New Steroidal Saponins Isolated from the Rhizomes of Paris mairei
The genus Paris is an excellent source of steroidal saponins that exhibit various bioactivities. Paris mairei is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins,...
Gespeichert in:
| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2021-10, Vol.26 (21), p.6366, Article 6366 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 21 |
| container_start_page | 6366 |
| container_title | Molecules (Basel, Switzerland) |
| container_volume | 26 |
| creator | Liu, Yang Qiu, Pengcheng Wang, Minchang Lu, Yunyang He, Hao Tang, Haifeng Zhang, Bang-Le |
| description | The genus Paris is an excellent source of steroidal saponins that exhibit various bioactivities. Paris mairei is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A-E (1-5), along with five known steroidal saponins 6-10, were isolated from the rhizomes of Paris mairei. The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines. |
| doi_str_mv | 10.3390/molecules26216366 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8588014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_b929b14d73444735952ca84585801955</doaj_id><sourcerecordid>2596050039</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-aaab66d7dde3061a802a7864a8b32b41e26b36171591580bda7a9a3316acd6c3</originalsourceid><addsrcrecordid>eNqNkV1rFDEUhgdRbK3-AG9kwBtBVvOdyY1QFj8WiortfTiTnO1mmZmsSaZFf72pW5dWb7zKIXnehyRv0zyn5A3nhrwd44BuHjAzxajiSj1ojqlgZMGJMA_vzEfNk5y3hDAqqHzcHHGhNdGaHzenn_G6PS-YYvAwtOewi1OYcrvKcYCCvl2nOLZlg-23TfgZR8xtXLdfIYXcjhAShqfNozUMGZ_drifNxYf3F8tPi7MvH1fL07OFE4aXBQD0SnntPXKiKHSEge6UgK7nrBcUmeq5oppKQ2VHeg8aDHBOFTivHD9pVnutj7C1uxRGSD9shGB_b8R0aSGV4Aa0vWGmp8JrLoTQXBrJHHRCdtVLjZTV9W7v2s39iN7hVBIM96T3T6awsZfxylZDVYgqeHUrSPH7jLnYMWSHwwATxjlbJo0WndCMVPTlX-g2zmmqP3VDKSIJ4aZSdE-5FHNOuD5chhJ707X9p-uaeXH3FYfEn3Ir0O2Ba-zjOruAk8MDRgjRjFLKRZ0IXYYCJcRpGeep1Ojr_4_yXxFaxeo</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2596050039</pqid></control><display><type>article</type><title>New Steroidal Saponins Isolated from the Rhizomes of Paris mairei</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Liu, Yang ; Qiu, Pengcheng ; Wang, Minchang ; Lu, Yunyang ; He, Hao ; Tang, Haifeng ; Zhang, Bang-Le</creator><creatorcontrib>Liu, Yang ; Qiu, Pengcheng ; Wang, Minchang ; Lu, Yunyang ; He, Hao ; Tang, Haifeng ; Zhang, Bang-Le</creatorcontrib><description>The genus Paris is an excellent source of steroidal saponins that exhibit various bioactivities. Paris mairei is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A-E (1-5), along with five known steroidal saponins 6-10, were isolated from the rhizomes of Paris mairei. The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules26216366</identifier><identifier>PMID: 34770773</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject><![CDATA[15-oxo-18-nor-spirost ; Adenocarcinoma ; Aquatic plants ; Biochemistry & Molecular Biology ; Biocompatibility ; Carbon ; Cell Line, Tumor ; Cell Survival - drug effects ; Chemical Fractionation ; Chemical reactions ; Chemistry ; Chemistry, Multidisciplinary ; Cytotoxicity ; Humans ; Inhibitory Concentration 50 ; Life Sciences & Biomedicine ; Melanthiaceae - chemistry ; Molecular Structure ; Pancreatic cancer ; Paris mairei ; Physical Sciences ; Phytosterols - chemistry ; Phytosterols - isolation & purification ; Phytosterols - pharmacology ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Rhizome - chemistry ; Rhizomes ; Saponins ; Saponins - chemistry ; Saponins - isolation & purification ; Saponins - pharmacology ; Science & Technology ; Spectrum Analysis ; spirostane saponin ; steroidal saponins ; Tumor cell lines]]></subject><ispartof>Molecules (Basel, Switzerland), 2021-10, Vol.26 (21), p.6366, Article 