Histone Modification in NSCLC: Molecular Mechanisms and Therapeutic Targets

Lung cancer is the leading cause of cancer mortality in both genders, with non-small cell lung cancer (NSCLC) accounting for about 85% of all lung cancers. At the time of diagnosis, the tumour is usually locally advanced or metastatic, shaping a poor disease outcome. NSCLC includes adenocarcinoma, s...

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Veröffentlicht in:	International journal of molecular sciences 2021-10, Vol.22 (21), p.11701
Hauptverfasser:	Bajbouj, Khuloud, Al-Ali, Abeer, Ramakrishnan, Rakhee K, Saber-Ayad, Maha, Hamid, Qutayba
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adenocarcinoma Animals Apoptosis Cancer therapies Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - therapy Cell cycle Clinical trials Deacetylation DNA methylation Drug resistance Enzymes Epigenesis, Genetic Epigenetics Gene expression Genetic diversity Growth factors Heterogeneity Histone Code Histone deacetylase Histones Histones - metabolism Humans Immunotherapy Lung cancer Lung carcinoma Metastases Methylation MicroRNAs Molecular modelling Molecular Targeted Therapy Mutation Non-small cell lung carcinoma Pattern recognition Phosphorylation Pollutants Proteins Review Smoking Squamous cell carcinoma Therapeutic applications Therapeutic targets Transcription Transcription factors Tumors
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