Discovery and Validation of an Epithelial-Mesenchymal Transition-Based Signature in Gastric Cancer by Genomics and Prognosis Analysis

Objective. Epithelial-mesenchymal transition (EMT) exerts a key function in cancer initiation and progression. Herein, we aimed to develop an EMT-based prognostic signature in gastric cancer. Methods. The gene expression profiles of gastric cancer were obtained from TCGA dataset as a training set an...

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Veröffentlicht in:	BioMed research international 2021, Vol.2021 (1), p.9026918-9026918
Hauptverfasser:	Xu, Huiyong, Wan, Huilai, Zhu, Maoshu, Feng, Lianghua, Zhang, Hui, Su, Fengbing
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Biomarkers, Tumor - genetics Cancer Cancer therapies Care and treatment CD4 antigen CD8 antigen Cell transformation Chemotherapy Computational Biology - methods Databases, Genetic Datasets Development and progression Diagnosis Dkk1 protein Epithelial-Mesenchymal Transition Extracellular matrix Extracellular Matrix Proteins - genetics Gastric cancer Gene Expression Genetic aspects Genomes Genomics Genomics - methods Glycoproteins - genetics Health aspects Humans Intercellular Signaling Peptides and Proteins - genetics Lymphocytes Lymphocytes T Macrophages Matrilin Proteins - genetics Medical prognosis Mesenchyme Microenvironments Patients Plasminogen Activator Inhibitor 1 - genetics Prognosis Regression analysis Reproducibility of Results Risk analysis Risk Factors ROC Curve Software Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Transcriptome - genetics Tumor Microenvironment - genetics Wnt protein
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