Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis

Senescent cells (SNCs) degenerate the fibrous cap that normally prevents atherogenic plaque rupture, a leading cause of myocardial infarction and stroke. Here we explored the underlying mechanism using pharmacological or transgenic approaches to clear SNCs in the mouse model of atherosclerosis. SNC...

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Veröffentlicht in:	Nature aging 2021-08, Vol.1 (8), p.698-714
Hauptverfasser:	Childs, Bennett G, Zhang, Cheng, Shuja, Fahad, Sturmlechner, Ines, Trewartha, Shawn, Fierro Velasco, Raul, Baker, Darren, Li, Hu, van Deursen, Jan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis Atherosclerosis - drug therapy Cellular Senescence Insulin-like growth factors Mice Myocardial Infarction - metabolism Myocytes, Smooth Muscle - metabolism Plaque, Atherosclerotic - genetics Smooth muscle
Online-Zugang:	Volltext
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