Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells

Tobacco smoking is the top risk factor for lung cancer development. Nicotine in cigarettes can induce addiction, and its derivatives become potent carcinogens after metabolic activation and activate oncogenic signaling in lung epithelial cells through their expressed nicotinic acetylcholine receptor...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancers 2021-10, Vol.13 (21), p.5345
Hauptverfasser:	Kwok, Hoi-Hin, Gao, Boning, Chan, Koon-Ho, Ip, Mary Sau-Man, Minna, John Dorrance, Lam, David Chi-Leung
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Addictions Antibodies Biopsy Biotechnology Bronchoscopy Cancer immunotherapy Cancer therapies Carcinogenesis Carcinogens Cell culture Cigarette smoke Cigarettes Epithelial cells Gene expression Immunotherapy Ligands Lung cancer Metabolic activation Metabolic rate Microenvironments Mutation Nicotine Pathogenesis PD-L1 protein Phosphorylation Proteins Risk factors Signal transduction siRNA Smoking Stat3 protein Tobacco Tobacco smoking Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!