New Steroidal Saponins Isolated from the Rhizomes of Paris mairei

The genus Paris is an excellent source of steroidal saponins that exhibit various bioactivities. Paris mairei is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins,...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2021-10, Vol.26 (21), p.6366, Article 6366
Hauptverfasser:	Liu, Yang, Qiu, Pengcheng, Wang, Minchang, Lu, Yunyang, He, Hao, Tang, Haifeng, Zhang, Bang-Le
Format:	Artikel
Sprache:	eng
Schlagworte:	15-oxo-18-nor-spirost Adenocarcinoma Aquatic plants Biochemistry & Molecular Biology Biocompatibility Carbon Cell Line, Tumor Cell Survival - drug effects Chemical Fractionation Chemical reactions Chemistry Chemistry, Multidisciplinary Cytotoxicity Humans Inhibitory Concentration 50 Life Sciences & Biomedicine Melanthiaceae - chemistry Molecular Structure Pancreatic cancer Paris mairei Physical Sciences Phytosterols - chemistry Phytosterols - isolation & purification Phytosterols - pharmacology Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Rhizome - chemistry Rhizomes Saponins Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Science & Technology Spectrum Analysis spirostane saponin steroidal saponins Tumor cell lines
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Zusammenfassung:	The genus Paris is an excellent source of steroidal saponins that exhibit various bioactivities. Paris mairei is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A-E (1-5), along with five known steroidal saponins 6-10, were isolated from the rhizomes of Paris mairei. The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules26216366