Technical standardization of ICG near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy for duplex kidney in pediatric patients
Purpose This study aimed to standardize the operative technique of indocyanine green (ICG) near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy (LPN) and compare it with the standard technique. Methods In the last 4 years, we performed 22 LPN (14 right-sided, 8 left-sided) in children...
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| Veröffentlicht in: | World journal of urology 2021-11, Vol.39 (11), p.4167-4173 |
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| creator | Esposito, Ciro Autorino, Giuseppe Coppola, Vincenzo Esposito, Giorgia Paternoster, Mariano Castagnetti, Marco Cardone, Roberto Cerulo, Mariapina Borgogni, Rachele Cortese, Giuseppe Escolino, Maria |
| description | Purpose
This study aimed to standardize the operative technique of indocyanine green (ICG) near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy (LPN) and compare it with the standard technique.
Methods
In the last 4 years, we performed 22 LPN (14 right-sided, 8 left-sided) in children with non-functioning moiety of duplex kidney. Patients included 12 girls and 10 boys with a median age of 3.9 years (range 1–10). Patients were grouped according to the use of ICG-NIRF: G1 included 12 patients operated using ICG-NIRF and G2 included 10 patients receiving the standard technique. We standardized the technique of injection of ICG in three different steps.
Results
The median operative time was significantly lower in G1 [87 min (range 68–110)] compared with G2 [140 min (range 70–220)] (
p
= 0.001). One intra-operative complication occurred in G2. At post-operative ultrasound (US), the residual moiety was normal in all patients. An asymptomatic renal cyst related to the site of surgery was visualized at US in 8/22 (36%), with a significantly higher incidence in G2 (6/10, 60%) compared with G1 (2/12, 16.6%) (
p
= 0.001). Renogram demonstrated no loss of function of residual moiety. No allergic reactions to ICG occurred.
Conclusion
ICG-NIRF LPN is technically easier, quicker, and safer compared with the standard technique. The main advantages of using ICG-NIRF during LPN are the clear identification of normal ureter, vasculature of non-functioning pole, and demarcation line between the avascular and the perfused pole. The main limitation of ICG technology remains the need for specific laparoscopic equipment that is not always available. |
| doi_str_mv | 10.1007/s00345-021-03759-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8571229</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2593747553</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-185e75925b657fbd17aaa8590a27242e191d1f2fcc0184248306e9e534dffbf13</originalsourceid><addsrcrecordid>eNp9kctuFDEQRVuIiAyBH2CBLLEJiyZ-trs3SGhEwkhRIqGwtjx2OePQYze2GzH8Aj-NkwnhsWBVlurULd-6TfOC4DcEY3mSMWZctJiSFjMphrZ71CwIZ6ztJe0eNwssKW_50LPD5mnONxgT2WHxpDlknNAey2HR_LgCswne6BHlooPVyfrvuvgYUHRotTxDAXRqfXBJJ7DIjXNMkA0EA-j4YvXx9DUa9aRTzCZO3qD6LL6qBZg2CUyJ2x1yMSE7TyN8Q5-9DbBDPqAJrNcl3Y0UD6HkZ82B02OG5_f1qPl0-v5q-aE9vzxbLd-dt4ZLXlrSC6huqVh3Qrq1JVJr3YsBa1r9UiADscRRZwwmPae8Z7iDAQTj1rm1I-yoebvXneb1Fmz1UpIe1ZT8VqeditqrvzvBb9R1_Kp6IQmlQxU4vhdI8csMuaitrycZRx0gzllRwQmjWPZdRV_9g97EOYVqr1IDk1wKwSpF95Spd8wJ3MNnCFa3Wat91qpmre6yVrfSL_-08TDyK9wKsD2QaytcQ_q9-z-yPwFVr7dY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2593747553</pqid></control><display><type>article</type><title>Technical standardization of ICG near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy for duplex kidney in pediatric patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Esposito, Ciro ; Autorino, Giuseppe ; Coppola, Vincenzo ; Esposito, Giorgia ; Paternoster, Mariano ; Castagnetti, Marco ; Cardone, Roberto ; Cerulo, Mariapina ; Borgogni, Rachele ; Cortese, Giuseppe ; Escolino, Maria</creator><creatorcontrib>Esposito, Ciro ; Autorino, Giuseppe ; Coppola, Vincenzo ; Esposito, Giorgia ; Paternoster, Mariano ; Castagnetti, Marco ; Cardone, Roberto ; Cerulo, Mariapina ; Borgogni, Rachele ; Cortese, Giuseppe ; Escolino, Maria</creatorcontrib><description>Purpose
This study aimed to standardize the operative technique of indocyanine green (ICG) near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy (LPN) and compare it with the standard technique.
