MEFV mutation frequencies in a Turkish cohort with low prevalence of familial Mediterranean fever
Familial Mediterranean fever (FMF) is a genetically recessive autoinflammatory disease caused by mutations in the Mediterranean fever (MEFV) gene. The aim of this study was to investigate the frequencies of the most common MEFV mutations among a sample of healthy individuals from the Havsa populatio...
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Veröffentlicht in: | TURKISH JOURNAL OF MEDICAL SCIENCES 2021-08, Vol.51 (4), p.1702-1705 |
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description | Familial Mediterranean fever (FMF) is a genetically recessive autoinflammatory disease caused by mutations in the Mediterranean fever (MEFV) gene. The aim of this study was to investigate the frequencies of the most common MEFV mutations among a sample of healthy individuals from the Havsa population of European Turkey, where FMF is less prevalent compared to Asian Turkey.
The study group consisted of 263 unrelated healthy adults. All of the participants were analyzed for the M694V, V726A, M680I, and E148Q mutations in the MEFV gene.
In total, 25 of the 263 individuals carried MEFV mutations (9.5%). The observed allele frequencies were 1.5% for M694V (95% confidence interval [CI] 0.5-2.5), 2.6% for E148Q (95% CI 1.6-3.9), 0.5% for M680I (95% CI 0.0-1.1), and 0.0% for V726A. The frequencies of the M694V, M680I, and E148Q mutations were not significantly different from allele frequencies (approximately 20%) determined for other regions of Turkey where FMF is more prevalent.
These data suggest that the positivity of the MEFV gene mutation tests have lower predictive value in a population with low FMF prevalence. |
doi_str_mv | 10.3906/sag-2009-119 |
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The study group consisted of 263 unrelated healthy adults. All of the participants were analyzed for the M694V, V726A, M680I, and E148Q mutations in the MEFV gene.
In total, 25 of the 263 individuals carried MEFV mutations (9.5%). The observed allele frequencies were 1.5% for M694V (95% confidence interval [CI] 0.5-2.5), 2.6% for E148Q (95% CI 1.6-3.9), 0.5% for M680I (95% CI 0.0-1.1), and 0.0% for V726A. The frequencies of the M694V, M680I, and E148Q mutations were not significantly different from allele frequencies (approximately 20%) determined for other regions of Turkey where FMF is more prevalent.
These data suggest that the positivity of the MEFV gene mutation tests have lower predictive value in a population with low FMF prevalence.</description><identifier>ISSN: 1303-6165</identifier><identifier>ISSN: 1300-0144</identifier><identifier>EISSN: 1303-6165</identifier><identifier>DOI: 10.3906/sag-2009-119</identifier><identifier>PMID: 33315354</identifier><language>eng</language><publisher>Turkey: The Scientific and Technological Research Council of Turkey</publisher><subject>Adult ; Familial Mediterranean Fever - ethnology ; Familial Mediterranean Fever - genetics ; Gene Frequency ; Healthy Volunteers ; Humans ; Middle Aged ; Mutation - genetics ; Mutation Rate ; Predictive Value of Tests ; Prevalence ; Pyrin - genetics ; Turkey - epidemiology</subject><ispartof>TURKISH JOURNAL OF MEDICAL SCIENCES, 2021-08, Vol.51 (4), p.1702-1705</ispartof><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><rights>Copyright © 2021 The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-ca1f2767867efc365fddd24d9a58e5c6cf3b2deee0f90ca2f8349a28f1c680e23</citedby><orcidid>0000-0002-9815-8177 ; 0000-0001-6073-0724 ; 0000-0002-0060-2859 ; 0000-0002-8833-697X ; 0000-0001-6175-0647</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569729/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569729/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33315354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çakır, Necati</creatorcontrib><creatorcontrib>Azaklı, Hülya</creatorcontrib><creatorcontrib>Üstek, Duran</creatorcontrib><creatorcontrib>Uysal, Ömer</creatorcontrib><creatorcontrib>Gözke, Eren</creatorcontrib><title>MEFV mutation frequencies in a Turkish cohort with low prevalence of familial Mediterranean fever</title><title>TURKISH JOURNAL OF MEDICAL SCIENCES</title><addtitle>Turk J Med Sci</addtitle><description>Familial Mediterranean fever (FMF) is a genetically recessive autoinflammatory disease caused by mutations in the Mediterranean fever (MEFV) gene. The aim of this study was to investigate the frequencies of the most common MEFV mutations among a sample of healthy individuals from the Havsa population of European Turkey, where FMF is less prevalent compared to Asian Turkey.
The study group consisted of 263 unrelated healthy adults. All of the participants were analyzed for the M694V, V726A, M680I, and E148Q mutations in the MEFV gene.
In total, 25 of the 263 individuals carried MEFV mutations (9.5%). The observed allele frequencies were 1.5% for M694V (95% confidence interval [CI] 0.5-2.5), 2.6% for E148Q (95% CI 1.6-3.9), 0.5% for M680I (95% CI 0.0-1.1), and 0.0% for V726A. The frequencies of the M694V, M680I, and E148Q mutations were not significantly different from allele frequencies (approximately 20%) determined for other regions of Turkey where FMF is more prevalent.
