Methicillin-resistant Staphylococcus aureus of the clonal lineage ST5-SCCmecII-t2460 was associated with high mortality in a Wuhan hospital
Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen that can cause serious infectious diseases. An emerging MRSA strain, ST5-SCC mec II spa -type-t2460 (SMRSA), has spread rapidly since its recent emergence in China, but little information is available about this lineag...
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| Veröffentlicht in: | Brazilian journal of microbiology 2021-12, Vol.52 (4), p.1929-1936 |
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| creator | Li, Xuehan Zhang, Jing Zhang, Yifan Zhou, Junying Li, Xinwei Feng, Ruo Li, Yirong |
| description | Methicillin-resistant
Staphylococcus aureus
(MRSA) is an important human pathogen that can cause serious infectious diseases. An emerging MRSA strain, ST5-SCC
mec
II
spa
-type-t2460 (SMRSA), has spread rapidly since its recent emergence in China, but little information is available about this lineage. In this study, 91 MRSA isolates were collected from patients treated in the Zhongnan Hospital, Wuhan University, from 2018 to 2019, and investigated for their molecular characteristics, antibiotic resistance profiles, and clinical characteristics. The predominant lineage, SMRSA, accounted for 37.4% (34/91) of the isolates, followed by ST239-SCC
mec
III-t030 (19.8%, 18/91) and ST59-SCC
mec
IV-t437 (8.8%, 8/91). In contrast to the latter two non-SMRSA (nSMRSA) lineages, which are among the main MRSA found in Chinese settings, SMRSA exhibited small colony variant (SCV) phenotype and had extremely high resistance rates to erythromycin (100.0%), clindamycin (100.0%), levofloxacin (100.0%), tetracycline (97.1%), moxifloxacin (97.1%), and ciprofloxacin (100%), but was more susceptible to rifampicin (resistance rate 3%). The levels of white blood cells (WBC) and procalcitonin (PCT) and the 30-day mortality in patients infected with SMRSA were (12.54 ± 6.61) × 10
9
/L, 0.66 ng/mL, and 52.9%, respectively, which were much higher than those in patients infected with nSMRSA. In addition, patients infected with SMRSA were more frequently admitted to the intensive care unit (ICU) and submitted to invasive procedures than those infected with nSMRSA. In conclusion, SMRSA showed SCV phenotype and exhibited multiple antibiotic-resistance profiles. In this study, SMRSA was associated with serious infections and poor prognosis. Compared with ST239, ST59, or other nSMRSA strains, patients infected with SMRSA strains have higher 30-day mortality, increased levels of inflammatory biomarkers, and more frequent ICU hospitalization and invasive procedures. |
| doi_str_mv | 10.1007/s42770-021-00557-5 |
| format | Article |
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Staphylococcus aureus
(MRSA) is an important human pathogen that can cause serious infectious diseases. An emerging MRSA strain, ST5-SCC
mec
II
spa
-type-t2460 (SMRSA), has spread rapidly since its recent emergence in China, but little information is available about this lineage. In this study, 91 MRSA isolates were collected from patients treated in the Zhongnan Hospital, Wuhan University, from 2018 to 2019, and investigated for their molecular characteristics, antibiotic resistance profiles, and clinical characteristics. The predominant lineage, SMRSA, accounted for 37.4% (34/91) of the isolates, followed by ST239-SCC
mec
III-t030 (19.8%, 18/91) and ST59-SCC
mec
IV-t437 (8.8%, 8/91). In contrast to the latter two non-SMRSA (nSMRSA) lineages, which are among the main MRSA found in Chinese settings, SMRSA exhibited small colony variant (SCV) phenotype and had extremely high resistance rates to erythromycin (100.0%), clindamycin (100.0%), levofloxacin (100.0%), tetracycline (97.1%), moxifloxacin (97.1%), and ciprofloxacin (100%), but was more susceptible to rifampicin (resistance rate 3%). The levels of white blood cells (WBC) and procalcitonin (PCT) and the 30-day mortality in patients infected with SMRSA were (12.54 ± 6.61) × 10
9