Methods
In the last 4 years, we performed 22 LPN (14 right-sided, 8 left-sided) in children with non-functioning moiety of duplex kidney. Patients included 12 girls and 10 boys with a median age of 3.9 years (range 1–10). Patients were grouped according to the use of ICG-NIRF: G1 included 12 patients operated using ICG-NIRF and G2 included 10 patients receiving the standard technique. We standardized the technique of injection of ICG in three different steps.
Results
The median operative time was significantly lower in G1 [87 min (range 68–110)] compared with G2 [140 min (range 70–220)] (
p
= 0.001). One intra-operative complication occurred in G2. At post-operative ultrasound (US), the residual moiety was normal in all patients. An asymptomatic renal cyst related to the site of surgery was visualized at US in 8/22 (36%), with a significantly higher incidence in G2 (6/10, 60%) compared with G1 (2/12, 16.6%) (
p
= 0.001). Renogram demonstrated no loss of function of residual moiety. No allergic reactions to ICG occurred.
Conclusion
ICG-NIRF LPN is technically easier, quicker, and safer compared with the standard technique. The main advantages of using ICG-NIRF during LPN are the clear identification of normal ureter, vasculature of non-functioning pole, and demarcation line between the avascular and the perfused pole. The main limitation of ICG technology remains the need for specific laparoscopic equipment that is not always available.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-021-03759-6</identifier><identifier>PMID: 34128079</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Child ; Child, Preschool ; Female ; Humans ; Hypersensitivity ; I.R. radiation ; Indocyanine Green ; Infant ; Kidney - abnormalities ; Kidney - surgery ; Kidneys ; Laparoscopy ; Laparoscopy - methods ; Male ; Medicine ; Medicine & Public Health ; Nephrectomy ; Nephrectomy - methods ; Nephrology ; Oncology ; Optical Imaging - standards ; Original ; Original Article ; Patients ; Pediatrics ; Standardization ; Surgery, Computer-Assisted ; Ureter ; Urology</subject><ispartof>World journal of urology, 2021-11, Vol.39 (11), p.4167-4173</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-185e75925b657fbd17aaa8590a27242e191d1f2fcc0184248306e9e534dffbf13</citedby><cites>FETCH-LOGICAL-c474t-185e75925b657fbd17aaa8590a27242e191d1f2fcc0184248306e9e534dffbf13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-021-03759-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-021-03759-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34128079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Esposito, Ciro</creatorcontrib><creatorcontrib>Autorino, Giuseppe</creatorcontrib><creatorcontrib>Coppola, Vincenzo</creatorcontrib><creatorcontrib>Esposito, Giorgia</creatorcontrib><creatorcontrib>Paternoster, Mariano</creatorcontrib><creatorcontrib>Castagnetti, Marco</creatorcontrib><creatorcontrib>Cardone, Roberto</creatorcontrib><creatorcontrib>Cerulo, Mariapina</creatorcontrib><creatorcontrib>Borgogni, Rachele</creatorcontrib><creatorcontrib>Cortese, Giuseppe</creatorcontrib><creatorcontrib>Escolino, Maria</creatorcontrib><title>Technical standardization of ICG near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy for duplex kidney in pediatric patients</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Purpose
This study aimed to standardize the operative technique of indocyanine green (ICG) near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy (LPN) and compare it with the standard technique.
