Variants Ala307Ala and Ser680Ser of 307 and 680 FSHr polymorphisms negatively influence on assisted reproductive techniques outcome and determine high probability of non-pregnancy in Caucasian patients
Purpose To determine the influence of different genotypes of Ala307Thr and Asn680Ser FSHr polymorphisms on controlled ovarian stimulation (COS) outcome and pregnancy. Methods This study collected blood and physiological and clinical parameters of 517 Caucasian patients (Statistical power ≥ 80%) that...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2021-10, Vol.38 (10), p.2769-2779 |
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| creator | Monge-Ochoa, Belén Montoro, Luis Gil-Arribas, Elisa Montoya, Julio Ruiz-Pesini, Eduardo López-Pérez, Manuel J. de Castro, Francisco Díez-Sánchez, Carmen |
| description | Purpose
To determine the influence of different genotypes of Ala307Thr and Asn680Ser
FSHr
polymorphisms on controlled ovarian stimulation (COS) outcome and pregnancy.
Methods
This study collected blood and physiological and clinical parameters of 517 Caucasian patients (Statistical power ≥ 80%) that underwent COS treatment. Genotypes of Ala307Thr and Asn680Ser polymorphisms were determined using PCR amplification followed by Bsu36I and BsrI digestion, respectively.
Results
Ala307Ala and Ser680Ser genotypes associated to worse parameters of COS outcome (preovulatory follicles
P
= 0.05, in both), justifying their lower pregnancy rate than Non-Ala307Ala,
P
= 0.01 and Non-Ser680Ser,
P
= 0.004, respectively or together, (
P
= 0.003). Within the Non-Ala307Ala group, Thr307Thr genotype showed higher number of fertilized oocytes (
P
= 0.04) and embryos (
P
= 0.01) than Non-Thr307Thr, but no influence on pregnancy rate. Ala307Ala and Ser680Ser patients doubled probability of non-pregnancy than Non-Ala307Ala (odds ratio = 2.0) and Non-Ser680Ser (odds ratio = 2.11), respectively. Ala307Ala and Ser680Ser genotypes tend to appear together (
P
< 0.0001), which increases the probability of non-pregnancy.
Conclusions
Ala307Ala and Ser680Ser genotypes of 307 and 680 FSHr polymorphisms associate to worse COS outcome than its respective Non-Ala307Ala and Non-Ser680Ser. Within the Non-Ala307Ala genotypes, Thr307Thr, although shows higher Fertilized Oocytes and Embryos, do not influence on pregnancy rate. Ala307Ala and Ser680Ser genotypes double the probability of Non-Pregnancy than their respective Non-Ala307Ala and Non-Ser680Ser genotypes. Furthermore, the strong tendency of these genotypes to appear together worsens the probability of pregnancy in these patients. |
| doi_str_mv | 10.1007/s10815-021-02276-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8581085</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2595787052</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-4b68486346b1b2cdba39bc567224a61aabf2f2ee9ec8629a03ded8ec29062cba3</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhiMEoh_wBzggS1y4BCZ24jgXpGpFW6RKHApcLceZ7LpK7GAnlfYn8q-Y7JbyceAQxxo_886M_WbZqwLeFQD1-1SAKqoceEEfr2UOT7LToqpFXgsBT2kPlcqhlOokO0vpDgAaxcXz7ESUopQA_DT78c1EZ_yc2MVgBNS0MuM7dotRKqCVhZ5R_BCkCLu8vY5sCsN-DHHauTQm5nFrZnePw5453w8LeosseGZScmnGjkWcYugWu0JsRrvz7vuCiYVltmHEg3aHM8bReWQ7t90xSmhN6wY379cOfPD5FHHrjbdrFbYxizWJOmcT1UYa4EX2rDdDwpcP__Ps6-XHL5vr_Obz1afNxU1uy7qc87KVqlSS5m-LltuuNaJpbSVrzksjC2PanvccsUGrJG8MiA47hZY3ILkl-jz7cNSdlnbEzlLtaAY9RTeauNfBOP33iXc7vQ33WlWKHqwigbcPAjGs1zDr0SWLw2A8hiVpXlUKGiGVIvTNP-hdWKKn8YhqqlrVUHGi-JGyMaQUsX9spgC9OkUfnaLJKfrgFA2U9PrPMR5TflmDAHEEEh35Lcbftf8j-xNPxc2Z</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2595787052</pqid></control><display><type>article</type><title>Variants Ala307Ala and Ser680Ser of 307 and 680 FSHr polymorphisms negatively influence on assisted reproductive techniques outcome and determine high probability of non-pregnancy in Caucasian patients</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Monge-Ochoa, Belén ; Montoro, Luis ; Gil-Arribas, Elisa ; Montoya, Julio ; Ruiz-Pesini, Eduardo ; López-Pérez, Manuel J. ; de Castro, Francisco ; Díez-Sánchez, Carmen</creator><creatorcontrib>Monge-Ochoa, Belén ; Montoro, Luis ; Gil-Arribas, Elisa ; Montoya, Julio ; Ruiz-Pesini, Eduardo ; López-Pérez, Manuel J. ; de Castro, Francisco ; Díez-Sánchez, Carmen</creatorcontrib><description>Purpose
To determine the influence of different genotypes of Ala307Thr and Asn680Ser
FSHr
polymorphisms on controlled ovarian stimulation (COS) outcome and pregnancy.
