Targeting PINK1 Using Natural Products for the Treatment of Human Diseases

PINK1, also known as PARK6, is a PTEN-induced putative kinase 1 that is encoded by nuclear genes. PINK1 is ubiquitously expressed and regulates mitochondrial function and mitophagy in a range of cell types. The dysregulation of PINK1 is associated with the pathogenesis and development of mitochondri...

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Veröffentlicht in:	BioMed research international 2021, Vol.2021 (1), p.4045819-4045819
Hauptverfasser:	Li, Yan-Qin, Zhang, Fan, Yu, Li-Ping, Mu, Jian-Kang, Yang, Ya-Qin, Yu, Jie, Yang, Xing-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Animals Apoptosis Autophagy Autophagy (Cytology) Biological Products - metabolism Biological Products - pharmacology Biomedical research Cardiovascular diseases Care and treatment Coronary artery disease Cytoplasm Diagnosis Disease DNA damage Drug Therapy - methods Health services Heart diseases Hepatitis Humans Kinases Liver cancer Liver diseases Localization Metabolism Mitochondria Mitochondria - metabolism Mitochondrial diseases Mitochondrial Diseases - drug therapy Mitophagy Movement disorders Musculoskeletal system Mutation Natural products Neurodegenerative diseases NMR Nuclear magnetic resonance Oxidative stress Parkinson's disease Pathogenesis Physiology Protein kinases Protein Kinases - drug effects Protein Kinases - genetics Protein Kinases - metabolism Protein Kinases - physiology Proteins PTEN protein PTEN-induced putative kinase Quality control Review Risk factors Structure-function relationships Tumorigenesis Ubiquitin-Protein Ligases - metabolism
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