HIF‐1α promotes the proliferation and migration of pulmonary arterial smooth muscle cells via activation of Cx43

The proliferation of pulmonary artery smooth muscle cells (PASMCs) is an important cause of pulmonary vascular remodelling in hypoxia‐induced pulmonary hypertension (HPH). However, its underlying mechanism has not been well elucidated. Connexin 43 (Cx43) plays crucial roles in vascular smooth muscle...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2021-11, Vol.25 (22), p.10663-10673
Hauptverfasser:	Han, Xiao‐Jian, Zhang, Wei‐Fang, Wang, Qin, Li, Min, Zhang, Chun‐Bo, Yang, Zhang‐Jian, Tan, Ren‐Jie, Gan, Li‐Jun, Zhang, Le‐Ling, Lan, Xue‐Mei, Zhang, Fang‐Lin, Hong, Tao, Jiang, Li‐Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Animals Cardiovascular diseases Cell activation Cell growth Cell Proliferation Cells, Cultured Chromatin Connexin 43 Connexin 43 - agonists Connexin 43 - genetics Connexin 43 - metabolism Echinomycin Experiments Hypoxia Hypoxia - genetics Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism hypoxia‐induced pulmonary hypertension Immunohistochemistry Immunoprecipitation migration Models, Biological Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - metabolism Original Phosphorylation proliferation Promoter Regions, Genetic Protein Binding Proteins Pulmonary arteries Pulmonary artery Pulmonary Artery - cytology Pulmonary Artery - metabolism pulmonary artery smooth muscle cells Pulmonary hypertension Rats Smooth muscle Statistical analysis Veins & arteries Wound healing
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