/L, 0.66 ng/mL, and 52.9%, respectively, which were much higher than those in patients infected with nSMRSA. In addition, patients infected with SMRSA were more frequently admitted to the intensive care unit (ICU) and submitted to invasive procedures than those infected with nSMRSA. In conclusion, SMRSA showed SCV phenotype and exhibited multiple antibiotic-resistance profiles. In this study, SMRSA was associated with serious infections and poor prognosis. Compared with ST239, ST59, or other nSMRSA strains, patients infected with SMRSA strains have higher 30-day mortality, increased levels of inflammatory biomarkers, and more frequent ICU hospitalization and invasive procedures.</description><identifier>ISSN: 1517-8382</identifier><identifier>EISSN: 1678-4405</identifier><identifier>DOI: 10.1007/s42770-021-00557-5</identifier><identifier>PMID: 34235706</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Antimicrobial agents ; Biomarkers ; Biomedical and Life Sciences ; China ; Ciprofloxacin ; Clindamycin ; Clinical Microbiology - Research Paper ; Drug resistance ; Drug Resistance, Bacterial ; Erythromycin ; Food Microbiology ; Genotype ; High resistance ; Hospitals - statistics & numerical data ; Humans ; Infectious diseases ; Inflammation ; Leukocytes ; Levofloxacin ; Life Sciences ; Medical Microbiology ; Methicillin ; Methicillin-Resistant Staphylococcus aureus - genetics ; Microbial Ecology ; Microbial Genetics and Genomics ; Microbial Sensitivity Tests ; Microbiology ; Mortality ; Moxifloxacin ; Mycology ; Patients ; Phenotypes ; Procalcitonin ; Public health ; Rifampin ; Species Specificity ; Staphylococcal Infections - microbiology ; Staphylococcal Infections - mortality ; Staphylococcus aureus ; Staphylococcus infections</subject><ispartof>Brazilian journal of microbiology, 2021-12, Vol.52 (4), p.1929-1936</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-243e7359e8df33da2a70d718e3ca860881c5cf92ac8db3250f225abf8c72eb33</citedby><cites>FETCH-LOGICAL-c474t-243e7359e8df33da2a70d718e3ca860881c5cf92ac8db3250f225abf8c72eb33</cites><orcidid>0000-0002-5619-1614</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578356/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578356/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34235706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xuehan</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Zhang, Yifan</creatorcontrib><creatorcontrib>Zhou, Junying</creatorcontrib><creatorcontrib>Li, Xinwei</creatorcontrib><creatorcontrib>Feng, Ruo</creatorcontrib><creatorcontrib>Li, Yirong</creatorcontrib><title>Methicillin-resistant Staphylococcus aureus of the clonal lineage ST5-SCCmecII-t2460 was associated with high mortality in a Wuhan hospital</title><title>Brazilian journal of microbiology</title><addtitle>Braz J Microbiol</addtitle><addtitle>Braz J Microbiol</addtitle><description>Methicillin-resistant
Staphylococcus aureus
(MRSA) is an important human pathogen that can cause serious infectious diseases. An emerging MRSA strain, ST5-SCC
mec
II
spa
-type-t2460 (SMRSA), has spread rapidly since its recent emergence in China, but little information is available about this lineage. In this study, 91 MRSA isolates were collected from patients treated in the Zhongnan Hospital, Wuhan University, from 2018 to 2019, and investigated for their molecular characteristics, antibiotic resistance profiles, and clinical characteristics. The predominant lineage, SMRSA, accounted for 37.4% (34/91) of the isolates, followed by ST239-SCC
mec
III-t030 (19.8%, 18/91) and ST59-SCC
mec
IV-t437 (8.8%, 8/91). In contrast to the latter two non-SMRSA (nSMRSA) lineages, which are among the main MRSA found in Chinese settings, SMRSA exhibited small colony variant (SCV) phenotype and had extremely high resistance rates to erythromycin (100.0%), clindamycin (100.0%), levofloxacin (100.0%), tetracycline (97.1%), moxifloxacin (97.1%), and ciprofloxacin (100%), but was more susceptible to rifampicin (resistance rate 3%). The levels of white blood cells (WBC) and procalcitonin (PCT) and the 30-day mortality in patients infected with SMRSA were (12.54 ± 6.61) × 10
9
