Gremlin 1 — small protein, big impact: the multiorgan consequences of disrupted BMP antagonism

Highly conserved, complex and interacting morphogen signalling pathways regulate adult stem cells and control cell fate determination across numerous different organs. In homeostasis, the bone morphogenetic protein (BMP) pathway predominantly promotes cell differentiation. Localised expression of li...

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Veröffentlicht in:	The Journal of pathology 2020-08, Vol.251 (4), p.349-352
Hauptverfasser:	Gooding, Sarah, Leedham, Simon J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow bone morphogenetic protein Bone Morphogenetic Proteins Cell Differentiation Cell fate Cell self-renewal Cre recombinase Gremlin 1 Gremlin protein haematopoiesis Hematopoietic stem cells Homeostasis Intestine Invited Mice Proteins Signal Transduction Stem Cell Niche Stem cell transplantation Stem cells
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