Gasdermin D pore structure reveals preferential release of mature interleukin-1

As organelles of the innate immune system, inflammasomes activate caspase-1 and other inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive precursors of the interleukin (IL)-1 family to generate mature cytokines such as IL-1β and IL-18. Cleaved GSDMD forms transmemb...

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Veröffentlicht in:	Nature (London) 2021-05, Vol.593 (7860), p.607-611
Hauptverfasser:	Xia, Shiyu, Zhang, Zhibin, Magupalli, Venkat Giri, Pablo, Juan Lorenzo, Dong, Ying, Vora, Setu M., Wang, Longfei, Fu, Tian-Min, Jacobson, Matthew P., Greka, Anna, Lieberman, Judy, Ruan, Jianbin, Wu, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/250/262 631/535/1258/1259 Animals Caspase 1 - metabolism Caspase-1 Cell organelles Channel pores Cryoelectron Microscopy Cytokines Electron microscopy Humanities and Social Sciences Humans Hydrophobicity Immune system Inflammasomes Inflammasomes - chemistry Inflammation Innate immunity Interleukin 1 Interleukin-1 - metabolism Interleukin-1beta - metabolism Intracellular Signaling Peptides and Proteins - chemistry Lipids Lysis Macrophages Macrophages - metabolism Mice Mice, Inbred C57BL Microscopy multidisciplinary Mutation Organelles Phosphate-Binding Proteins - chemistry Physiological aspects Pores Precursors Protein Precursors - metabolism Protein Structure, Quaternary Proteins Science Science (multidisciplinary) Static Electricity Structure
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