6366</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>7</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000721113400001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c493t-aaab66d7dde3061a802a7864a8b32b41e26b36171591580bda7a9a3316acd6c3</citedby><cites>FETCH-LOGICAL-c493t-aaab66d7dde3061a802a7864a8b32b41e26b36171591580bda7a9a3316acd6c3</cites><orcidid>0000-0002-4826-4094</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588014/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588014/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34770773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Qiu, Pengcheng</creatorcontrib><creatorcontrib>Wang, Minchang</creatorcontrib><creatorcontrib>Lu, Yunyang</creatorcontrib><creatorcontrib>He, Hao</creatorcontrib><creatorcontrib>Tang, Haifeng</creatorcontrib><creatorcontrib>Zhang, Bang-Le</creatorcontrib><title>New Steroidal Saponins Isolated from the Rhizomes of Paris mairei</title><title>Molecules (Basel, Switzerland)</title><addtitle>MOLECULES</addtitle><addtitle>Molecules</addtitle><description>The genus Paris is an excellent source of steroidal saponins that exhibit various bioactivities. Paris mairei is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A-E (1-5), along with five known steroidal saponins 6-10, were isolated from the rhizomes of Paris mairei. The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines.</description><subject>15-oxo-18-nor-spirost</subject><subject>Adenocarcinoma</subject><subject>Aquatic plants</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biocompatibility</subject><subject>Carbon</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Chemical Fractionation</subject><subject>Chemical reactions</subject><subject>Chemistry</subject><subject>Chemistry, Multidisciplinary</subject><subject>Cytotoxicity</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Life Sciences & Biomedicine</subject><subject>Melanthiaceae - chemistry</subject><subject>Molecular Structure</subject><subject>Pancreatic cancer</subject><subject>Paris mairei</subject><subject>Physical Sciences</subject><subject>Phytosterols - chemistry</subject><subject>Phytosterols - isolation & purification</subject><subject>Phytosterols - pharmacology</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Rhizome - chemistry</subject><subject>Rhizomes</subject><subject>Saponins</subject><subject>Saponins - chemistry</subject><subject>Saponins - isolation & purification</subject><subject>Saponins - pharmacology</subject><subject>Science & Technology</subject><subject>Spectrum Analysis</subject><subject>spirostane saponin</subject><subject>steroidal saponins</subject><subject>Tumor cell lines</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkV1rFDEUhgdRbK3-AG9kwBtBVvOdyY1QFj8WiortfTiTnO1mmZmsSaZFf72pW5dWb7zKIXnehyRv0zyn5A3nhrwd44BuHjAzxajiSj1ojqlgZMGJMA_vzEfNk5y3hDAqqHzcHHGhNdGaHzenn_G6PS-YYvAwtOewi1OYcrvKcYCCvl2nOLZlg-23TfgZR8xtXLdfIYXcjhAShqfNozUMGZ_drifNxYf3F8tPi7MvH1fL07OFE4aXBQD0SnntPXKiKHSEge6UgK7nrBcUmeq5oppKQ2VHeg8aDHBOFTivHD9pVnutj7C1uxRGSD9shGB_b8R0aSGV4Aa0vWGmp8JrLoTQXBrJHHRCdtVLjZTV9W7v2s39iN7hVBIM96T3T6awsZfxylZDVYgqeHUrSPH7jLnYMWSHwwATxjlbJo0WndCMVPTlX-g2zmmqP3VDKSIJ4aZSdE-5FHNOuD5chhJ707X9p-uaeXH3FYfEn3Ir0O2Ba-zjOruAk8MDRgjRjFLKRZ0IXYYCJcRpGeep1Ojr_4_yXxFaxeo</recordid><startdate>20211021</startdate><enddate>20211021</enddate><creator>Liu, Yang</creator><creator>Qiu, Pengcheng</creator><creator>Wang, Minchang</creator><creator>Lu, Yunyang</creator><creator>He, Hao</creator><creator>Tang, Haifeng</creator><creator>Zhang, Bang-Le</creator><general>Mdpi</general><general>MDPI AG</general><general>MDPI</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4826-4094</orcidid></search><sort><creationdate>20211021</creationdate><title>New Steroidal Saponins Isolated from the Rhizomes of Paris mairei</title><author>Liu, Yang ; Qiu, Pengcheng ; Wang, Minchang ; Lu, Yunyang ; He, Hao ; Tang, Haifeng ; Zhang, Bang-Le</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-aaab66d7dde3061a802a7864a8b32b41e26b36171591580bda7a9a3316acd6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>15-oxo-18-nor-spirost</topic><topic>Adenocarcinoma</topic><topic>Aquatic plants</topic><topic>Biochemistry & Molecular Biology</topic><topic>Biocompatibility</topic><topic>Carbon</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Chemical Fractionation</topic><topic>Chemical