Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

The issue of treating sickle cell disease with drugs that increase hemoglobin oxygen affinity has come to the fore with the US Food and Drug Administration approval in 2019 of voxelotor, the only antisickling drug approved since hydroxyurea in 1998. Voxelotor reduces sickling by increasing the conce...

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Veröffentlicht in:	Blood 2021-09, Vol.138 (13), p.1172-1181
Hauptverfasser:	Henry, Eric R., Metaferia, Belhu, Li, Quan, Harper, Julia, Best, Robert B., Glass, Kristen E., Cellmer, Troy, Dunkelberger, Emily B., Conrey, Anna, Thein, Swee Lay, Bunn, H. Franklin, Eaton, William A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Red Cells, Iron, and Erythropoiesis
Online-Zugang:	Volltext
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