/L, 0.66 ng/mL, and 52.9%, respectively, which were much higher than those in patients infected with nSMRSA. In addition, patients infected with SMRSA were more frequently admitted to the intensive care unit (ICU) and submitted to invasive procedures than those infected with nSMRSA. In conclusion, SMRSA showed SCV phenotype and exhibited multiple antibiotic-resistance profiles. In this study, SMRSA was associated with serious infections and poor prognosis. Compared with ST239, ST59, or other nSMRSA strains, patients infected with SMRSA strains have higher 30-day mortality, increased levels of inflammatory biomarkers, and more frequent ICU hospitalization and invasive procedures.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>China</subject><subject>Ciprofloxacin</subject><subject>Clindamycin</subject><subject>Clinical Microbiology - Research Paper</subject><subject>Drug resistance</subject><subject>Drug Resistance, Bacterial</subject><subject>Erythromycin</subject><subject>Food Microbiology</subject><subject>Genotype</subject><subject>High resistance</subject><subject>Hospitals - statistics & numerical data</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Leukocytes</subject><subject>Levofloxacin</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Methicillin</subject><subject>Methicillin-Resistant Staphylococcus aureus - genetics</subject><subject>Microbial Ecology</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Mortality</subject><subject>Moxifloxacin</subject><subject>Mycology</subject><subject>Patients</subject><subject>Phenotypes</subject><subject>Procalcitonin</subject><subject>Public health</subject><subject>Rifampin</subject><subject>Species Specificity</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal Infections - mortality</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><issn>1517-8382</issn><issn>1678-4405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kcuO1DAQRSMEYoaBH2CBLLFhY3D8iJ0NEmrxaGkQi26JpVXtVDoeJXFjOzPqb-Cn8dDD8FiwKst17i2Xb1U9r9nrmjH9JkmuNaOM15QxpTRVD6rzutGGSsnUw3JWtaZGGH5WPUnpijGumOSPqzMhuVCaNefV98-YB-_8OPqZRkw-ZZgz2WQ4DMcxuODckggsEUsJPckDEjeGGUZSFAh7JJutopvVakK3XtPMZcPIDRRNSsF5yNiRG58HMvj9QKYQM4w-H4mfCZCvywAzGUI6-HL9tHrUw5jw2V29qLYf3m9Xn-jll4_r1btL6qSWmXIpUAvVoul6ITrgoFmna4PCgWmYMbVTrm85ONPtRFm551zBrjdOc9wJcVG9Pdkelt2EncM5RxjtIfoJ4tEG8PbvzuwHuw_X1ihthGqKwas7gxi-LZiynXxyOI4wY1iS5Uq2jWmkYgV9-Q96FZZYfu-WapUybct4ofiJcjGkFLG_f0zN7G3U9hS1LVHbn1FbVUQv_lzjXvIr2wKIE5BKa95j_D37P7Y_AH07tnc</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Li, Xuehan</creator><creator>Zhang, Jing</creator><creator>Zhang, Yifan</creator><creator>Zhou, Junying</creator><creator>Li, Xinwei</creator><creator>Feng, Ruo</creator><creator>Li, Yirong</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5619-1614</orcidid></search><sort><creationdate>20211201</creationdate><title>Methicillin-resistant Staphylococcus aureus of the clonal lineage ST5-SCCmecII-t2460 was associated with high mortality in a Wuhan hospital</title><author>Li, Xuehan ; Zhang, Jing ; Zhang, Yifan ; Zhou, Junying ; Li, Xinwei ; Feng, Ruo ; Li, Yirong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-243e7359e8df33da2a70d718e3ca860881c5cf92ac8db3250f225abf8c72eb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>China</topic><topic>Ciprofloxacin</topic><topic>Clindamycin</topic><topic>Clinical Microbiology - Research Paper</topic><topic>Drug resistance</topic><topic>Drug Resistance, Bacterial</topic><topic>Erythromycin</topic><topic>Food Microbiology</topic><topic>Genotype</topic><topic>High resistance</topic><topic>Hospitals - statistics & numerical data</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Leukocytes</topic><topic>Levofloxacin</topic><topic>Life Sciences</topic><topic>Medical Microbiology</topic><topic>Methicillin</topic><topic>Methicillin-Resistant Staphylococcus aureus - genetics</topic><topic>Microbial Ecology</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Mortality</topic><topic>Moxifloxacin</topic><topic>Mycology</topic><topic>Patients</topic><topic>Phenotypes</topic><topic>Procalcitonin</topic><topic>Public health</topic><topic>Rifampin</topic><topic>Species Specificity</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal Infections - mortality</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xuehan</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Zhang, Yifan</creatorcontrib><creatorcontrib>Zhou, Junying</creatorcontrib><creatorcontrib>Li, Xinwei</creatorcontrib><creatorcontrib>Feng, Ruo</creatorcontrib><creatorcontrib>Li, Yirong</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brazilian journal of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xuehan</au><au>Zhang, Jing</au><au>Zhang, Yifan</au><au>Zhou, Junying</au><au>Li, Xinwei</au><au>Feng, Ruo</au><au>Li, Yirong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methicillin-resistant Staphylococcus aureus of the clonal lineage ST5-SCCmecII-t2460 was associated with high mortality in a Wuhan hospital</atitle><jtitle>Brazilian journal of microbiology</jtitle><stitle>Braz J Microbiol</stitle><addtitle>Braz J Microbiol</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>52</volume><issue>4</issue><spage>1929</spage><epage>1936</epage><pages>1929-1936</pages><issn>1517-8382</issn><eissn>1678-4405</eissn><abstract>Methicillin-resistant
Staphylococcus aureus
(MRSA) is an important human pathogen that can cause serious infectious diseases. An emerging MRSA strain, ST5-SCC
mec
II
spa
-type-t2460 (SMRSA), has spread rapidly since its recent emergence in China, but little information is available about this lineage. In this study, 91 MRSA isolates were collected from patients treated in the Zhongnan Hospital, Wuhan University, from 2018 to 2019, and investigated for their molecular characteristics, antibiotic resistance profiles, and clinical characteristics. The predominant lineage, SMRSA, accounted for 37.4% (34/91) of the isolates, followed by ST239-SCC
mec
III-t030 (19.8%, 18/91) and ST59-SCC
mec
IV-t437 (8.8%, 8/91). In contrast to the latter two non-SMRSA (nSMRSA) lineages, which are among the main MRSA found in Chinese settings, SMRSA exhibited small colony variant (SCV) phenotype and had extremely high resistance rates to erythromycin (100.0%), clindamycin (100.0%), levofloxacin (100.0%), tetracycline (97.1%), moxifloxacin (97.1%), and ciprofloxacin (100%), but was more susceptible to rifampicin (resistance rate 3%). The levels of white blood cells (WBC) and procalcitonin (PCT) and the 30-day mortality in patients infected with SMRSA were (12.54 ± 6.61) × 10
9
/L, 0.66 ng/mL, and 52.9%, respectively, which were much higher than those in patients infected with nSMRSA. In addition, patients infected with SMRSA were more frequently admitted to the intensive care unit (ICU) and submitted to invasive procedures than those infected with nSMRSA. In conclusion, SMRSA showed SCV phenotype and exhibited multiple antibiotic-resistance profiles. In this study, SMRSA was associated with serious infections and poor prognosis. Compared with ST239, ST59, or other nSMRSA strains, patients infected with SMRSA strains have higher 30-day mortality, increased levels of inflammatory biomarkers, and more frequent ICU hospitalization and invasive procedures.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>34235706</pmid><doi>10.1007/s42770-021-00557-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5619-1614</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Brazilian journal of microbiology, 2021-12, Vol.52 (4), p.1929-1936 |
| issn | 1517-8382 1678-4405 |
| language | eng |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Antimicrobial agents Biomarkers Biomedical and Life Sciences China Ciprofloxacin Clindamycin Clinical Microbiology - Research Paper Drug resistance Drug Resistance, Bacterial Erythromycin Food Microbiology Genotype High resistance Hospitals - statistics & numerical data Humans Infectious diseases Inflammation Leukocytes Levofloxacin Life Sciences Medical Microbiology Methicillin Methicillin-Resistant Staphylococcus aureus - genetics Microbial Ecology Microbial Genetics and Genomics Microbial Sensitivity Tests Microbiology Mortality Moxifloxacin Mycology Patients Phenotypes Procalcitonin Public health Rifampin Species Specificity Staphylococcal Infections - microbiology Staphylococcal Infections - mortality Staphylococcus aureus Staphylococcus infections |
| title | Methicillin-resistant Staphylococcus aureus of the clonal lineage ST5-SCCmecII-t2460 was associated with high mortality in a Wuhan hospital |
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