CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice

Platelets play an essential role in atherosclerosis, but the underlying mechanisms remain to be addressed. This study is to investigate the role of platelets in d-flow induced vascular inflammation and the underlying mechanism. We established a disturbed blood flow (d-flow) model by partial carotid...

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Veröffentlicht in:	Theranostics 2021-01, Vol.11 (20), p.9791-9804
Hauptverfasser:	Tang, Chaojun, Wang, Lei, Sheng, Yulan, Zheng, Zhong, Xie, Zhanli, Wu, Fan, You, Tao, Ren, Lijie, Xia, Lijun, Ruan, Changgeng, Zhu, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Atherosclerosis Atherosclerosis - etiology Atherosclerosis - genetics Atherosclerosis - metabolism Blood Circulation Blood platelets Blood Platelets - metabolism Carotid arteries Coronary vessels Endothelium Female Inflammation Lectins, C-Type - genetics Lectins, C-Type - metabolism Leukocytes - metabolism Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Monocytes - metabolism Neutrophils Pathogenesis Plaque, Atherosclerotic - metabolism Research Paper Veins & arteries
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