PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis

The interferon (IFN) pathway is critical for cytotoxic T cell activation, which is central to tumor immunosurveillance and successful immunotherapy. We demonstrate here that PKCλ/ι inactivation results in the hyper-stimulation of the IFN cascade and the enhanced recruitment of CD8+ T cells that impa...

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Veröffentlicht in:	Molecular cell 2021-11, Vol.81 (21), p.4509-4526.e10
Hauptverfasser:	Linares, Juan F., Zhang, Xiao, Martinez-Ordoñez, Anxo, Duran, Angeles, Kinoshita, Hiroto, Kasashima, Hiroaki, Nakanishi, Naoko, Nakanishi, Yuki, Carelli, Ryan, Cappelli, Luca, Arias, Esperanza, Yashiro, Masakazu, Ohira, Masaichi, Patel, Sanjay, Inghirami, Giorgio, Loda, Massimo, Cuervo, Ana Maria, Diaz-Meco, Maria T., Moscat, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals atypical PKC Autophagy Carcinogenesis CD8-Positive T-Lymphocytes - metabolism Cell Transformation, Neoplastic chaperone-mediated autophagy colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Cycloheximide - chemistry Female HEK293 Cells Humans Immunophenotyping immunosuppression immunosurveillance immunotherapy interferon Interferon Regulatory Factor-3 - metabolism Interferons - metabolism Isoenzymes - metabolism Male Membrane Proteins - metabolism Mice Middle Aged Neoplasm Transplantation Phosphorylation Prognosis Protein Kinase C - metabolism Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Protein Serine-Threonine Kinases - physiology Signal Transduction STING Transcription Factors ULK1/2 Up-Regulation
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