The cellular architecture of the antimicrobial response network in human leprosy granulomas

Granulomas are complex cellular structures composed predominantly of macrophages and lymphocytes that function to contain and kill invading pathogens. Here, we investigated the single-cell phenotypes associated with antimicrobial responses in human leprosy granulomas by applying single-cell and spat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2021-07, Vol.22 (7), p.839-850
Hauptverfasser:	Ma, Feiyang, Hughes, Travis K., Teles, Rosane M. B., Andrade, Priscila R., de Andrade Silva, Bruno J., Plazyo, Olesya, Tsoi, Lam C., Do, Tran, Wadsworth, Marc H., Oulee, Aislyn, Ochoa, Maria Teresa, Sarno, Euzenir N., Iruela-Arispe, M. Luisa, Klechevsky, Eynav, Bryson, Bryan, Shalek, Alex K., Bloom, Barry R., Gudjonsson, Johann E., Pellegrini, Matteo, Modlin, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/514/1949 631/250/2499 Adolescent Adult Aged Antimicrobial agents Biomedical and Life Sciences Biomedicine Biopsy Cell interaction Development and progression Drug therapy Female Fibroblasts Fibroblasts - immunology Fibroblasts - microbiology Fibroblasts - pathology Gene expression Gene Expression Profiling Gene mapping Genetic aspects Granuloma Granulomas Host-Pathogen Interactions Humans IL-1β Immune response Immunological research Immunology Infectious Diseases Keratinocytes Keratinocytes - immunology Keratinocytes - microbiology Keratinocytes - pathology Leprosy Leprosy, Lepromatous - genetics Leprosy, Lepromatous - immunology Leprosy, Lepromatous - microbiology Leprosy, Lepromatous - pathology Leprosy, Tuberculoid - genetics Leprosy, Tuberculoid - immunology Leprosy, Tuberculoid - microbiology Leprosy, Tuberculoid - pathology Lesions Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Macrophages - microbiology Macrophages - pathology Male Middle Aged Mycobacterium leprae - immunology Mycobacterium leprae - pathogenicity Phenotypes RNA-Seq Single-Cell Analysis Skin - immunology Skin - microbiology Skin - pathology Skin diseases Skin lesions Spatial analysis T-Lymphocytes - immunology T-Lymphocytes - microbiology T-Lymphocytes - pathology Transcriptome γ-Interferon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!