A secure system for genomics clinical decision support
[Display omitted] •A secure remote repository and computation for genomic data is proposed.•A numerical representation of genomic data has been defined.•Homomorphic encryptionenables secure computations for decision support. We developed a prototype genomic archiving and communications system to sec...
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| Veröffentlicht in: | Journal of biomedical informatics 2020-12, Vol.112, p.103602-103602, Article 103602 |
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| container_title | Journal of biomedical informatics |
| container_volume | 112 |
| creator | Karimi, Seemeen Jiang, Xiaoqian Dolin, Robert H. Kim, Miran Boxwala, Aziz |
| description | [Display omitted]
•A secure remote repository and computation for genomic data is proposed.•A numerical representation of genomic data has been defined.•Homomorphic encryptionenables secure computations for decision support.
We developed a prototype genomic archiving and communications system to securely store genome data and provide clinical decision support (CDS). This system operates on a client-server model. The client encrypts the data, and the server stores data and performs the computations necessary for CDS. Computations are directly performed on encrypted data, and the client decrypts results. The server cannot decrypt inputs or outputs, which provides strong guarantees of security. We have validated our system with three genomics-based CDS applications. The results demonstrate that it is possible to resolve a long-standing dilemma in genomic data privacy and accessibility, by using a principled cryptographical framework and a mathematical representation of genome data and CDS questions. |
| doi_str_mv | 10.1016/j.jbi.2020.103602 |
| format | Article |
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•A secure remote repository and computation for genomic data is proposed.•A numerical representation of genomic data has been defined.•Homomorphic encryptionenables secure computations for decision support.
We developed a prototype genomic archiving and communications system to securely store genome data and provide clinical decision support (CDS). This system operates on a client-server model. The client encrypts the data, and the server stores data and performs the computations necessary for CDS. Computations are directly performed on encrypted data, and the client decrypts results. The server cannot decrypt inputs or outputs, which provides strong guarantees of security. We have validated our system with three genomics-based CDS applications. The results demonstrate that it is possible to resolve a long-standing dilemma in genomic data privacy and accessibility, by using a principled cryptographical framework and a mathematical representation of genome data and CDS questions.</description><identifier>ISSN: 1532-0464</identifier><identifier>EISSN: 1532-0480</identifier><identifier>DOI: 10.1016/j.jbi.2020.103602</identifier><identifier>PMID: 33080397</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Genome archiving and communications system ; Genomic computation ; Homomorphic encryption ; Secure clinical decision support ; Secure outsourcing</subject><ispartof>Journal of biomedical informatics, 2020-12, Vol.112, p.103602-103602, Article 103602</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c403t-dbdf488d46d5dfb192eabc7433812193f5f85aaf10e1b67efd519397a38afed93</cites><orcidid>0000-0002-5910-5523 ; 0000-0001-9933-2205</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jbi.2020.103602$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33080397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karimi, Seemeen</creatorcontrib><creatorcontrib>Jiang, Xiaoqian</creatorcontrib><creatorcontrib>Dolin, Robert H.</creatorcontrib><creatorcontrib>Kim, Miran</creatorcontrib><creatorcontrib>Boxwala, Aziz</creatorcontrib><title>A secure system for genomics clinical decision support</title><title>Journal of biomedical informatics</title><addtitle>J Biomed Inform</addtitle><description>[Display omitted]
•A secure remote repository and computation for genomic data is proposed.•A numerical representation of genomic data has been defined.•Homomorphic encryptionenables secure computations for decision support.
