Dual Role of Thrombospondin-1 in Flow-Induced Remodeling

(1) Background: Chronic increases in blood flow, as in cardiovascular diseases, induce outward arterial remodeling. Thrombospondin-1 (TSP-1) is known to interact with matrix proteins and immune cell-surface receptors, but its contribution to flow-mediated remodeling in the microcirculation remains u...

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Veröffentlicht in:	International journal of molecular sciences 2021-11, Vol.22 (21), p.12086
Hauptverfasser:	Grenier, Céline, Caillon, Antoine, Munier, Mathilde, Grimaud, Linda, Champin, Tristan, Toutain, Bertrand, Fassot, Céline, Blanc-Brude, Olivier, Loufrani, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries Biochemistry, Molecular Biology Blood flow Bone marrow Cardiology and cardiovascular system Cardiovascular diseases Cell surface Cyclooxygenase-2 Endothelium, Vascular - metabolism Gene expression Human health and pathology Hypertension Immune system In vivo methods and tests Inflammation Leukocytes (neutrophilic) Life Sciences Mesenteric Arteries - metabolism Mesenteric Arteries - physiology Mice Mice, Knockout Microcirculation Models, Animal Neutropenia Neutrophils Pressure effects Regional Blood Flow Rodents Shear stress Smooth muscle Thrombospondin Thrombospondin 1 - genetics Thrombospondin 1 - metabolism Vasodilation Veins & arteries
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