These data suggest that the positivity of the MEFV gene mutation tests have lower predictive value in a population with low FMF prevalence.</description><subject>Adult</subject><subject>Familial Mediterranean Fever - ethnology</subject><subject>Familial Mediterranean Fever - genetics</subject><subject>Gene Frequency</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Mutation - genetics</subject><subject>Mutation Rate</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Pyrin - genetics</subject><subject>Turkey - epidemiology</subject><issn>1303-6165</issn><issn>1300-0144</issn><issn>1303-6165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1PwkAQhjdGI4jePJv9AVb3o126FxNDQE0gXtDrZtjO0tXS4raF-O8tQQmeZpJ532eSh5Brzu6kZuq-hmUkGNMR5_qE9LlkMlJcJadHe49c1PUHY0LGiT4nPSklT2QS9wnMxpN3umobaHxVUhfwq8XSeqypLynQeRs-fZ1TW-VVaOjWNzktqi1dB9xA0SWRVo46WPnCQ0FnmPkGQ4ASoaPhBsMlOXNQ1Hj1OwfkbTKej56j6evTy-hxGlmZxk1kgTsxVMNUDdFZqRKXZZmIMw1JiolV1smFyBCROc0sCJfKWINIHbcqZSjkgDzsuet2scLMYtkEKMw6-BWEb1OBN_8vpc_NstqYNFF6KHQHuN0DbKjqOqA7dDkzO9WmU212qk2nuovfHP87hP_cyh_h-H2l</recordid><startdate>20210830</startdate><enddate>20210830</enddate><creator>Çakır, Necati</creator><creator>Azaklı, Hülya</creator><creator>Üstek, Duran</creator><creator>Uysal, Ömer</creator><creator>Gözke, Eren</creator><general>The Scientific and Technological Research Council of Turkey</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9815-8177</orcidid><orcidid>https://orcid.org/0000-0001-6073-0724</orcidid><orcidid>https://orcid.org/0000-0002-0060-2859</orcidid><orcidid>https://orcid.org/0000-0002-8833-697X</orcidid><orcidid>https://orcid.org/0000-0001-6175-0647</orcidid></search><sort><creationdate>20210830</creationdate><title>MEFV mutation frequencies in a Turkish cohort with low prevalence of familial Mediterranean fever</title><author>Çakır, Necati ; Azaklı, Hülya ; Üstek, Duran ; Uysal, Ömer ; Gözke, Eren</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-ca1f2767867efc365fddd24d9a58e5c6cf3b2deee0f90ca2f8349a28f1c680e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Familial Mediterranean Fever - ethnology</topic><topic>Familial Mediterranean Fever - genetics</topic><topic>Gene Frequency</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Mutation - genetics</topic><topic>Mutation Rate</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Pyrin - genetics</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Çakır, Necati</creatorcontrib><creatorcontrib>Azaklı, Hülya</creatorcontrib><creatorcontrib>Üstek, Duran</creatorcontrib><creatorcontrib>Uysal, Ömer</creatorcontrib><creatorcontrib>Gözke, Eren</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>TURKISH JOURNAL OF MEDICAL SCIENCES</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Çakır, Necati</au><au>Azaklı, Hülya</au><au>Üstek, Duran</au><au>Uysal, Ömer</au><au>Gözke, Eren</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MEFV mutation frequencies in a Turkish cohort with low prevalence of familial Mediterranean fever</atitle><jtitle>TURKISH JOURNAL OF MEDICAL SCIENCES</jtitle><addtitle>Turk J Med Sci</addtitle><date>2021-08-30</date><risdate>2021</risdate><volume>51</volume><issue>4</issue><spage>1702</spage><epage>1705</epage><pages>1702-1705</pages><issn>1303-6165</issn><issn>1300-0144</issn><eissn>1303-6165</eissn><abstract>Familial Mediterranean fever (FMF) is a genetically recessive autoinflammatory disease caused by mutations in the Mediterranean fever (MEFV) gene. The aim of this study was to investigate the frequencies of the most common MEFV mutations among a sample of healthy individuals from the Havsa population of European Turkey, where FMF is less prevalent compared to Asian Turkey.
The study group consisted of 263 unrelated healthy adults. All of the participants were analyzed for the M694V, V726A, M680I, and E148Q mutations in the MEFV gene.
In total, 25 of the 263 individuals carried MEFV mutations (9.5%). The observed allele frequencies were 1.5% for M694V (95% confidence interval [CI] 0.5-2.5), 2.6% for E148Q (95% CI 1.6-3.9), 0.5% for M680I (95% CI 0.0-1.1), and 0.0% for V726A. The frequencies of the M694V, M680I, and E148Q mutations were not significantly different from allele frequencies (approximately 20%) determined for other regions of Turkey where FMF is more prevalent.
These data suggest that the positivity of the MEFV gene mutation tests have lower predictive value in a population with low FMF prevalence.</abstract><cop>Turkey</cop><pub>The Scientific and Technological Research Council of Turkey</pub><pmid>33315354</pmid><doi>10.3906/sag-2009-119</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-9815-8177</orcidid><orcidid>https://orcid.org/0000-0001-6073-0724</orcidid><orcidid>https://orcid.org/0000-0002-0060-2859</orcidid><orcidid>https://orcid.org/0000-0002-8833-697X</orcidid><orcidid>https://orcid.org/0000-0001-6175-0647</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adult Familial Mediterranean Fever - ethnology Familial Mediterranean Fever - genetics Gene Frequency Healthy Volunteers Humans Middle Aged Mutation - genetics Mutation Rate Predictive Value of Tests Prevalence Pyrin - genetics Turkey - epidemiology |
title | MEFV mutation frequencies in a Turkish cohort with low prevalence of familial Mediterranean fever |
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