A Phase Ib Study of Sotrastaurin, a PKC Inhibitor, and Alpelisib, a PI3Kα Inhibitor, in Patients with Metastatic Uveal Melanoma

Uveal melanoma (UM) is a rare subset of melanoma characterized by the presence of early initiating GNAQ/11 mutations, with downstream activation of the PKC, MAPK, and PI3Kα pathways. Activity has been observed with the PKC inhibitors sotrastaurin (AEB071) and darovasertib (IDE196) in patients with U...

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Veröffentlicht in:	Cancers 2021-11, Vol.13 (21), p.5504
Hauptverfasser:	Shoushtari, Alexander N, Khan, Shaheer, Komatsubara, Kimberly, Feun, Lynn, Acquavella, Nicolas, Singh-Kandah, Shahnaz, Negri, Tiffany, Nesson, Alexandra, Abbate, Kelly, Cremers, Serge, Musi, Elgilda, Ambrosini, Grazia, Lee, Shing, Schwartz, Gary K, Carvajal, Richard D
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adverse events Biopsy Enrollments Gene expression Immunosuppression Immunosuppressive agents Kinases MAP kinase Melanoma Metastases Metastasis Mutation Patients Pharmacodynamics Pharmacokinetics Plasma Protein kinase C Proteins Response rates
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