib>Fleischmann-Struzek, Carolin ; Rose, Norman ; Freytag, Antje ; Spoden, Melissa ; Prescott, Hallie C ; Schettler, Anna ; Wedekind, Lisa ; Ditscheid, Bianka ; Storch, Josephine ; Born, Sebastian ; Schlattmann, Peter ; Günster, Christian ; Reinhart, Konrad ; Hartog, Christiane S</creatorcontrib><description>Sepsis survivorship is associated with postsepsis morbidity, but epidemiological data from population-based cohorts are lacking.
To quantify the frequency and co-occurrence of new diagnoses consistent with postsepsis morbidity and mortality as well as new nursing care dependency and total health care costs after sepsis.
This retrospective cohort study based on nationwide health claims data included a population-based cohort of 23.0 million beneficiaries of a large German health insurance provider. Patients aged 15 years and older with incident hospital-treated sepsis in 2013 to 2014 were included. Data were analyzed from January 2009 to December 2017.
Sepsis, identified by International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) hospital discharge codes.
New medical, psychological, and cognitive diagnoses; long-term mortality; dependency on nursing care; and overall health care costs in survivors at 1 to 12, 13 to 24, and 25 to 36 months after hospital discharge.
Among 23.0 million eligible individuals, we identified 159 684 patients hospitalized with sepsis in 2013 to 2014. The mean (SD) age was 73.8 (12.8) years, and 75 809 (47.5%; 95% CI, 47.2%-47.7%) were female patients. In-hospital mortality was 27.0% (43 177 patients; 95% CI, 26.8%-27.3%). Among 116 507 hospital survivors, 86 578 (74.3%; 95% CI, 74.1%-74.6%) had a new diagnosis in the first year post sepsis; 28 405 (24.4%; 95% CI, 24.1%-24.6%) had diagnoses co-occurring in medical, psychological, or cognitive domains; and 23 572 of 74 878 survivors (31.5%; 95% CI, 31.1%-31.8%) without prior nursing care dependency were newly dependent on nursing care. In total, 35 765 survivors (30.7%; 95% CI, 30.4%-31.0%) died within the first year. In the second and third year, 53 089 (65.8%; 95% CI, 65.4%-66.1%) and 40 959 (59.4%; 95% CI, 59.0%-59.8%) had new diagnoses, respectively. Health care costs for sepsis hospital survivors for 3 years post sepsis totaled a mean of €29 088/patient ($32 868/patient) (SD, €44 195 [$49 938]). New postsepsis morbidity (>1 new diagnosis) was more common in survivors of severe sepsis (75.6% [95% CI, 75.1%-76.0%]) than nonsevere sepsis (73.7% [95% CI, 73.4%-74.0%]; P < .001) and more common in survivors treated in the intensive care unit (78.3% [95% CI, 77.8%-78.7%]) than in those not treated in the intensive care unit (72.8% [95% CI, 72.5%-73.1%]; P < .001). Postsepsis morbidity was 68.5% (95% CI, 67.5%-69.5%) among survivors without prior morbidity and 56.1% (95% CI, 54.2%-57.9%) in survivors younger than 40 years.
In this study, new medical, psychological, and cognitive diagnoses consistent with postsepsis morbidity were common after sepsis, including among patients with less severe sepsis, no prior diagnoses, and younger age. This calls for more efforts to elucidate the underlying mechanisms, define optimal screening for common new diagnoses, and test interventions to prevent and treat postsepsis morbidity.</description><identifier>ISSN: 2574-3805</identifier><identifier>EISSN: 2574-3805</identifier><identifier>DOI: 10.1001/jamanetworkopen.2021.34290</identifier><identifier>PMID: 34767025</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Aged ; Cause of Death ; Cognition ; Critical Care Medicine ; Epidemiology ; Female ; Germany - epidemiology ; Health Care Costs ; Health care policy ; Hospital Mortality ; Hospitalization ; Hospitals ; Humans ; Intensive care ; Intensive Care Units ; International Classification of Diseases ; Long-Term Care ; Male ; Mental Disorders - epidemiology ; Mental Disorders - etiology ; Middle Aged ; Morbidity ; Mortality ; Nursing Care ; Nursing Homes ; Online Only ; Original Investigation ; Patient Discharge ; Patients ; Retrospective Studies ; Sepsis ; Sepsis - economics ; Sepsis - epidemiology ; Sepsis - mortality ; Severity of Illness Index ; Survivors - psychology</subject><ispartof>JAMA network open, 2021-11, Vol.4 (11), p.e2134290-e2134290</ispartof><rights>2021. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright 2021 Fleischmann-Struzek C et al. .</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a473t-86044482b61094f1e65c93a7fedcd6094f2600ee3a692473ea3a358bf8e9b5ed3</citedby><cites>FETCH-LOGICAL-a473t-86044482b61094f1e65c93a7fedcd6094f2600ee3a692473ea3a358bf8e9b5ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34767025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fleischmann-Struzek, Carolin</creatorcontrib><creatorcontrib>Rose, Norman</creatorcontrib><creatorcontrib>Freytag, Antje</creatorcontrib><creatorcontrib>Spoden, Melissa</creatorcontrib><creatorcontrib>Prescott, Hallie C</creatorcontrib><creatorcontrib>Schettler, Anna</creatorcontrib><creatorcontrib>Wedekind, Lisa</creatorcontrib><creatorcontrib>Ditscheid, Bianka</creatorcontrib><creatorcontrib>Storch, Josephine</creatorcontrib><creatorcontrib>Born, Sebastian</creatorcontrib><creatorcontrib>Schlattmann, Peter</creatorcontrib><creatorcontrib>Günster, Christian</creatorcontrib><creatorcontrib>Reinhart, Konrad</creatorcontrib><creatorcontrib>Hartog, Christiane S</creatorcontrib><title>Epidemiology and Costs of Postsepsis Morbidity, Nursing Care Dependency, and Mortality in Germany, 2013 to 2017</title><title>JAMA network open</title><addtitle>JAMA Netw Open</addtitle><description>Sepsis survivorship is associated with postsepsis morbidity, but epidemiological data from population-based cohorts are lacking.
To quantify the frequency and co-occurrence of new diagnoses consistent with postsepsis morbidity and mortality as well as new nursing care dependency and total health care costs after sepsis.
This retrospective cohort study based on nationwide health claims data included a population-based cohort of 23.0 million beneficiaries of a large German health insurance provider. Patients aged 15 years and older with incident hospital-treated sepsis in 2013 to 2014 were included. Data were analyzed from January 2009 to December 2017.
Sepsis, identified by International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) hospital discharge codes.
New medical, psychological, and cognitive diagnoses; long-term mortality; dependency on nursing care; and overall health care costs in survivors at 1 to 12, 13 to 24, and 25 to 36 months after hospital discharge.
Among 23.0 million eligible individuals, we identified 159 684 patients hospitalized with sepsis in 2013 to 2014. The mean (SD) age was 73.8 (12.8) years, and 75 809 (47.5%; 95% CI, 47.2%-47.7%) were female patients. In-hospital mortality was 27.0% (43 177 patients; 95% CI, 26.8%-27.3%). Among 116 507 hospital survivors, 86 578 (74.3%; 95% CI, 74.1%-74.6%) had a new diagnosis in the first year post sepsis; 28 405 (24.4%; 95% CI, 24.1%-24.6%) had diagnoses co-occurring in medical, psychological, or cognitive domains; and 23 572 of 74 878 survivors (31.5%; 95% CI, 31.1%-31.8%) without prior nursing care dependency were newly dependent on nursing care. In total, 35 765 survivors (30.7%; 95% CI, 30.4%-31.0%) died within the first year. In the second and third year, 53 089 (65.8%; 95% CI, 65.4%-66.1%) and 40 959 (59.4%; 95% CI, 59.0%-59.8%) had new diagnoses, respectively. Health care costs for sepsis hospital survivors for 3 years post sepsis totaled a mean of €29 088/patient ($32 868/patient) (SD, €44 195 [$49 938]). New postsepsis morbidity (>1 new diagnosis) was more common in survivors of severe sepsis (75.6% [95% CI, 75.1%-76.0%]) than nonsevere sepsis (73.7% [95% CI, 73.4%-74.0%]; P < .001) and more common in survivors treated in the intensive care unit (78.3% [95% CI, 77.8%-78.7%]) than in those not treated in the intensive care unit (72.8% [95% CI, 72.5%-73.1%]; P < .001). Postsepsis morbidity was 68.5% (95% CI, 67.5%-69.5%) among survivors without prior morbidity and 56.1% (95% CI, 54.2%-57.9%) in survivors younger than 40 years.