reactions</topic><topic>Chemistry</topic><topic>Chemistry, Multidisciplinary</topic><topic>Cytotoxicity</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Life Sciences & Biomedicine</topic><topic>Melanthiaceae - chemistry</topic><topic>Molecular Structure</topic><topic>Pancreatic cancer</topic><topic>Paris mairei</topic><topic>Physical Sciences</topic><topic>Phytosterols - chemistry</topic><topic>Phytosterols - isolation & purification</topic><topic>Phytosterols - pharmacology</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Rhizome - chemistry</topic><topic>Rhizomes</topic><topic>Saponins</topic><topic>Saponins - chemistry</topic><topic>Saponins - isolation & purification</topic><topic>Saponins - pharmacology</topic><topic>Science & Technology</topic><topic>Spectrum Analysis</topic><topic>spirostane saponin</topic><topic>steroidal saponins</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Qiu, Pengcheng</creatorcontrib><creatorcontrib>Wang, Minchang</creatorcontrib><creatorcontrib>Lu, Yunyang</creatorcontrib><creatorcontrib>He, Hao</creatorcontrib><creatorcontrib>Tang, Haifeng</creatorcontrib><creatorcontrib>Zhang, Bang-Le</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yang</au><au>Qiu, Pengcheng</au><au>Wang, Minchang</au><au>Lu, Yunyang</au><au>He, Hao</au><au>Tang, Haifeng</au><au>Zhang, Bang-Le</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Steroidal Saponins Isolated from the Rhizomes of Paris mairei</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><stitle>MOLECULES</stitle><addtitle>Molecules</addtitle><date>2021-10-21</date><risdate>2021</risdate><volume>26</volume><issue>21</issue><spage>6366</spage><pages>6366-</pages><artnum>6366</artnum><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>The genus Paris is an excellent source of steroidal saponins that exhibit various bioactivities. Paris mairei is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A-E (1-5), along with five known steroidal saponins 6-10, were isolated from the rhizomes of Paris mairei. The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>34770773</pmid><doi>10.3390/molecules26216366</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-4826-4094</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1420-3049 |
| ispartof | Molecules (Basel, Switzerland), 2021-10, Vol.26 (21), p.6366, Article 6366 |
| issn | 1420-3049 1420-3049 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8588014 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; MDPI - Multidisciplinary Digital Publishing Institute; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 15-oxo-18-nor-spirost Adenocarcinoma Aquatic plants Biochemistry & Molecular Biology Biocompatibility Carbon Cell Line, Tumor Cell Survival - drug effects Chemical Fractionation Chemical reactions Chemistry Chemistry, Multidisciplinary Cytotoxicity Humans Inhibitory Concentration 50 Life Sciences & Biomedicine Melanthiaceae - chemistry Molecular Structure Pancreatic cancer Paris mairei Physical Sciences Phytosterols - chemistry Phytosterols - isolation & purification Phytosterols - pharmacology Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Rhizome - chemistry Rhizomes Saponins Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Science & Technology Spectrum Analysis spirostane saponin steroidal saponins Tumor cell lines |
| title | New Steroidal Saponins Isolated from the Rhizomes of Paris mairei |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T00%3A38%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20Steroidal%20Saponins%20Isolated%20from%20the%20Rhizomes%20of%20Paris%20mairei&rft.jtitle=Molecules%20(Basel,%20Switzerland)&rft.au=Liu,%20Yang&rft.date=2021-10-21&rft.volume=26&rft.issue=21&rft.spage=6366&rft.pages=6366-&rft.artnum=6366&rft.issn=1420-3049&rft.eissn=1420-3049&rft_id=info:doi/10.3390/molecules26216366&rft_dat=%3Cproquest_pubme%3E2596050039%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2596050039&rft_id=info:pmid/34770773&rft_doaj_id=oai_doaj_org_article_b929b14d73444735952ca84585801955&rfr_iscdi=true |