Efficacy of Aidi Injection and Brucea javanica Oil Emulsion Injection in Rectal Cancer during CapeOX Adjuvant Chemotherapy
Background. Adjuvant chemotherapy with CapeOX regimen is widely used in resected rectal cancer, which brings benefits to patients. But drug-related toxicities are severe during this process; thus, survival outcomes may potentially be affected. This study explored the efficacy of two Chinese herbal i...
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| description | Background. Adjuvant chemotherapy with CapeOX regimen is widely used in resected rectal cancer, which brings benefits to patients. But drug-related toxicities are severe during this process; thus, survival outcomes may potentially be affected. This study explored the efficacy of two Chinese herbal injections, Aidi injection (ADI) and Brucea javanica oil emulsion injection (BJOEI), as adjuvant drugs in CapeOX adjuvant chemotherapy on rectal cancer patients. Methods. A total of 240 cases were enrolled in this retrospective study. 80 cases received CapeOX with ADI (the ADI group), 80 cases received CapeOX with BJOEI (the BJOEI group), and the rest 80 cases received CapeOX alone (the control group). After four cycles’ chemotherapy, adverse reactions (ADRs) and quality of life (QOL) were analyzed. Then, patients received follow-up for at least one year, and the endpoint was disease-free survival (DFS). Results. All patients completed at least four cycles’ adjuvant chemotherapy. The incidence of leukopenia and thrombocytopenia was significantly lower in the ADI group; the incidence of nausea was significantly lower in the BJOEI group; the incidence of hand-foot syndrome was significantly lower in both the ADI group and BJOEI group. Significant difference was found in the control group regarding the Karnofsky Performance Status (KPS) scores prior and posttreatment. No difference was found among three groups regarding one-year DFS. Conclusion. As adjuvant drugs for rectal cancer during CapeOX chemotherapy, ADI shows advantages in decreasing leukopenia and thrombocytopenia, while BJOEI results better in remitting nausea. Both two CHIs had positive impacts on decreasing hand-foot syndrome and the maintenance of patients’ QOL. It is worthy of further study and promotion for CHIs. |
| doi_str_mv | 10.1155/2021/2033353 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8577932</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2597343999</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-5bd6a603dfb5f6c1162e7ae10d04d849cc990a32bedb7254ed4ed9f2af73b0a3</originalsourceid><addsrcrecordid>eNp9kc1rFDEYh4NYbKm9eZaAF8FuzedkchHWZauFwoL04C1k8tHNMJOsmZmW9a83665r7cEQkje8Dw95-QHwBqMrjDn_SBDB5aCUcvoCnBGK2azCDL881pSegothaFFZNa6QrF6BU8pExSvBz8DPpffBaLOFycN5sAHexNaZMaQIdbTwc56M07DVDzoWDq5CB5f91A074C8aIvxWSt3BhY7GZWinHOJ9eW3c6juc23YqghEu1q5P49plvdm-Bided4O7ONzn4O56ebf4OrtdfblZzG9nhrF6nPHGVrpC1PqG-8pgXBEntMPIImZrJo2REmlKGmcbQThztmzpifaCNqVxDj7ttZup6Z01Lo5Zd2qTQ6_zViUd1L-dGNbqPj2omgshKSmC9wdBTj8mN4yqD4NxXaejS9OgCJeC1QIjXNB3z9A2TTmW6X5TlFEpZaEu95TJaRiy88fPYKR2sapdrOoQa8HfPh3gCP8JsQAf9sA6RKsfw_91vwBEwasr</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2597343999</pqid></control><display><type>article</type><title>Efficacy of Aidi Injection and Brucea javanica Oil Emulsion Injection in Rectal Cancer during CapeOX Adjuvant Chemotherapy</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Meng, Wenjun ; Zeng, Xiaoge ; Gao, Yuchen ; Chen, Qi ; Bai, Lian</creator><contributor>Shen, Yingbin</contributor><creatorcontrib>Meng, Wenjun ; Zeng, Xiaoge ; Gao, Yuchen ; Chen, Qi ; Bai, Lian ; Shen, Yingbin</creatorcontrib><description>Background. Adjuvant chemotherapy with CapeOX regimen is widely used in resected rectal cancer, which brings benefits to patients. But drug-related toxicities are severe during this process; thus, survival outcomes may potentially be affected. This study explored the efficacy of two Chinese herbal injections, Aidi injection (ADI) and Brucea javanica oil emulsion injection (BJOEI), as adjuvant drugs in CapeOX adjuvant chemotherapy on rectal cancer patients. Methods. A total of 240 cases were enrolled in this retrospective study. 