Methods
This study collected blood and physiological and clinical parameters of 517 Caucasian patients (Statistical power ≥ 80%) that underwent COS treatment. Genotypes of Ala307Thr and Asn680Ser polymorphisms were determined using PCR amplification followed by Bsu36I and BsrI digestion, respectively.
Results
Ala307Ala and Ser680Ser genotypes associated to worse parameters of COS outcome (preovulatory follicles
P
= 0.05, in both), justifying their lower pregnancy rate than Non-Ala307Ala,
P
= 0.01 and Non-Ser680Ser,
P
= 0.004, respectively or together, (
P
= 0.003). Within the Non-Ala307Ala group, Thr307Thr genotype showed higher number of fertilized oocytes (
P
= 0.04) and embryos (
P
= 0.01) than Non-Thr307Thr, but no influence on pregnancy rate. Ala307Ala and Ser680Ser patients doubled probability of non-pregnancy than Non-Ala307Ala (odds ratio = 2.0) and Non-Ser680Ser (odds ratio = 2.11), respectively. Ala307Ala and Ser680Ser genotypes tend to appear together (
P
< 0.0001), which increases the probability of non-pregnancy.
Conclusions
Ala307Ala and Ser680Ser genotypes of 307 and 680 FSHr polymorphisms associate to worse COS outcome than its respective Non-Ala307Ala and Non-Ser680Ser. Within the Non-Ala307Ala genotypes, Thr307Thr, although shows higher Fertilized Oocytes and Embryos, do not influence on pregnancy rate. Ala307Ala and Ser680Ser genotypes double the probability of Non-Pregnancy than their respective Non-Ala307Ala and Non-Ser680Ser genotypes. Furthermore, the strong tendency of these genotypes to appear together worsens the probability of pregnancy in these patients.</description><identifier>ISSN: 1058-0468</identifier><identifier>ISSN: 1573-7330</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-021-02276-0</identifier><identifier>PMID: 34346002</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Embryos ; Female ; Follicles ; Genetics ; Gynecology ; Human Genetics ; Humans ; Infertility, Female - genetics ; Infertility, Female - pathology ; Infertility, Female - therapy ; Medicine ; Medicine & Public Health ; Oocytes ; Ovulation Induction - statistics & numerical data ; Patients ; Polymorphism, Single Nucleotide ; Pregnancy ; Pregnancy Rate ; Receptors, FSH - genetics ; Reproduction ; Reproductive Medicine ; Reproductive Techniques, Assisted - adverse effects</subject><ispartof>Journal of assisted reproduction and genetics, 2021-10, Vol.38 (10), p.2769-2779</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-4b68486346b1b2cdba39bc567224a61aabf2f2ee9ec8629a03ded8ec29062cba3</citedby><cites>FETCH-LOGICAL-c474t-4b68486346b1b2cdba39bc567224a61aabf2f2ee9ec8629a03ded8ec29062cba3</cites><orcidid>0000-0002-1299-3033</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581085/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581085/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34346002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monge-Ochoa, Belén</creatorcontrib><creatorcontrib>Montoro, Luis</creatorcontrib><creatorcontrib>Gil-Arribas, Elisa</creatorcontrib><creatorcontrib>Montoya, Julio</creatorcontrib><creatorcontrib>Ruiz-Pesini, Eduardo</creatorcontrib><creatorcontrib>López-Pérez, Manuel J.</creatorcontrib><creatorcontrib>de Castro, Francisco</creatorcontrib><creatorcontrib>Díez-Sánchez, Carmen</creatorcontrib><title>Variants Ala307Ala and Ser680Ser of 307 and 680 FSHr polymorphisms negatively influence on assisted reproductive techniques outcome and determine high probability of non-pregnancy in Caucasian patients</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
To determine the influence of different genotypes of Ala307Thr and Asn680Ser
FSHr
polymorphisms on controlled ovarian stimulation (COS) outcome and pregnancy.
