Combination of Analytical and Statistical Methods in Order to Optimize Antibacterial Activity of Clary Sage Supercritical Fluid Extracts
The extraction of clary sage (Salvia sclarea L.) using supercritical carbon dioxide (SC-CO2) was systematically studied by using thin layer chromatography-direct bioautography (TLC-DB) and response surface methodology (RSM). The three parameters temperature, pressure, and cosolvent ratio were optimi...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2021-10, Vol.26 (21), p.6449, Article 6449 |
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| creator | Bako, Csongor Balazs, Viktoria Lilla Takacs, Gyoengyi Pallos, Jozsef Peter Pal, Szilard Kocsis, Bela Petho, Dora Rippelne Horvath, Gyoergyi |
| description | The extraction of clary sage (Salvia sclarea L.) using supercritical carbon dioxide (SC-CO2) was systematically studied by using thin layer chromatography-direct bioautography (TLC-DB) and response surface methodology (RSM). The three parameters temperature, pressure, and cosolvent ratio were optimized for the maximum antibacterial activity of clary sage extracts against Pseudomonas aeruginosa (P. aeruginosa) and methicillin-resistant Staphylococcus aureus (MRSA). The highest inhibition zone was 7.51 mm for P. aeruginosa and 7.57 mm for MRSA. According to RSM analysis, the predicted optimum extraction parameters are 18.6 MPa pressure, 40 & DEG;C temperature, and 2% ethanol (EtOH) ratio. The combination of this analytical and statistical method allows saving time, money, and instrument runtime in the optimization of essential oil composition, which is tailored to a specific task and could be useful on any kind of herbs in a wide range of use from perfume manufacturing to the food industry. |
| doi_str_mv | 10.3390/molecules26216449 |
| format | Article |
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The three parameters temperature, pressure, and cosolvent ratio were optimized for the maximum antibacterial activity of clary sage extracts against Pseudomonas aeruginosa (P. aeruginosa) and methicillin-resistant Staphylococcus aureus (MRSA). The highest inhibition zone was 7.51 mm for P. aeruginosa and 7.57 mm for MRSA. According to RSM analysis, the predicted optimum extraction parameters are 18.6 MPa pressure, 40 & DEG;C temperature, and 2% ethanol (EtOH) ratio. The combination of this analytical and statistical method allows saving time, money, and instrument runtime in the optimization of essential oil composition, which is tailored to a specific task and could be useful on any kind of herbs in a wide range of use from perfume manufacturing to the food industry.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules26216449</identifier><identifier>PMID: 34770858</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Antibiotics ; Antimicrobial agents ; Bacteria ; Biochemistry & Molecular Biology ; Carbon dioxide ; Carbon Dioxide - chemistry ; Chemical composition ; Chemistry ; Chemistry, Multidisciplinary ; Chromatography ; Chromatography, Supercritical Fluid ; clary sage ; Drug resistance ; Essential oils ; Ethanol ; Food industry ; Life Sciences & Biomedicine ; Methicillin ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Methods ; Microbial Sensitivity Tests ; Oils & fats ; Optimization ; Pathogens ; Physical Sciences ; Product development ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; response surface method ; Response surface methodology ; Salvia - chemistry ; Science & Technology ; Staphylococcus aureus ; Staphylococcus infections ; Statistical methods ; Statistics ; supercritical fluid extraction ; Supercritical fluids ; Thin layer chromatography ; thin layer chromatography-direct bioautography</subject><ispartof>Molecules (Basel, Switzerland), 2021-10, Vol.26 (21), p.6449, Article 6449</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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The combination of this analytical and statistical method allows saving time, money, and instrument runtime in the optimization of essential oil composition, which is tailored to a specific task and could be useful on any kind of herbs in a wide range of use from perfume manufacturing to the food industry.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Biochemistry & Molecular Biology</subject><subject>Carbon dioxide</subject><subject>Carbon Dioxide - chemistry</subject><subject>Chemical composition</subject><subject>Chemistry</subject><subject>Chemistry, Multidisciplinary</subject><subject>Chromatography</subject><subject>Chromatography, Supercritical Fluid</subject><subject>clary sage</subject><subject>Drug resistance</subject><subject>Essential oils</subject><subject>Ethanol</subject><subject>Food industry</subject><subject>Life Sciences & Biomedicine</subject><subject>Methicillin</subject><subject>Methicillin-Resistant Staphylococcus aureus - 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chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Biochemistry & Molecular Biology</topic><topic>Carbon dioxide</topic><topic>Carbon Dioxide - chemistry</topic><topic>Chemical composition</topic><topic>Chemistry</topic><topic>Chemistry, Multidisciplinary</topic><topic>Chromatography</topic><topic>Chromatography, Supercritical Fluid</topic><topic>clary sage</topic><topic>Drug resistance</topic><topic>Essential oils</topic><topic>Ethanol</topic><topic>Food industry</topic><topic>Life Sciences & Biomedicine</topic><topic>Methicillin</topic><topic>Methicillin-Resistant Staphylococcus aureus - drug effects</topic><topic>Methods</topic><topic>Microbial Sensitivity Tests</topic><topic>Oils & fats</topic><topic>Optimization</topic><topic>Pathogens</topic><topic>Physical Sciences</topic><topic>Product development</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - 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The three parameters temperature, pressure, and cosolvent ratio were optimized for the maximum antibacterial activity of clary sage extracts against Pseudomonas aeruginosa (P. aeruginosa) and methicillin-resistant Staphylococcus aureus (MRSA). The highest inhibition zone was 7.51 mm for P. aeruginosa and 7.57 mm for MRSA. According to RSM analysis, the predicted optimum extraction parameters are 18.6 MPa pressure, 40 & DEG;C temperature, and 2% ethanol (EtOH) ratio. The combination of this analytical and statistical method allows saving time, money, and instrument runtime in the optimization of essential oil composition, which is tailored to a specific task and could be useful on any kind of herbs in a wide range of use from perfume manufacturing to the food industry.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>34770858</pmid><doi>10.3390/molecules26216449</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-5344-0294</orcidid><orcidid>https://orcid.org/0000-0003-1508-4019</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial activity Antibiotics Antimicrobial agents Bacteria Biochemistry & Molecular Biology Carbon dioxide Carbon Dioxide - chemistry Chemical composition Chemistry Chemistry, Multidisciplinary Chromatography Chromatography, Supercritical Fluid clary sage Drug resistance Essential oils Ethanol Food industry Life Sciences & Biomedicine Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Methods Microbial Sensitivity Tests Oils & fats Optimization Pathogens Physical Sciences Product development Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects response surface method Response surface methodology Salvia - chemistry Science & Technology Staphylococcus aureus Staphylococcus infections Statistical methods Statistics supercritical fluid extraction Supercritical fluids Thin layer chromatography thin layer chromatography-direct bioautography |
| title | Combination of Analytical and Statistical Methods in Order to Optimize Antibacterial Activity of Clary Sage Supercritical Fluid Extracts |
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