80 cases received CapeOX with ADI (the ADI group), 80 cases received CapeOX with BJOEI (the BJOEI group), and the rest 80 cases received CapeOX alone (the control group). After four cycles’ chemotherapy, adverse reactions (ADRs) and quality of life (QOL) were analyzed. Then, patients received follow-up for at least one year, and the endpoint was disease-free survival (DFS). Results. All patients completed at least four cycles’ adjuvant chemotherapy. The incidence of leukopenia and thrombocytopenia was significantly lower in the ADI group; the incidence of nausea was significantly lower in the BJOEI group; the incidence of hand-foot syndrome was significantly lower in both the ADI group and BJOEI group. Significant difference was found in the control group regarding the Karnofsky Performance Status (KPS) scores prior and posttreatment. No difference was found among three groups regarding one-year DFS. Conclusion. As adjuvant drugs for rectal cancer during CapeOX chemotherapy, ADI shows advantages in decreasing leukopenia and thrombocytopenia, while BJOEI results better in remitting nausea. Both two CHIs had positive impacts on decreasing hand-foot syndrome and the maintenance of patients’ QOL. It is worthy of further study and promotion for CHIs.</description><identifier>ISSN: 2314-6133</identifier><identifier>ISSN: 2314-6141</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/2033353</identifier><identifier>PMID: 34765675</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biomedical research ; Brucea javanica ; Cancer ; Cancer therapies ; Case-Control Studies ; Chemotherapy ; Chemotherapy, Adjuvant - adverse effects ; Chemotherapy, Adjuvant - methods ; China - epidemiology ; Chinese medicine ; Colorectal cancer ; Colorectal Neoplasms - drug therapy ; Disease-Free Survival ; Drug dosages ; Drugs ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - pharmacology ; Emulsions - therapeutic use ; Feet ; Female ; Herbal medicine ; Hospitals ; Humans ; Injection ; Injections - methods ; Laparoscopy ; Leukopenia ; Leukopenia - drug therapy ; Leukopenia - prevention & control ; Male ; Medical prognosis ; Middle Aged ; Nausea ; Nausea - drug therapy ; Nausea - prevention & control ; Patients ; Pharmaceuticals ; Quality of Life ; Rectal Neoplasms - drug therapy ; Rectum ; Retrospective Studies ; Surgery ; Survival ; Thrombocytopenia ; Thrombocytopenia - drug therapy ; Thrombocytopenia - prevention & control ; Toxicity ; Treatment Outcome ; Tumors</subject><ispartof>BioMed research international, 2021, Vol.2021 (1), p.2033353</ispartof><rights>Copyright © 2021 Wenjun Meng et al.</rights><rights>Copyright © 2021 Wenjun Meng et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Wenjun Meng et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-5bd6a603dfb5f6c1162e7ae10d04d849cc990a32bedb7254ed4ed9f2af73b0a3</citedby><cites>FETCH-LOGICAL-c448t-5bd6a603dfb5f6c1162e7ae10d04d849cc990a32bedb7254ed4ed9f2af73b0a3</cites><orcidid>0000-0002-6780-8720 ; 0000-0002-7368-6600</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577932/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577932/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34765675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Shen, Yingbin</contributor><creatorcontrib>Meng, Wenjun</creatorcontrib><creatorcontrib>Zeng, Xiaoge</creatorcontrib><creatorcontrib>Gao, Yuchen</creatorcontrib><creatorcontrib>Chen, Qi</creatorcontrib><creatorcontrib>Bai, Lian</creatorcontrib><title>Efficacy of Aidi Injection and Brucea javanica Oil Emulsion Injection in Rectal Cancer during CapeOX Adjuvant Chemotherapy</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. Adjuvant chemotherapy with CapeOX regimen is widely used in resected rectal cancer, which brings benefits to patients. But drug-related toxicities are severe during this process; thus, survival outcomes may potentially be affected. This study explored the efficacy of two Chinese herbal injections, Aidi injection (ADI) and Brucea javanica oil emulsion injection (BJOEI), as adjuvant drugs in CapeOX adjuvant chemotherapy on rectal cancer patients. Methods. A total of 240 cases were enrolled in this retrospective study. 