Identification of Spiro-Fused Pyrrolo[3,4- a ]pyrrolizines and Tryptanthrines as Potential Antitumor Agents: Synthesis and In Vitro Evaluation

A series of heterocyclic compounds containing a spiro-fused pyrrolo[3,4- ]pyrrolizine and tryptanthrin framework have been synthesized and studied as potential antitumor agents. Cytotoxicity of products was screened against human erythroleukemia (K562) and human cervical carcinoma (HeLa) cell lines....

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Veröffentlicht in:	International journal of molecular sciences 2021-11, Vol.22 (21), p.11997
Hauptverfasser:	Latypova, Diana K, Shmakov, Stanislav V, Pechkovskaya, Sofya A, Filatov, Alexander S, Stepakov, Alexander V, Knyazev, Nickolay A, Boitsov, Vitali M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cancer Cell cycle Cell Cycle - drug effects Cell death Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cervical cancer Cervical carcinoma Cervix Chromatography Confocal microscopy Cystic fibrosis Cytometry Cytoplasm Cytotoxicity Drug resistance Drug Screening Assays, Antitumor Erythroleukemia Female Filaments Heterocyclic compounds Humans Leukemia, Erythroblastic, Acute - drug therapy Leukemia, Erythroblastic, Acute - metabolism Leukemia, Erythroblastic, Acute - pathology Morphology Natural products Pyrrolidines - chemical synthesis Pyrrolidines - pharmacology Quinazolines - chemical synthesis Quinazolines - pharmacology Spiro Compounds - chemical synthesis Spiro Compounds - pharmacology Tumor cell lines Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology
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