Mapping Tumor Spheroid Mechanics in Dependence of 3D Microenvironment Stiffness and Degradability by Brillouin Microscopy

Altered biophysical properties of cancer cells and of their microenvironment contribute to cancer progression. While the relationship between microenvironmental stiffness and cancer cell mechanical properties and responses has been previously studied using two-dimensional (2D) systems, much less is...

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Veröffentlicht in:	Cancers 2021-11, Vol.13 (21), p.5549
Hauptverfasser:	Mahajan, Vaibhav, Beck, Timon, Gregorczyk, Paulina, Ruland, André, Alberti, Simon, Guck, Jochen, Werner, Carsten, Schlüßler, Raimund, Taubenberger, Anna Verena
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cell culture Degradability Genotype & phenotype Heparin Hydrogels Invasiveness Matrix metalloproteinase Mechanical properties Mechanics Metalloproteinase Metastasis Microenvironments Microscopy Pancreatic cancer Penicillin Polyethylene glycol Prostate Prostate cancer Spatial variations Spheroids Tumor cell lines Tumors
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