80 cases received CapeOX with ADI (the ADI group), 80 cases received CapeOX with BJOEI (the BJOEI group), and the rest 80 cases received CapeOX alone (the control group). After four cycles’ chemotherapy, adverse reactions (ADRs) and quality of life (QOL) were analyzed. Then, patients received follow-up for at least one year, and the endpoint was disease-free survival (DFS). Results. All patients completed at least four cycles’ adjuvant chemotherapy. The incidence of leukopenia and thrombocytopenia was significantly lower in the ADI group; the incidence of nausea was significantly lower in the BJOEI group; the incidence of hand-foot syndrome was significantly lower in both the ADI group and BJOEI group. Significant difference was found in the control group regarding the Karnofsky Performance Status (KPS) scores prior and posttreatment. No difference was found among three groups regarding one-year DFS. Conclusion. As adjuvant drugs for rectal cancer during CapeOX chemotherapy, ADI shows advantages in decreasing leukopenia and thrombocytopenia, while BJOEI results better in remitting nausea. Both two CHIs had positive impacts on decreasing hand-foot syndrome and the maintenance of patients’ QOL. It is worthy of further study and promotion for CHIs.</description><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biomedical research</subject><subject>Brucea javanica</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Case-Control Studies</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant - adverse effects</subject><subject>Chemotherapy, Adjuvant - methods</subject><subject>China - epidemiology</subject><subject>Chinese medicine</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Disease-Free Survival</subject><subject>Drug dosages</subject><subject>Drugs</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Emulsions - therapeutic use</subject><subject>Feet</subject><subject>Female</subject><subject>Herbal medicine</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Injection</subject><subject>Injections - methods</subject><subject>Laparoscopy</subject><subject>Leukopenia</subject><subject>Leukopenia - drug therapy</subject><subject>Leukopenia - prevention & control</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Nausea</subject><subject>Nausea - drug therapy</subject><subject>Nausea - prevention & control</subject><subject>Patients</subject><subject>Pharmaceuticals</subject><subject>Quality of Life</subject><subject>Rectal Neoplasms - drug therapy</subject><subject>Rectum</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - drug therapy</subject><subject>Thrombocytopenia - prevention & control</subject><subject>Toxicity</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>2314-6133</issn><issn>2314-6141</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1rFDEYh4NYbKm9eZaAF8FuzedkchHWZauFwoL04C1k8tHNMJOsmZmW9a83665r7cEQkje8Dw95-QHwBqMrjDn_SBDB5aCUcvoCnBGK2azCDL881pSegothaFFZNa6QrF6BU8pExSvBz8DPpffBaLOFycN5sAHexNaZMaQIdbTwc56M07DVDzoWDq5CB5f91A074C8aIvxWSt3BhY7GZWinHOJ9eW3c6juc23YqghEu1q5P49plvdm-Bided4O7ONzn4O56ebf4OrtdfblZzG9nhrF6nPHGVrpC1PqG-8pgXBEntMPIImZrJo2REmlKGmcbQThztmzpifaCNqVxDj7ttZup6Z01Lo5Zd2qTQ6_zViUd1L-dGNbqPj2omgshKSmC9wdBTj8mN4yqD4NxXaejS9OgCJeC1QIjXNB3z9A2TTmW6X5TlFEpZaEu95TJaRiy88fPYKR2sapdrOoQa8HfPh3gCP8JsQAf9sA6RKsfw_91vwBEwasr</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Meng, Wenjun</creator><creator>Zeng, Xiaoge</creator><creator>Gao, Yuchen</creator><creator>Chen, Qi</creator><creator>Bai, Lian</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6780-8720</orcidid><orcidid>https://orcid.org/0000-0002-7368-6600</orcidid></search><sort><creationdate>2021</creationdate><title>Efficacy of Aidi Injection and Brucea javanica Oil Emulsion Injection in Rectal Cancer during CapeOX Adjuvant Chemotherapy</title><author>Meng, Wenjun ; Zeng, Xiaoge ; Gao, Yuchen ; Chen, Qi ; Bai, Lian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-5bd6a603dfb5f6c1162e7ae10d04d849cc990a32bedb7254ed4ed9f2af73b0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biomedical research</topic><topic>Brucea javanica</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Case-Control Studies</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant - adverse effects</topic><topic>Chemotherapy, Adjuvant - methods</topic><topic>China - epidemiology</topic><topic>Chinese medicine</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Disease-Free Survival</topic><topic>Drug dosages</topic><topic>Drugs</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Emulsions - therapeutic use</topic><topic>Feet</topic><topic>Female</topic><topic>Herbal medicine</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Injection</topic><topic>Injections - methods</topic><topic>Laparoscopy</topic><topic>Leukopenia</topic><topic>Leukopenia - drug