Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application...
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| Veröffentlicht in: | International journal of molecular sciences 2021-10, Vol.22 (21), p.11525 |
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| creator | Tsakanova, Gohar Babayan, Nelly Karalova, Elena Hakobyan, Lina Abroyan, Liana Avetisyan, Aida Avagyan, Hranush Hakobyan, Sona Poghosyan, Arpine Baghdasaryan, Bagrat Arakelova, Elina Ayvazyan, Violetta Matevosyan, Lusine Navasardyan, Arpine Davtyan, Hakob Apresyan, Lilit Yeremyan, Arsham Aroutiounian, Rouben Osipov, Andreyan N Grigoryan, Bagrat Karalyan, Zaven |
| description | The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application of UPEBs in radiation biology and medicine, the aim of this study was to reveal the changes in immune system in response to low-energy laser-driven UPEB whole-body irradiation in rodents. Forty male albino
rats were exposed to laser-driven UPEB irradiation, after which different immunological parameters were studied on the 1st, 3rd, 7th, 14th, and 28th day after irradiation. According to the results, this type of irradiation induces alterations in the rat immune system, particularly by increasing the production of pro- and anti-inflammatory cytokines and elevating the DNA damage rate. Moreover, such an immune response reaches its maximal levels on the third day after laser-driven UPEB whole-body irradiation, showing partial recovery on subsequent days with a total recovery on the 28th day. The results of this study provide valuable insight into the effect of laser-driven UPEB whole-body irradiation on the immune system of the animals and support further animal experiments on the role of this novel type of irradiation. |
| doi_str_mv | 10.3390/ijms222111525 |
| format | Article |
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rats were exposed to laser-driven UPEB irradiation, after which different immunological parameters were studied on the 1st, 3rd, 7th, 14th, and 28th day after irradiation. According to the results, this type of irradiation induces alterations in the rat immune system, particularly by increasing the production of pro- and anti-inflammatory cytokines and elevating the DNA damage rate. Moreover, such an immune response reaches its maximal levels on the third day after laser-driven UPEB whole-body irradiation, showing partial recovery on subsequent days with a total recovery on the 28th day. The results of this study provide valuable insight into the effect of laser-driven UPEB whole-body irradiation on the immune system of the animals and support further animal experiments on the role of this novel type of irradiation.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms222111525</identifier><identifier>PMID: 34768958</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animal research ; Animals ; Blood ; Bone marrow ; Bone Marrow - immunology ; Bone Marrow - pathology ; Bone Marrow - radiation effects ; Cancer therapies ; Cytokines ; Cytokines - biosynthesis ; DNA Damage ; DNA Repair - radiation effects ; Drug dosages ; Electron beams ; Electron irradiation ; Electrons - adverse effects ; Immune response ; Immune system ; Immunity - radiation effects ; Immunology ; Inflammation ; Lasers ; Lasers - adverse effects ; Leukocytes - immunology ; Leukocytes - pathology ; Leukocytes - radiation effects ; Linear accelerators ; Lymphocytes ; Male ; Neutrophils ; Particle Accelerators ; Population ; Radiation therapy ; Radiobiology ; Rats ; Rats, Wistar ; Tumors ; Whole-Body Irradiation - adverse effects</subject><ispartof>International journal of molecular sciences, 2021-10, Vol.22 (21), p.11525</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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rats were exposed to laser-driven UPEB irradiation, after which different immunological parameters were studied on the 1st, 3rd, 7th, 14th, and 28th day after irradiation. According to the results, this type of irradiation induces alterations in the rat immune system, particularly by increasing the production of pro- and anti-inflammatory cytokines and elevating the DNA damage rate. Moreover, such an immune response reaches its maximal levels on the third day after laser-driven UPEB whole-body irradiation, showing partial recovery on subsequent days with a total recovery on the 28th day. 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| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2021-10, Vol.22 (21), p.11525 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8584044 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animal research Animals Blood Bone marrow Bone Marrow - immunology Bone Marrow - pathology Bone Marrow - radiation effects Cancer therapies Cytokines Cytokines - biosynthesis DNA Damage DNA Repair - radiation effects Drug dosages Electron beams Electron irradiation Electrons - adverse effects Immune response Immune system Immunity - radiation effects Immunology Inflammation Lasers Lasers - adverse effects Leukocytes - immunology Leukocytes - pathology Leukocytes - radiation effects Linear accelerators Lymphocytes Male Neutrophils Particle Accelerators Population Radiation therapy Radiobiology Rats Rats, Wistar Tumors Whole-Body Irradiation - adverse effects |
| title | Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T00%3A39%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low-Energy%20Laser-Driven%20Ultrashort%20Pulsed%20Electron%20Beam%20Irradiation-Induced%20Immune%20Response%20in%20Rats&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Tsakanova,%20Gohar&rft.date=2021-10-26&rft.volume=22&rft.issue=21&rft.spage=11525&rft.pages=11525-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms222111525&rft_dat=%3Cproquest_pubme%3E2596039022%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2596039022&rft_id=info:pmid/34768958&rfr_iscdi=true |