Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Oxygen-Glucose Deprivation/Reperfusion-Induced Microglial Pyroptosis by Promoting FOXO3a-Dependent Mitophagy

Background. Mesenchymal stem cell-derived exosomes (MSC-exos) have been recognized as a promising therapeutic strategy for neonatal hypoxic-ischemic brain damage (HIBD). Recently, microglial pyroptosis was shown to play a vital role in the progression of neonatal HIBD. However, whether MSC-exos impr...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.6219715-6219715
Hauptverfasser:	Hu, Zhenzhen, Yuan, Ya, Zhang, Xiuli, Lu, Yifeng, Dong, Na, Jiang, Xiuqin, Xu, Jinjin, Zheng, Datong
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell culture Exosomes - physiology Forkhead Box Protein O3 - metabolism Glucose Glucose - deficiency Humans Hypoxia Hypoxia - physiopathology Mesenchymal Stem Cells - cytology Microglia - cytology Microglia - metabolism Microglia - pathology Microscopy Mitophagy Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma - prevention & control Particle size Pyroptosis Reperfusion Injury - etiology Reperfusion Injury - pathology Reperfusion Injury - prevention & control Software Stem cells Traumatic brain injury Umbilical cord Umbilical Cord - cytology
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