therapy</topic><topic>Leukopenia - prevention & control</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Nausea</topic><topic>Nausea - drug therapy</topic><topic>Nausea - prevention & control</topic><topic>Patients</topic><topic>Pharmaceuticals</topic><topic>Quality of Life</topic><topic>Rectal Neoplasms - drug therapy</topic><topic>Rectum</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Survival</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - drug therapy</topic><topic>Thrombocytopenia - prevention & control</topic><topic>Toxicity</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meng, Wenjun</creatorcontrib><creatorcontrib>Zeng, Xiaoge</creatorcontrib><creatorcontrib>Gao, Yuchen</creatorcontrib><creatorcontrib>Chen, Qi</creatorcontrib><creatorcontrib>Bai, Lian</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Wenjun</au><au>Zeng, Xiaoge</au><au>Gao, Yuchen</au><au>Chen, Qi</au><au>Bai, Lian</au><au>Shen, Yingbin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Aidi Injection and Brucea javanica Oil Emulsion Injection in Rectal Cancer during CapeOX Adjuvant Chemotherapy</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>1</issue><spage>2033353</spage><pages>2033353-</pages><issn>2314-6133</issn><issn>2314-6141</issn><eissn>2314-6141</eissn><abstract>Background. Adjuvant chemotherapy with CapeOX regimen is widely used in resected rectal cancer, which brings benefits to patients. But drug-related toxicities are severe during this process; thus, survival outcomes may potentially be affected. This study explored the efficacy of two Chinese herbal injections, Aidi injection (ADI) and Brucea javanica oil emulsion injection (BJOEI), as adjuvant drugs in CapeOX adjuvant chemotherapy on rectal cancer patients. Methods. A total of 240 cases were enrolled in this retrospective study. 80 cases received CapeOX with ADI (the ADI group), 80 cases received CapeOX with BJOEI (the BJOEI group), and the rest 80 cases received CapeOX alone (the control group). After four cycles’ chemotherapy, adverse reactions (ADRs) and quality of life (QOL) were analyzed. Then, patients received follow-up for at least one year, and the endpoint was disease-free survival (DFS). Results. All patients completed at least four cycles’ adjuvant chemotherapy. The incidence of leukopenia and thrombocytopenia was significantly lower in the ADI group; the incidence of nausea was significantly lower in the BJOEI group; the incidence of hand-foot syndrome was significantly lower in both the ADI group and BJOEI group. Significant difference was found in the control group regarding the Karnofsky Performance Status (KPS) scores prior and posttreatment. No difference was found among three groups regarding one-year DFS. Conclusion. As adjuvant drugs for rectal cancer during CapeOX chemotherapy, ADI shows advantages in decreasing leukopenia and thrombocytopenia, while BJOEI results better in remitting nausea. Both two CHIs had positive impacts on decreasing hand-foot syndrome and the maintenance of patients’ QOL. It is worthy of further study and promotion for CHIs.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34765675</pmid><doi>10.1155/2021/2033353</doi><orcidid>https://orcid.org/0000-0002-6780-8720</orcidid><orcidid>https://orcid.org/0000-0002-7368-6600</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomedical research Brucea javanica Cancer Cancer therapies Case-Control Studies Chemotherapy Chemotherapy, Adjuvant - adverse effects Chemotherapy, Adjuvant - methods China - epidemiology Chinese medicine Colorectal cancer Colorectal Neoplasms - drug therapy Disease-Free Survival Drug dosages Drugs Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacology Emulsions - therapeutic use Feet Female Herbal medicine Hospitals Humans Injection Injections - methods Laparoscopy Leukopenia Leukopenia - drug therapy Leukopenia - prevention & control Male Medical prognosis Middle Aged Nausea Nausea - drug therapy Nausea - prevention & control Patients Pharmaceuticals Quality of Life Rectal Neoplasms - drug therapy Rectum Retrospective Studies Surgery Survival Thrombocytopenia Thrombocytopenia - drug therapy Thrombocytopenia - prevention & control Toxicity Treatment Outcome Tumors |
| title | Efficacy of Aidi Injection and Brucea javanica Oil Emulsion Injection in Rectal Cancer during CapeOX Adjuvant Chemotherapy |
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