We developed a prototype genomic archiving and communications system to securely store genome data and provide clinical decision support (CDS). This system operates on a client-server model. The client encrypts the data, and the server stores data and performs the computations necessary for CDS. Computations are directly performed on encrypted data, and the client decrypts results. The server cannot decrypt inputs or outputs, which provides strong guarantees of security. We have validated our system with three genomics-based CDS applications. The results demonstrate that it is possible to resolve a long-standing dilemma in genomic data privacy and accessibility, by using a principled cryptographical framework and a mathematical representation of genome data and CDS questions.</description><subject>Genome archiving and communications system</subject><subject>Genomic computation</subject><subject>Homomorphic encryption</subject><subject>Secure clinical decision support</subject><subject>Secure outsourcing</subject><issn>1532-0464</issn><issn>1532-0480</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhoMoXkYfwI106WbGXJomRRBk8AYDbnQd0uRkzNA2Y9IK8_Z26DjoxtW5_ec_hw-hS4JnBJPiZjVbVX5GMd3WrMD0AJ0SzugU5xIf7vMiP0FnKa0wJoTz4hidMIYlZqU4RcV9lsD0EbK0SR00mQsxW0IbGm9SZmrfeqPrzILxyYc2S_16HWJ3jo6crhNc7OIEvT8-vM2fp4vXp5f5_WJqcsy6qa2sy6W0eWG5dRUpKejKiJwxSSgpmeNOcq0dwUCqQoCzfOiWQjOpHdiSTdDd6LvuqwasgbaLulbr6BsdNypor_5OWv-hluFLSS4EFWIwuN4ZxPDZQ-pU45OButYthD4pmnNaColzOkjJKDUxpBTB7c8QrLa81UoNvNWWtxp5DztXv__bb_wAHgS3owAGSl8eokrGQ2vA-gimUzb4f-y_AYr-kX4</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Karimi, Seemeen</creator><creator>Jiang, Xiaoqian</creator><creator>Dolin, Robert H.</creator><creator>Kim, Miran</creator><creator>Boxwala, Aziz</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5910-5523</orcidid><orcidid>https://orcid.org/0000-0001-9933-2205</orcidid></search><sort><creationdate>20201201</creationdate><title>A secure system for genomics clinical decision support</title><author>Karimi, Seemeen ; Jiang, Xiaoqian ; Dolin, Robert H. ; Kim, Miran ; Boxwala, Aziz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-dbdf488d46d5dfb192eabc7433812193f5f85aaf10e1b67efd519397a38afed93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Genome archiving and communications system</topic><topic>Genomic computation</topic><topic>Homomorphic encryption</topic><topic>Secure clinical decision support</topic><topic>Secure outsourcing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karimi, Seemeen</creatorcontrib><creatorcontrib>Jiang, Xiaoqian</creatorcontrib><creatorcontrib>Dolin, Robert H.</creatorcontrib><creatorcontrib>Kim, Miran</creatorcontrib><creatorcontrib>Boxwala, Aziz</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomedical informatics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karimi, Seemeen</au><au>Jiang, Xiaoqian</au><au>Dolin, Robert H.</au><au>Kim, Miran</au><au>Boxwala, Aziz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A secure system for genomics clinical decision support</atitle><jtitle>Journal of biomedical informatics</jtitle><addtitle>J Biomed Inform</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>112</volume><spage>103602</spage><epage>103602</epage><pages>103602-103602</pages><artnum>103602</artnum><issn>1532-0464</issn><eissn>1532-0480</eissn><abstract>[Display omitted]
•A secure remote repository and computation for genomic data is proposed.•A numerical representation of genomic data has been defined.•Homomorphic encryptionenables secure computations for decision support.
We developed a prototype genomic archiving and communications system to securely store genome data and provide clinical decision support (CDS). This system operates on a client-server model. The client encrypts the data, and the server stores data and performs the computations necessary for CDS. Computations are directly performed on encrypted data, and the client decrypts results. The server cannot decrypt inputs or outputs, which provides strong guarantees of security. We have validated our system with three genomics-based CDS applications. The results demonstrate that it is possible to resolve a long-standing dilemma in genomic data privacy and accessibility, by using a principled cryptographical framework and a mathematical representation of genome data and CDS questions.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33080397</pmid><doi>10.1016/j.jbi.2020.103602</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5910-5523</orcidid><orcidid>https://orcid.org/0000-0001-9933-2205</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1532-0464 1532-0480 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Genome archiving and communications system Genomic computation Homomorphic encryption Secure clinical decision support Secure outsourcing |
| title | A secure system for genomics clinical decision support |
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