In this study, new medical, psychological, and cognitive diagnoses consistent with postsepsis morbidity were common after sepsis, including among patients with less severe sepsis, no prior diagnoses, and younger age. This calls for more efforts to elucidate the underlying mechanisms, define optimal screening for common new diagnoses, and test interventions to prevent and treat postsepsis morbidity.</description><subject>Aged</subject><subject>Cause of Death</subject><subject>Cognition</subject><subject>Critical Care Medicine</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Health Care Costs</subject><subject>Health care policy</subject><subject>Hospital Mortality</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intensive care</subject><subject>Intensive Care Units</subject><subject>International Classification of Diseases</subject><subject>Long-Term Care</subject><subject>Male</subject><subject>Mental Disorders - epidemiology</subject><subject>Mental Disorders - etiology</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Nursing Care</subject><subject>Nursing Homes</subject><subject>Online Only</subject><subject>Original Investigation</subject><subject>Patient Discharge</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Sepsis</subject><subject>Sepsis - economics</subject><subject>Sepsis - epidemiology</subject><subject>Sepsis - mortality</subject><subject>Severity of Illness Index</subject><subject>Survivors - psychology</subject><issn>2574-3805</issn><issn>2574-3805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdUU1P3DAQtVArQMBfQBa99MAu_nbSQyW0BYpEPw7t2XKSyeJtYgc7Kdp_j1M-RDnNyO-9mTd-CJ1QsqSE0LON7a2H8T7EP2EAv2SE0SUXrCQ7aJ9JLRa8IPLdq34PHaW0IYQwQnmp5C7a40IrTZjcR-FicA30LnRhvcXWN3gV0phwaPHPuYEhuYS_hVi5xo3bU_x9isn5NV7ZCPgLZAsN-DoDszbzRttlHnYeX0HMVjMy78VjmKs-RO9b2yU4eqoH6Pflxa_V18XNj6vr1fnNwgrNx0WhiBCiYJWipBQtBSXrklvdQlM3an5iihAAblXJsgIst1wWVVtAWUlo-AH6_Dh3mKo-i8CP0XZmiK63cWuCdeZ_xLtbsw5_TSHLbJPlAR-fBsRwN0EaTe9SDV2Xfz9MyTBZalFoXchM_fCGuglT9Pk8w5TSWlMmVWZ9emTVMaQUoX0xQ4mZozVvojVztOZftFl8_PqcF-lzkPwBnuCkTA</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Fleischmann-Struzek, Carolin</creator><creator>Rose, Norman</creator><creator>Freytag, Antje</creator><creator>Spoden, Melissa</creator><creator>Prescott, Hallie C</creator><creator>Schettler, Anna</creator><creator>Wedekind, Lisa</creator><creator>Ditscheid, Bianka</creator><creator>Storch, Josephine</creator><creator>Born, Sebastian</creator><creator>Schlattmann, Peter</creator><creator>Günster, Christian</creator><creator>Reinhart, Konrad</creator><creator>Hartog, Christiane S</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211101</creationdate><title>Epidemiology and Costs of Postsepsis Morbidity, Nursing Care Dependency, and Mortality in Germany, 2013 to 2017</title><author>Fleischmann-Struzek, Carolin ; Rose, Norman ; Freytag, Antje ; Spoden, Melissa ; Prescott, Hallie C ; Schettler, Anna ; Wedekind, Lisa ; Ditscheid, Bianka ; Storch, Josephine ; Born, Sebastian ; Schlattmann, Peter ; Günster, Christian ; Reinhart, Konrad ; Hartog, Christiane S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a473t-86044482b61094f1e65c93a7fedcd6094f2600ee3a692473ea3a358bf8e9b5ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Cause of Death</topic><topic>Cognition</topic><topic>Critical Care Medicine</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Germany - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAMA network open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fleischmann-Struzek, Carolin</au><au>Rose, Norman</au><au>Freytag, Antje</au><au>Spoden, Melissa</au><au>Prescott, Hallie C</au><au>Schettler, Anna</au><au>Wedekind, Lisa</au><au>Ditscheid, Bianka</au><au>Storch, Josephine</au><au>Born, Sebastian</au><au>Schlattmann, Peter</au><au>Günster, Christian</au><au>Reinhart, Konrad</au><au>Hartog, Christiane S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology and Costs of Postsepsis Morbidity, Nursing Care Dependency, and Mortality in Germany, 2013 to 2017</atitle><jtitle>JAMA network open</jtitle><addtitle>JAMA Netw Open</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>4</volume><issue>11</issue><spage>e2134290</spage><epage>e2134290</epage><pages>e2134290-e2134290</pages><issn>2574-3805</issn><eissn>2574-3805</eissn><abstract>Sepsis survivorship is associated with postsepsis morbidity, but epidemiological data from population-based cohorts are lacking.