Methods
This study collected blood and physiological and clinical parameters of 517 Caucasian patients (Statistical power ≥ 80%) that underwent COS treatment. Genotypes of Ala307Thr and Asn680Ser polymorphisms were determined using PCR amplification followed by Bsu36I and BsrI digestion, respectively.
Results
Ala307Ala and Ser680Ser genotypes associated to worse parameters of COS outcome (preovulatory follicles
P
= 0.05, in both), justifying their lower pregnancy rate than Non-Ala307Ala,
P
= 0.01 and Non-Ser680Ser,
P
= 0.004, respectively or together, (
P
= 0.003). Within the Non-Ala307Ala group, Thr307Thr genotype showed higher number of fertilized oocytes (
P
= 0.04) and embryos (
P
= 0.01) than Non-Thr307Thr, but no influence on pregnancy rate. Ala307Ala and Ser680Ser patients doubled probability of non-pregnancy than Non-Ala307Ala (odds ratio = 2.0) and Non-Ser680Ser (odds ratio = 2.11), respectively. Ala307Ala and Ser680Ser genotypes tend to appear together (
P
< 0.0001), which increases the probability of non-pregnancy.
Conclusions
Ala307Ala and Ser680Ser genotypes of 307 and 680 FSHr polymorphisms associate to worse COS outcome than its respective Non-Ala307Ala and Non-Ser680Ser. Within the Non-Ala307Ala genotypes, Thr307Thr, although shows higher Fertilized Oocytes and Embryos, do not influence on pregnancy rate. Ala307Ala and Ser680Ser genotypes double the probability of Non-Pregnancy than their respective Non-Ala307Ala and Non-Ser680Ser genotypes. Furthermore, the strong tendency of these genotypes to appear together worsens the probability of pregnancy in these patients.</description><subject>Adult</subject><subject>Embryos</subject><subject>Female</subject><subject>Follicles</subject><subject>Genetics</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Infertility, Female - genetics</subject><subject>Infertility, Female - pathology</subject><subject>Infertility, Female - therapy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oocytes</subject><subject>Ovulation Induction - statistics & numerical data</subject><subject>Patients</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Receptors, FSH - genetics</subject><subject>Reproduction</subject><subject>Reproductive Medicine</subject><subject>Reproductive Techniques, Assisted - adverse effects</subject><issn>1058-0468</issn><issn>1573-7330</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kk1v1DAQhiMEoh_wBzggS1y4BCZ24jgXpGpFW6RKHApcLceZ7LpK7GAnlfYn8q-Y7JbyceAQxxo_886M_WbZqwLeFQD1-1SAKqoceEEfr2UOT7LToqpFXgsBT2kPlcqhlOokO0vpDgAaxcXz7ESUopQA_DT78c1EZ_yc2MVgBNS0MuM7dotRKqCVhZ5R_BCkCLu8vY5sCsN-DHHauTQm5nFrZnePw5453w8LeosseGZScmnGjkWcYugWu0JsRrvz7vuCiYVltmHEg3aHM8bReWQ7t90xSmhN6wY379cOfPD5FHHrjbdrFbYxizWJOmcT1UYa4EX2rDdDwpcP__Ps6-XHL5vr_Obz1afNxU1uy7qc87KVqlSS5m-LltuuNaJpbSVrzksjC2PanvccsUGrJG8MiA47hZY3ILkl-jz7cNSdlnbEzlLtaAY9RTeauNfBOP33iXc7vQ33WlWKHqwigbcPAjGs1zDr0SWLw2A8hiVpXlUKGiGVIvTNP-hdWKKn8YhqqlrVUHGi-JGyMaQUsX9spgC9OkUfnaLJKfrgFA2U9PrPMR5TflmDAHEEEh35Lcbftf8j-xNPxc2Z</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Monge-Ochoa, Belén</creator><creator>Montoro, Luis</creator><creator>Gil-Arribas, Elisa</creator><creator>Montoya, Julio</creator><creator>Ruiz-Pesini, Eduardo</creator><creator>López-Pérez, Manuel J.</creator><creator>de Castro, Francisco</creator><creator>Díez-Sánchez, Carmen</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1299-3033</orcidid></search><sort><creationdate>20211001</creationdate><title>Variants Ala307Ala and Ser680Ser of 307 and 680 FSHr polymorphisms negatively influence on assisted reproductive techniques outcome and determine high probability of non-pregnancy in Caucasian patients</title><author>Monge-Ochoa, Belén ; Montoro, Luis ; Gil-Arribas, Elisa ; Montoya, Julio ; Ruiz-Pesini, Eduardo ; López-Pérez, Manuel J. ; de Castro, Francisco ; Díez-Sánchez, Carmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-4b68486346b1b2cdba39bc567224a61aabf2f2ee9ec8629a03ded8ec29062cba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Embryos</topic><topic>Female</topic><topic>Follicles</topic><topic>Genetics</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Infertility, Female - genetics</topic><topic>Infertility, Female - pathology</topic><topic>Infertility, Female - therapy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oocytes</topic><topic>Ovulation Induction - statistics & numerical data</topic><topic>Patients</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Receptors, FSH - genetics</topic><topic>Reproduction</topic><topic>Reproductive Medicine</topic><topic>Reproductive Techniques, Assisted - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monge-Ochoa, Belén</creatorcontrib><creatorcontrib>Montoro, Luis</creatorcontrib><creatorcontrib>Gil-Arribas, Elisa</creatorcontrib><creatorcontrib>Montoya, Julio</creatorcontrib><creatorcontrib>Ruiz-Pesini, Eduardo</creatorcontrib><creatorcontrib>López-Pérez, Manuel J.