Infection of Glia by Human Pegivirus Suppresses Peroxisomal and Antiviral Signaling Pathways

Human pegivirus (HPgV) infects peripheral leukocytes but was recently shown to be a neurotropic virus associated with leukoencephalitis in humans. In the present study, we investigated the neural cell tropism of HPgV as well as its effects on host immune responses. HPgV wild type (WT) and a mutant v...

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Veröffentlicht in:	Journal of virology 2021-11, Vol.95 (23), p.e0107421-e0107421
Hauptverfasser:	Doan, M A L, Roczkowsky, A, Smith, M, Blevins, G, van Landeghem, F K H, Gelman, B B, Branton, W G, Stapleton, J T, Hobman, T C, Power, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Astrocytes Brain - metabolism Brain - pathology Flaviviridae Infections - genetics Flaviviridae Infections - metabolism Flaviviridae Infections - virology Gene Expression Humans Microglia - metabolism Microglia - virology Neuroglia - metabolism Neuroglia - pathology Neuroglia - virology Pathogenesis and Immunity Pegivirus - drug effects Pegivirus - genetics Pegivirus - metabolism Phylogeny RNA, Viral - genetics Signal Transduction - drug effects Spotlight Spotlight Selection Viral Nonstructural Proteins - genetics Virology
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