ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non-Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts

M6620, a selective ATP-competitive inhibitor of the ATM and RAD3-related (ATR) kinase, is currently under investigation with radiation in patients with non-small cell lung cancer (NSCLC) brain metastases. We evaluated the DNA damage response (DDR) pathway profile of NSCLC and assessed the radiosensi...

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Veröffentlicht in:	Molecular cancer therapeutics 2021-11, Vol.20 (11), p.2129-2139
Hauptverfasser:	Baschnagel, Andrew M, Elnaggar, Jacob H, VanBeek, Haley J, Kromke, Ashley C, Skiba, Justin H, Kaushik, Saakshi, Abel, Lindsey, Clark, Paul A, Longhurst, Colin A, Nickel, Kwangok P, Leal, Ticiana A, Zhao, Shuang G, Kimple, Randall J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy Female Heterografts Humans Isoxazoles - pharmacology Isoxazoles - therapeutic use Lung Neoplasms - drug therapy Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Mice Mice, Nude Neoplasm Metastasis Pyrazines - pharmacology Pyrazines - therapeutic use Treatment Outcome
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