Shenjinhuoxue Mixture Attenuates Inflammation, Pain, and Cartilage Degeneration by Inhibiting TLR-4 and NF-κB Activation in Rats with Osteoarthritis: A Synergistic Combination of Multitarget Active Phytochemicals

Osteoarthritis (OA), a highly prevalent chronic joint disease, involves a complex network of inflammatory mediators that not only triggers pain and cartilage degeneration but also accelerates disease progression. Traditional Chinese medicinal shenjinhuoxue mixture (SHM) shows anti-inflammatory and a...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.4190098
Hauptverfasser:	Ma, Xiaoqin, Hao, Chenxia, Zhang, Zhaokang, Jiang, Huiting, Zhang, Weixia, Huang, Jingjing, Chen, Xiaofei, Yang, Wanhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Arthritis Cartilage Cartilage Diseases - etiology Cartilage Diseases - metabolism Cartilage Diseases - pathology Cartilage Diseases - prevention & control Chinese medicine Cultural heritage Cytokines Disease Models, Animal Genomes Herbs Hyperalgesia Inflammation Inflammation - etiology Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Ligands Male Medicine, Chinese Traditional Mice Mice, Inbred C57BL NF-kappa B - antagonists & inhibitors Osteoarthritis Osteoarthritis - complications Pain Pain - etiology Pain - metabolism Pain - pathology Pain - prevention & control Phytochemicals Phytochemicals - pharmacology Plant Extracts - pharmacology Protective Agents - pharmacology Proteins Sensors Software Surfactants Toll-Like Receptor 4 - antagonists & inhibitors Tumor necrosis factor-TNF
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