The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy
The mitochondrial-associated endoplasmic reticulum membrane (MAM) is located between the outer mitochondrial membrane and the endoplasmic reticulum membrane. The MAM is involved in a wide range of cellular functions, including calcium signaling, the division and fusion of mitochondria, endoplasmic r...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.8054817-8054817 |
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| creator | Ni, Lihua Yuan, Cheng |
| description | The mitochondrial-associated endoplasmic reticulum membrane (MAM) is located between the outer mitochondrial membrane and the endoplasmic reticulum membrane. The MAM is involved in a wide range of cellular functions, including calcium signaling, the division and fusion of mitochondria, endoplasmic reticulum stress, and the synthesis and transport of lipids. Recent studies have discovered that the MAM is involved in the pathogenesis of diabetic nephropathy (DN). In this article, we summarize the structure, function and role of the MAM in DN. We hope this study will provide clues and a theoretical basis for mechanistic and targeted drug research on DN. |
| doi_str_mv | 10.1155/2021/8054817 |
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The MAM is involved in a wide range of cellular functions, including calcium signaling, the division and fusion of mitochondria, endoplasmic reticulum stress, and the synthesis and transport of lipids. Recent studies have discovered that the MAM is involved in the pathogenesis of diabetic nephropathy (DN). In this article, we summarize the structure, function and role of the MAM in DN. We hope this study will provide clues and a theoretical basis for mechanistic and targeted drug research on DN.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2021/8054817</identifier><identifier>PMID: 34777695</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Animals ; Apoptosis ; Autophagy ; Biosynthesis ; Cell Membrane - chemistry ; Cholesterol ; Diabetes ; Diabetic Nephropathies - pathology ; Diabetic nephropathy ; Endoplasmic reticulum ; Endoplasmic Reticulum - chemistry ; Enzymes ; Fatty acids ; Homeostasis ; Humans ; Kinases ; Lipids ; Metabolism ; Microscopy ; Mitochondria ; Mitochondria - pathology ; Mortality ; Proteins ; Review</subject><ispartof>Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.8054817-8054817</ispartof><rights>Copyright © 2021 Lihua Ni and Cheng Yuan.</rights><rights>Copyright © 2021 Lihua Ni and Cheng Yuan. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Apoptosis Autophagy Biosynthesis Cell Membrane - chemistry Cholesterol Diabetes Diabetic Nephropathies - pathology Diabetic nephropathy Endoplasmic reticulum Endoplasmic Reticulum - chemistry Enzymes Fatty acids Homeostasis Humans Kinases Lipids Metabolism Microscopy Mitochondria Mitochondria - pathology Mortality Proteins Review |
| title | The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy |
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