8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules

Solution chemical properties of two novel 8-hydroxyquinoline-D-proline and homo-proline hybrids were investigated along with their complex formation with [Rh(η -C Me )(H O) ] and [Ru(η - -cymene)(H O) ] ions by pH-potentiometry, UV-visible spectrophotometry and H NMR spectroscopy. Due to the zwitter...

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Veröffentlicht in:	International journal of molecular sciences 2021-10, Vol.22 (20), p.11281
Hauptverfasser:	Pivarcsik, Tamás, Dömötör, Orsolya, Mészáros, János P, May, Nóra V, Spengler, Gabriella, Csuvik, Oszkár, Szatmári, István, Enyedy, Éva A
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxyquinoline Adenocarcinoma Amino acids Amino Acids - chemistry Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Biomolecules Cancer Capillary electrophoresis Cell Proliferation Circular dichroism Colon Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Complex formation Coordination Complexes - chemistry Coordination Complexes - pharmacology Crystallography Cytotoxicity Deoxyribonucleic acid Dichroism DNA Electrical measurement Electrophoresis Fluorimetry Fluorometry Human serum albumin Humans Hybrids Hydrogen bonds Hydroxyquinoline Ligands Magnetic resonance spectroscopy Multidrug resistance Multidrug resistant organisms Nitrogen NMR NMR spectroscopy Nuclear magnetic resonance Oxyquinoline - chemistry p-Cymene Potentiometric analysis Proline Rhodium - chemistry Ruthenium Ruthenium - chemistry Selectivity Serum albumin Spectrophotometry Tumor cell lines Tumor Cells, Cultured
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