Endogenous µ‐opioid receptor activity in the lateral and capsular subdivisions of the right central nucleus of the amygdala prevents chronic postoperative pain

Tissue injury induces a long‐lasting latent sensitization (LS) of spinal nociceptive signaling that is kept in remission by an opposing µ‐opioid receptor (MOR) constitutive activity. To test the hypothesis that supraspinal sites become engaged, we induced hindpaw inflammation, waited 3 weeks for mec...

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Veröffentlicht in:	Journal of neuroscience research 2022-01, Vol.100 (1), p.48-65
Hauptverfasser:	Cooper, Andrew H., Hedden, Naomi S., Corder, Gregory, Lamerand, Sydney R., Donahue, Renee R., Morales‐Medina, Julio C., Selan, Lindsay, Prasoon, Pranav, Taylor, Bradley K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Animals Aversion Central Amygdaloid Nucleus - metabolism Cerebral ventricles dependence Drug dependence Drug withdrawal Female Hyperalgesia Hyperalgesia - drug therapy Hyperalgesia - metabolism Hyperalgesia - prevention & control Hypersensitivity inflammation Injection Injury prevention Kinases Male Males Mice Microinjection Naloxone Naloxone - pharmacology Naltrexone Narcotic Antagonists - pharmacology Narcotics Opioid receptors Pain Pain perception Pain, Postoperative - drug therapy Pain, Postoperative - prevention & control Postoperative period Protein kinase C Receptors Receptors, Opioid Receptors, Opioid, mu Remission Rodents RRID:AB_10557109 RRID:AB_143157 RRID:AB_2535804 RRID:AB_397780 RRID:IMSR_JAX:007914 Subdivisions Test animals Transgenic mice Ventricles (cerebral) withdrawal
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