Efficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma

Background There is no effective therapy for patients with malignant pleural mesothelioma (MPM) who progressed to platinum-based chemotherapy and immunotherapy. Methods We aimed to investigate the antitumor activity of CDK4/6 inhibitors using in vitro and in vivo preclinical models of MPM. Results B...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2021-11, Vol.125 (10), p.1365-1376
Hauptverfasser:	Aliagas, Elisabet, Alay, Ania, Martínez-Iniesta, Maria, Hernández-Madrigal, Miguel, Cordero, David, Gausachs, Mireia, Pros, Eva, Saigí, Maria, Busacca, Sara, Sharkley, Annabel J., Dawson, Alan, Palmero, Ramón, Ruffinelli, José C., Padrones, Susana, Aso, Samantha, Escobar, Ignacio, Ramos, Ricard, Llatjós, Roger, Vidal, August, Dorca, Eduard, Varela, Mar, Sánchez-Céspedes, Montse, Fennell, Dean, Muñoz-Pinedo, Cristina, Villanueva, Alberto, Solé, Xavi, Nadal, Ernest
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4017 692/4028/67/1641 Aged Aminopyridines - administration & dosage Aminopyridines - pharmacology Animals Antigen presentation Antitumor activity Benzimidazoles - administration & dosage Benzimidazoles - pharmacology Biomedical and Life Sciences Biomedicine Cancer Research Cell culture Cell cycle Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy Cyclin-dependent kinase 4 Cyclin-Dependent Kinase 4 - genetics Cyclin-Dependent Kinase 4 - metabolism Cyclin-Dependent Kinase 6 - genetics Cyclin-Dependent Kinase 6 - metabolism Drug Resistance Epidemiology Female Gene Expression Regulation, Neoplastic - drug effects Humans Immunotherapy Interferon Male Mesothelioma Mesothelioma, Malignant - drug therapy Mesothelioma, Malignant - genetics Mesothelioma, Malignant - metabolism Mice Molecular Medicine Oncology Patients Piperazines - administration & dosage Piperazines - pharmacology Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - pharmacology Pyridines - administration & dosage Pyridines - pharmacology Senescence Signal transduction Transcriptomics Tumors Up-Regulation - drug effects Xenograft Model Antitumor Assays Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!