Mitochondrial Effects in the Liver of C57BL/6 Mice by Low Dose, High Energy, High Charge Irradiation

Galactic cosmic rays are primarily composed of protons (85%), helium (14%), and high charge/high energy ions (HZEs) such as Fe, Si, and O. HZE exposure is a major risk factor for astronauts during deep-space travel due to the possibility of HZE-induced cancer. A systems biology integrated omics appr...

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Veröffentlicht in:	International journal of molecular sciences 2021-10, Vol.22 (21), p.11806
Hauptverfasser:	Barnette, Brooke L, Yu, Yongjia, Ullrich, Robert L, Emmett, Mark R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astronauts Biosynthesis Cesium 137 Cesium isotopes Cosmic radiation Cosmic Radiation - adverse effects Cosmic rays Datasets Deep space Dose-Response Relationship, Radiation Electron transport chain Electron Transport Complex I - metabolism Energy charge Exposure Galactic cosmic rays Gamma rays Gamma Rays - adverse effects Helium High energy astronomy INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY integrated omics Iron isotopes Irradiation Lipids Liver Liver - enzymology Liver - pathology Male Mars Mice Mitochondria Mitochondria, Liver - enzymology Mitochondria, Liver - pathology mitochondrial dysfunction NADH-ubiquinone oxidoreductase Oxidation Oxidative stress Post-irradiation Proteins Proteomics Radiation Radiation Injuries, Experimental - enzymology Radiation Injuries, Experimental - pathology Risk analysis Risk factors Space Flight space radiation systems biology Transcriptomics Travel
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