Extracellular Vesicle-Mediated Secretion of HLA-E by Trophoblasts Maintains Pregnancy by Regulating the Metabolism of Decidual NK Cells

Extracellular vesicles derived from trophoblasts (T-EVs) play an important role in pregnancy, but the mechanism is not entirely clear. In this study, we found that HLA-E, which is mostly confined to the cytoplasm of trophoblast cells, was secreted by T-EVs. The level of HLA-E in T-EVs from unexplain...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of biological sciences 2021-01, Vol.17 (15), p.4377-4395
Hauptverfasser:	Jiang, Lingling, Fei, Haiyi, Jin, Xiaoying, Liu, Xiu, Yang, Cuiyu, Li, Chao, Chen, Jianmin, Yang, Anran, Zhu, Jiajuan, Wang, Huihong, Fei, Xiaoyang, Zhang, Songying
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal models Animals Cell Line Cytoplasm Cytotoxicity Decidua Decidua - cytology Embryos Extracellular Vesicles - metabolism Female Flow cytometry Gestational age Glycolysis Helper cells Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism HLA-E Antigens Humans Immune system Interferon-gamma - genetics Interferon-gamma - metabolism Karyotypes Killer Cells, Natural - physiology Kinases Laboratory animals Ligands Lymphocytes T Metabolism Mice Mice, Nude Miscarriage Oxidative phosphorylation Phosphorylation Placenta - cytology Pregnancy Research Paper Secretion Tissue Culture Techniques Trophoblasts Trophoblasts - physiology Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism γ-Interferon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!