Identification of DNA Damage Repair-Associated Prognostic Biomarkers for Prostate Cancer Using Transcriptomic Data Analysis

In the recent decade, the importance of DNA damage repair (DDR) and its clinical application have been firmly recognized in prostate cancer (PC). For example, olaparib was just approved in May 2020 to treat metastatic castration-resistant PC with homologous recombination repair-mutated genes; howeve...

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Veröffentlicht in:	International journal of molecular sciences 2021-10, Vol.22 (21), p.11771
Hauptverfasser:	Teng, Pai-Chi, Huang, Shu-Pin, Liu, Chia-Hsin, Lin, Ting-Yi, Cho, Yi-Chun, Lai, Yo-Liang, Wang, Shu-Chi, Yeh, Hsin-Chih, Chuu, Chih-Pin, Chen, Deng-Neng, Cheng, Wei-Chung, Li, Chia-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Anemia Biology Biomarkers Biomarkers, Tumor - genetics Cancer therapies Castration Damage detection Deoxyribonucleic acid DNA DNA Damage DNA Repair Enzymes FDA approval Gene expression Gene Expression Profiling Genes Homologous recombination Homologous recombination repair Homology Humans Male Metastases Metastasis Mutation Patients Prognosis Prostate cancer Prostatic Neoplasms - diagnosis Prostatic Neoplasms - genetics Repair Survival Survival analysis Transcriptome Transcriptomics
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