Methods
In the last 4 years, we performed 22 LPN (14 right-sided, 8 left-sided) in children with non-functioning moiety of duplex kidney. Patients included 12 girls and 10 boys with a median age of 3.9 years (range 1–10). Patients were grouped according to the use of ICG-NIRF: G1 included 12 patients operated using ICG-NIRF and G2 included 10 patients receiving the standard technique. We standardized the technique of injection of ICG in three different steps.
Results
The median operative time was significantly lower in G1 [87 min (range 68–110)] compared with G2 [140 min (range 70–220)] (
p
= 0.001). One intra-operative complication occurred in G2. At post-operative ultrasound (US), the residual moiety was normal in all patients. An asymptomatic renal cyst related to the site of surgery was visualized at US in 8/22 (36%), with a significantly higher incidence in G2 (6/10, 60%) compared with G1 (2/12, 16.6%) (
p
= 0.001). Renogram demonstrated no loss of function of residual moiety. No allergic reactions to ICG occurred.
Conclusion
ICG-NIRF LPN is technically easier, quicker, and safer compared with the standard technique. The main advantages of using ICG-NIRF during LPN are the clear identification of normal ureter, vasculature of non-functioning pole, and demarcation line between the avascular and the perfused pole. The main limitation of ICG technology remains the need for specific laparoscopic equipment that is not always available.</description><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>I.R. radiation</subject><subject>Indocyanine Green</subject><subject>Infant</subject><subject>Kidney - abnormalities</subject><subject>Kidney - surgery</subject><subject>Kidneys</subject><subject>Laparoscopy</subject><subject>Laparoscopy - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrectomy</subject><subject>Nephrectomy - methods</subject><subject>Nephrology</subject><subject>Oncology</subject><subject>Optical Imaging - standards</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Standardization</subject><subject>Surgery, Computer-Assisted</subject><subject>Ureter</subject><subject>Urology</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctuFDEQRVuIiAyBH2CBLLEJiyZ-trs3SGhEwkhRIqGwtjx2OePQYze2GzH8Aj-NkwnhsWBVlurULd-6TfOC4DcEY3mSMWZctJiSFjMphrZ71CwIZ6ztJe0eNwssKW_50LPD5mnONxgT2WHxpDlknNAey2HR_LgCswne6BHlooPVyfrvuvgYUHRotTxDAXRqfXBJJ7DIjXNMkA0EA-j4YvXx9DUa9aRTzCZO3qD6LL6qBZg2CUyJ2x1yMSE7TyN8Q5-9DbBDPqAJrNcl3Y0UD6HkZ82B02OG5_f1qPl0-v5q-aE9vzxbLd-dt4ZLXlrSC6huqVh3Qrq1JVJr3YsBa1r9UiADscRRZwwmPae8Z7iDAQTj1rm1I-yoebvXneb1Fmz1UpIe1ZT8VqeditqrvzvBb9R1_Kp6IQmlQxU4vhdI8csMuaitrycZRx0gzllRwQmjWPZdRV_9g97EOYVqr1IDk1wKwSpF95Spd8wJ3MNnCFa3Wat91qpmre6yVrfSL_-08TDyK9wKsD2QaytcQ_q9-z-yPwFVr7dY</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Esposito, Ciro</creator><creator>Autorino, Giuseppe</creator><creator>Coppola, Vincenzo</creator><creator>Esposito, Giorgia</creator><creator>Paternoster, Mariano</creator><creator>Castagnetti, Marco</creator><creator>Cardone, Roberto</creator><creator>Cerulo, Mariapina</creator><creator>Borgogni, Rachele</creator><creator>Cortese, Giuseppe</creator><creator>Escolino, Maria</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211101</creationdate><title>Technical standardization of ICG near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy for duplex kidney in pediatric patients</title><author>Esposito, Ciro ; Autorino, Giuseppe ; Coppola, Vincenzo ; Esposito, Giorgia ; Paternoster, Mariano ; Castagnetti, Marco ; Cardone, Roberto ; Cerulo, Mariapina ; Borgogni, Rachele ; Cortese, Giuseppe ; Escolino, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-185e75925b657fbd17aaa8590a27242e191d1f2fcc0184248306e9e534dffbf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>I.R. radiation</topic><topic>Indocyanine Green</topic><topic>Infant</topic><topic>Kidney - abnormalities</topic><topic>Kidney - surgery</topic><topic>Kidneys</topic><topic>Laparoscopy</topic><topic>Laparoscopy - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrectomy</topic><topic>Nephrectomy - methods</topic><topic>Nephrology</topic><topic>Oncology</topic><topic>Optical Imaging - standards</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Standardization</topic><topic>Surgery, Computer-Assisted</topic><topic>Ureter</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Esposito, Ciro</creatorcontrib><creatorcontrib>Autorino, Giuseppe</creatorcontrib><creatorcontrib>Coppola, Vincenzo</creatorcontrib><creatorcontrib>Esposito, Giorgia</creatorcontrib><creatorcontrib>Paternoster, Mariano</creatorcontrib><creatorcontrib>Castagnetti, Marco</creatorcontrib><creatorcontrib>Cardone, Roberto</creatorcontrib><creatorcontrib>Cerulo, Mariapina</creatorcontrib><creatorcontrib>Borgogni, Rachele</creatorcontrib><creatorcontrib>Cortese, Giuseppe</creatorcontrib><creatorcontrib>Escolino, Maria</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Esposito, Ciro</au><au>Autorino, Giuseppe</au><au>Coppola, Vincenzo</au><au>Esposito, Giorgia</au><au>Paternoster, Mariano</au><au>Castagnetti, Marco</au><au>Cardone, Roberto</au><au>Cerulo, Mariapina</au><au>Borgogni, Rachele</au><au>Cortese, Giuseppe</au><au>Escolino, Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Technical standardization of ICG near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy for duplex kidney in pediatric patients</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>39</volume><issue>11</issue><spage>4167</spage><epage>4173</epage><pages>4167-4173</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Purpose
This study aimed to standardize the operative technique of indocyanine green (ICG) near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy (LPN) and compare it with the standard technique.
Methods
In the last 4 years, we performed 22 LPN (14 right-sided, 8 left-sided) in children with non-functioning moiety of duplex kidney. Patients included 12 girls and 10 boys with a median age of 3.9 years (range 1–10). Patients were grouped according to the use of ICG-NIRF: G1 included 12 patients operated using ICG-NIRF and G2 included 10 patients receiving the standard technique. We standardized the technique of injection of ICG in three different steps.
Results
The median operative time was significantly lower in G1 [87 min (range 68–110)] compared with G2 [140 min (range 70–220)] (
p
= 0.001). One intra-operative complication occurred in G2. At post-operative ultrasound (US), the residual moiety was normal in all patients. An asymptomatic renal cyst related to the site of surgery was visualized at US in 8/22 (36%), with a significantly higher incidence in G2 (6/10, 60%) compared with G1 (2/12, 16.6%) (
p
= 0.001). Renogram demonstrated no loss of function of residual moiety. No allergic reactions to ICG occurred.
Conclusion
ICG-NIRF LPN is technically easier, quicker, and safer compared with the standard technique. The main advantages of using ICG-NIRF during LPN are the clear identification of normal ureter, vasculature of non-functioning pole, and demarcation line between the avascular and the perfused pole. The main limitation of ICG technology remains the need for specific laparoscopic equipment that is not always available.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34128079</pmid><doi>10.1007/s00345-021-03759-6</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Child Child, Preschool Female Humans Hypersensitivity I.R. radiation Indocyanine Green Infant Kidney - abnormalities Kidney - surgery Kidneys Laparoscopy Laparoscopy - methods Male Medicine Medicine & Public Health Nephrectomy Nephrectomy - methods Nephrology Oncology Optical Imaging - standards Original Original Article Patients Pediatrics Standardization Surgery, Computer-Assisted Ureter Urology |
| title | Technical standardization of ICG near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy for duplex kidney in pediatric patients |
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