Apalutamide radio-sensitisation of prostate cancer

Introduction The combination of radiotherapy with bicalutamide is the standard treatment of prostate cancer patients with high-risk or locally advanced disease. Whether new-generation anti-androgens, like apalutamide, can improve the radio-curability of these patients is an emerging challenge. Mater...

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Veröffentlicht in:	British journal of cancer 2021-11, Vol.125 (10), p.1377-1387
Hauptverfasser:	Kakouratos, Christos, Kalamida, Dimitra, Lamprou, Ioannis, Xanthopoulou, Erasmia, Nanos, Christos, Giatromanolaki, Alexandra, Koukourakis, Michael I.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/485 692/4028/67/1059/485 Androgens Anilides - administration & dosage Anilides - pharmacology Animals Apoptosis Biomedical and Life Sciences Biomedicine Cancer Research Cell death Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemoradiotherapy DNA damage DNA repair Dose-Response Relationship, Radiation Double-strand break repair Drug Resistance Epidemiology Experiments Humans Male Mice Molecular Medicine Nitriles - administration & dosage Nitriles - pharmacology Oncology Patients PC-3 Cells Prostate cancer Prostatic Neoplasms - therapy Radiation therapy Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - pharmacology S phase Thiohydantoins - administration & dosage Thiohydantoins - pharmacology Tosyl Compounds - administration & dosage Tosyl Compounds - pharmacology Tumor cell lines Xenograft Model Antitumor Assays Xenografts
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