To quantify the frequency and co-occurrence of new diagnoses consistent with postsepsis morbidity and mortality as well as new nursing care dependency and total health care costs after sepsis.
This retrospective cohort study based on nationwide health claims data included a population-based cohort of 23.0 million beneficiaries of a large German health insurance provider. Patients aged 15 years and older with incident hospital-treated sepsis in 2013 to 2014 were included. Data were analyzed from January 2009 to December 2017.
Sepsis, identified by International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) hospital discharge codes.
New medical, psychological, and cognitive diagnoses; long-term mortality; dependency on nursing care; and overall health care costs in survivors at 1 to 12, 13 to 24, and 25 to 36 months after hospital discharge.
Among 23.0 million eligible individuals, we identified 159 684 patients hospitalized with sepsis in 2013 to 2014. The mean (SD) age was 73.8 (12.8) years, and 75 809 (47.5%; 95% CI, 47.2%-47.7%) were female patients. In-hospital mortality was 27.0% (43 177 patients; 95% CI, 26.8%-27.3%). Among 116 507 hospital survivors, 86 578 (74.3%; 95% CI, 74.1%-74.6%) had a new diagnosis in the first year post sepsis; 28 405 (24.4%; 95% CI, 24.1%-24.6%) had diagnoses co-occurring in medical, psychological, or cognitive domains; and 23 572 of 74 878 survivors (31.5%; 95% CI, 31.1%-31.8%) without prior nursing care dependency were newly dependent on nursing care. In total, 35 765 survivors (30.7%; 95% CI, 30.4%-31.0%) died within the first year. In the second and third year, 53 089 (65.8%; 95% CI, 65.4%-66.1%) and 40 959 (59.4%; 95% CI, 59.0%-59.8%) had new diagnoses, respectively. Health care costs for sepsis hospital survivors for 3 years post sepsis totaled a mean of €29 088/patient ($32 868/patient) (SD, €44 195 [$49 938]). New postsepsis morbidity (>1 new diagnosis) was more common in survivors of severe sepsis (75.6% [95% CI, 75.1%-76.0%]) than nonsevere sepsis (73.7% [95% CI, 73.4%-74.0%]; P < .001) and more common in survivors treated in the intensive care unit (78.3% [95% CI, 77.8%-78.7%]) than in those not treated in the intensive care unit (72.8% [95% CI, 72.5%-73.1%]; P < .001). Postsepsis morbidity was 68.5% (95% CI, 67.5%-69.5%) among survivors without prior morbidity and 56.1% (95% CI, 54.2%-57.9%) in survivors younger than 40 years.
In this study, new medical, psychological, and cognitive diagnoses consistent with postsepsis morbidity were common after sepsis, including among patients with less severe sepsis, no prior diagnoses, and younger age. This calls for more efforts to elucidate the underlying mechanisms, define optimal screening for common new diagnoses, and test interventions to prevent and treat postsepsis morbidity.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>34767025</pmid><doi>10.1001/jamanetworkopen.2021.34290</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Cause of Death Cognition Critical Care Medicine Epidemiology Female Germany - epidemiology Health Care Costs Health care policy Hospital Mortality Hospitalization Hospitals Humans Intensive care Intensive Care Units International Classification of Diseases Long-Term Care Male Mental Disorders - epidemiology Mental Disorders - etiology Middle Aged Morbidity Mortality Nursing Care Nursing Homes Online Only Original Investigation Patient Discharge Patients Retrospective Studies Sepsis Sepsis - economics Sepsis - epidemiology Sepsis - mortality Severity of Illness Index Survivors - psychology |
| title | Epidemiology and Costs of Postsepsis Morbidity, Nursing Care Dependency, and Mortality in Germany, 2013 to 2017 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T05%3A49%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epidemiology%20and%20Costs%20of%20Postsepsis%20Morbidity,%20Nursing%20Care%20Dependency,%20and%20Mortality%20in%20Germany,%202013%20to%202017&rft.jtitle=JAMA%20network%20open&rft.au=Fleischmann-Struzek,%20Carolin&rft.date=2021-11-01&rft.volume=4&rft.issue=11&rft.spage=e2134290&rft.epage=e2134290&rft.pages=e2134290-e2134290&rft.issn=2574-3805&rft.eissn=2574-3805&rft_id=info:doi/10.1001/jamanetworkopen.2021.34290&rft_dat=%3Cproquest_pubme%3E2597487785%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2667771256&rft_id=info:pmid/34767025&rfr_iscdi=true |