</creatorcontrib><creatorcontrib>de Castro, Francisco</creatorcontrib><creatorcontrib>Díez-Sánchez, Carmen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monge-Ochoa, Belén</au><au>Montoro, Luis</au><au>Gil-Arribas, Elisa</au><au>Montoya, Julio</au><au>Ruiz-Pesini, Eduardo</au><au>López-Pérez, Manuel J.</au><au>de Castro, Francisco</au><au>Díez-Sánchez, Carmen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variants Ala307Ala and Ser680Ser of 307 and 680 FSHr polymorphisms negatively influence on assisted reproductive techniques outcome and determine high probability of non-pregnancy in Caucasian patients</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>38</volume><issue>10</issue><spage>2769</spage><epage>2779</epage><pages>2769-2779</pages><issn>1058-0468</issn><issn>1573-7330</issn><eissn>1573-7330</eissn><abstract>Purpose
To determine the influence of different genotypes of Ala307Thr and Asn680Ser
FSHr
polymorphisms on controlled ovarian stimulation (COS) outcome and pregnancy.
Methods
This study collected blood and physiological and clinical parameters of 517 Caucasian patients (Statistical power ≥ 80%) that underwent COS treatment. Genotypes of Ala307Thr and Asn680Ser polymorphisms were determined using PCR amplification followed by Bsu36I and BsrI digestion, respectively.
Results
Ala307Ala and Ser680Ser genotypes associated to worse parameters of COS outcome (preovulatory follicles
P
= 0.05, in both), justifying their lower pregnancy rate than Non-Ala307Ala,
P
= 0.01 and Non-Ser680Ser,
P
= 0.004, respectively or together, (
P
= 0.003). Within the Non-Ala307Ala group, Thr307Thr genotype showed higher number of fertilized oocytes (
P
= 0.04) and embryos (
P
= 0.01) than Non-Thr307Thr, but no influence on pregnancy rate. Ala307Ala and Ser680Ser patients doubled probability of non-pregnancy than Non-Ala307Ala (odds ratio = 2.0) and Non-Ser680Ser (odds ratio = 2.11), respectively. Ala307Ala and Ser680Ser genotypes tend to appear together (
P
< 0.0001), which increases the probability of non-pregnancy.
Conclusions
Ala307Ala and Ser680Ser genotypes of 307 and 680 FSHr polymorphisms associate to worse COS outcome than its respective Non-Ala307Ala and Non-Ser680Ser. Within the Non-Ala307Ala genotypes, Thr307Thr, although shows higher Fertilized Oocytes and Embryos, do not influence on pregnancy rate. Ala307Ala and Ser680Ser genotypes double the probability of Non-Pregnancy than their respective Non-Ala307Ala and Non-Ser680Ser genotypes. Furthermore, the strong tendency of these genotypes to appear together worsens the probability of pregnancy in these patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34346002</pmid><doi>10.1007/s10815-021-02276-0</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1299-3033</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 2021-10, Vol.38 (10), p.2769-2779 |
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| source | MEDLINE; SpringerLink Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Embryos Female Follicles Genetics Gynecology Human Genetics Humans Infertility, Female - genetics Infertility, Female - pathology Infertility, Female - therapy Medicine Medicine & Public Health Oocytes Ovulation Induction - statistics & numerical data Patients Polymorphism, Single Nucleotide Pregnancy Pregnancy Rate Receptors, FSH - genetics Reproduction Reproductive Medicine Reproductive Techniques, Assisted - adverse effects |
| title | Variants Ala307Ala and Ser680Ser of 307 and 680 FSHr polymorphisms negatively influence on assisted reproductive techniques outcome and determine high probability of non-pregnancy in Caucasian patients |
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