A new GABAergic somatostatin projection from the BNST onto accumbal parvalbumin neurons controls anxiety

The prevailing view is that parvalbumin (PV) interneurons play modulatory roles in emotional response through local medium spiny projection neurons (MSNs). Here, we show that PV activity within the nucleus accumbens shell (sNAc) is required for producing anxiety-like avoidance when mice are under an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular psychiatry 2021-09, Vol.26 (9), p.4719-4741
Hauptverfasser:	Xiao, Qian, Zhou, Xinyi, Wei, Pengfei, Xie, Li, Han, Yaning, Wang, Jie, Cai, Aoling, Xu, Fuqiang, Tu, Jie, Wang, Liping
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/19 14/32 59/36 631/378 631/443 64/60 9/30 9/74 Amygdala (Brain) Animal models Animals Anxiety Avoidance behavior Behavioral Sciences Biological Psychology Development and progression Excitability GABA GABAergic Neurons Health aspects Interneurons Medicine Medicine & Public Health Mice Neural circuitry Neurons Neurosciences Nucleus accumbens Parvalbumin Parvalbumins Pharmacotherapy Physiological aspects Psychiatry Psychological aspects Sensory neurons Somatostatin Stria terminalis Synapses Synaptic transmission Therapeutic applications γ-Aminobutyric acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!