Memantine Modulates Oxidative Stress in the Rat Brain following Experimental Autoimmune Encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) is an animal model most commonly used in research on the pathomechanisms of multiple sclerosis (MS). The inflammatory processes, glutamate excitotoxicity, and oxidative stress have been proposed as determinants accompanying demyelination and neuronal d...

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Veröffentlicht in:	International journal of molecular sciences 2021-10, Vol.22 (21), p.11330
Hauptverfasser:	Dąbrowska-Bouta, Beata, Strużyńska, Lidia, Sidoryk-Węgrzynowicz, Marta, Sulkowski, Grzegorz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Body Weight - drug effects Brain - drug effects Brain - metabolism Cytokines Degeneration Demyelination Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - drug therapy Enzymes Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Excitotoxicity Experimental allergic encephalomyelitis Experiments Female Free radicals Glutamic acid receptors Glutamic acid receptors (ionotropic) Inflammation Kinases Lipid peroxidation Lipids Malondialdehyde Memantine Memantine - pharmacology Memantine - therapeutic use Multiple sclerosis N-Methyl-D-aspartic acid receptors Nervous System Diseases - drug therapy Neurodegeneration Neurological diseases Neuromodulation Oxidative stress Oxidative Stress - drug effects Paralysis Physical activity Physiology Proteins Rats Rats, Inbred Lew Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism
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