Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3 + NK Cell Subset with a Bcl11b-Regulated T Cell Signature

Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers, we find that prior HCMV infection promotes NK cells with a T cell-like gene profile,...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of immunology (1950) 2021-11, Vol.207 (10), p.2534-2544
Hauptverfasser:	Wu, Zeguang, Lau, Colleen M, Sottile, Rosa, Le Luduec, Jean-Benoît, Panjwani, M Kazim, Conaty, Peter M, Srpan, Katja, Laib Sampaio, Kerstin, Mertens, Thomas, Adler, Stuart P, Hill, Ann B, Barker, Juliet N, Cheung, Nai-Kong V, Sun, Joseph C, Hsu, Katharine C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody-Dependent Cell Cytotoxicity - immunology CD3 Complex - immunology Cytomegalovirus Infections - immunology Humans Innate Immunity and Inflammation Killer Cells, Natural - immunology Lymphocyte Subsets - immunology Mice Mice, Transgenic Repressor Proteins - immunology Transcriptome Tumor Suppressor Proteins - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!