M1 Bone Marrow-Derived Macrophage-Derived Extracellular Vesicles Inhibit Angiogenesis and Myocardial Regeneration Following Myocardial Infarction via the MALAT1/MicroRNA-25-3p/CDC42 Axis

Myocardial infarction (MI) is a severe cardiovascular disease. Some M1 macrophage-derived extracellular vesicles (EVs) are involved in the inhibition of angiogenesis and acceleration dysfunction during MI. However, the potential mechanism of M1 phenotype bone marrow-derived macrophages- (BMMs-) EVs...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.9959746-9959746
Hauptverfasser:	Chen, Bairong, Luo, Liyun, Wei, Xiaoliang, Gong, Dong, Li, Zhihui, Li, Songbiao, Tang, Wenyi, Jin, Lizi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Bone marrow Cardiac function Cardiovascular disease cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Electrocardiography Experiments Extracellular vesicles Extracellular Vesicles - chemistry Female Flow cytometry Heart attacks Laboratory animals Macrophages - cytology Macrophages - metabolism Male Mice Mice, Inbred C57BL MicroRNAs - genetics Mortality Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Ostomy RNA, Long Noncoding - genetics
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